Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exp...
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ftubarcepubl:oai:diposit.ub.edu:2445/117485 2024-02-11T10:04:18+01:00 Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine Rosenquist, Aske Hess Hoyer, Birgit Bjerre Julvez, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jonsson, Bo A. G. Bonde, Jens Peter Toft, Gunnar 2017-10-03 8 p. application/pdf http://hdl.handle.net/2445/117485 eng eng National Institute of Environmental Health Science Reproducció del document publicat a: http://dx.doi.org/10.1289/EHP553 Environmental Health Perspectives, 2017, vol. 125, num. 10, p. 107002 Articles publicats en revistes (ISGlobal) http://dx.doi.org/10.1289/EHP553 info:eu-repo/grantAgreement/EC/FP7/226217/EU//CLEAR 0091-6765 http://hdl.handle.net/2445/117485 28974479 CC0 (c) Rosenquist et al., 2017 http://creativecommons.org/publicdomain/zero/1.0/ info:eu-repo/semantics/openAccess Higiene ambiental Medicina prenatal Grenlàndia Ucraïna Environmental health Prenatal medicine Greenland Ukraine info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2017 ftubarcepubl https://doi.org/10.1289/EHP553 2024-01-24T01:02:46Z BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p'-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and ... Article in Journal/Newspaper Greenland inuit Dipòsit Digital de la Universitat de Barcelona Greenland Environmental Health Perspectives 125 10 107002 |
institution |
Open Polar |
collection |
Dipòsit Digital de la Universitat de Barcelona |
op_collection_id |
ftubarcepubl |
language |
English |
topic |
Higiene ambiental Medicina prenatal Grenlàndia Ucraïna Environmental health Prenatal medicine Greenland Ukraine |
spellingShingle |
Higiene ambiental Medicina prenatal Grenlàndia Ucraïna Environmental health Prenatal medicine Greenland Ukraine Rosenquist, Aske Hess Hoyer, Birgit Bjerre Julvez, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jonsson, Bo A. G. Bonde, Jens Peter Toft, Gunnar Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
topic_facet |
Higiene ambiental Medicina prenatal Grenlàndia Ucraïna Environmental health Prenatal medicine Greenland Ukraine |
description |
BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n=1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for pre- and postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal p,p'-DDE, respectively. CONCLUSION: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and ... |
format |
Article in Journal/Newspaper |
author |
Rosenquist, Aske Hess Hoyer, Birgit Bjerre Julvez, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jonsson, Bo A. G. Bonde, Jens Peter Toft, Gunnar |
author_facet |
Rosenquist, Aske Hess Hoyer, Birgit Bjerre Julvez, Jordi Sunyer Deu, Jordi Pedersen, Henning Sloth Lenters, Virissa Jonsson, Bo A. G. Bonde, Jens Peter Toft, Gunnar |
author_sort |
Rosenquist, Aske Hess |
title |
Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
title_short |
Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
title_full |
Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
title_fullStr |
Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
title_full_unstemmed |
Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine |
title_sort |
prenatal and postnatal pcb-153 and p,p'-dde exposures and behavior scores at 5-9 years of age among children in greenland and ukraine |
publisher |
National Institute of Environmental Health Science |
publishDate |
2017 |
url |
http://hdl.handle.net/2445/117485 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_relation |
Reproducció del document publicat a: http://dx.doi.org/10.1289/EHP553 Environmental Health Perspectives, 2017, vol. 125, num. 10, p. 107002 Articles publicats en revistes (ISGlobal) http://dx.doi.org/10.1289/EHP553 info:eu-repo/grantAgreement/EC/FP7/226217/EU//CLEAR 0091-6765 http://hdl.handle.net/2445/117485 28974479 |
op_rights |
CC0 (c) Rosenquist et al., 2017 http://creativecommons.org/publicdomain/zero/1.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1289/EHP553 |
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Environmental Health Perspectives |
container_volume |
125 |
container_issue |
10 |
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107002 |
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1790600871699021824 |