Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación
The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular matrix helps cells to bind together and regulates several cellular functions such as adhesio...
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Universitat de Barcelona
2014
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ftubarcelona:oai:www.tdx.cat:10803/133023 2023-12-24T10:25:27+01:00 Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación Torres Núñez, Eva Rotllant Moragas, Josep Planas Vilarnau, Josep Universitat de Barcelona. Departament de Fisiologia i Immunologia 2014-02-21 application/pdf 278 p. http://hdl.handle.net/10803/133023 eng eng Universitat de Barcelona B 10143-2014 http://hdl.handle.net/10803/133023 L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess TDX (Tesis Doctorals en Xarxa) Proteïnes Proteínas Proteins Matriu extracel·lular Matriz extracelular Extracellular matrix Hematopoesi Hematopoyesis Hematopoiesis Metilació Metilación Methylation Rèmol de petxines Rodaballos Turbot Osteonectina Osteonectin Ciències Experimentals i Matemàtiques 59 info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion 2014 ftubarcelona 2023-11-30T06:33:41Z The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular matrix helps cells to bind together and regulates several cellular functions such as adhesion, migration, proliferation and differentiation. It is composed of growth factors, proteoglycans, structural proteins and matricellular proteins. Osteonectin, also named Sparc (Secreted Protein Acidic and Rich in Cysteine) or BM-40 (Membrane Protein-40), is a multifunctional glycoprotein that belongs to the matricellular protein family. This group modulates matrix-cellular interactions and takes part in several cell functions, rather than playing a role in the cell structure. Sparc is known to have high affinity with calcium ions and was first discovered as the major component of ECM in mineral tissues, although it has since been located in many other tissues. Sparc expression is high during early development but remains low in adult life. However, it is expressed in tissues under renewal, tissue repair or tumorigenesis. Since Sparc is able to interact with multiple molecules, many important functions have been attributed to this protein, including counteradhesion, the regulation of cell proliferation and angiogenic activity. Analysis of the results obtained during this PhD Thesis leads to the following conclusions: • Sparc is as an important regulator of embryonic haematopoiesis during early development in zebrafish. Specifically, it mediates erythroid progenitor cell development regulating gata1 and βe3globin expression. • Similar defects in blood phenotypes of sparc and fgfs knockdowns and the capacity to partially rescue the fgf21 blood phenotype places sparc downstream of fgf21 signaling genetic network. • UV exposure induces an increase in the p53 and sparc expression • According with the conclusion 3, a possible molecular mechanism induced by sparc after UV-radiation is suggested to be the responsible in part ... Doctoral or Postdoctoral Thesis Turbot Universitat de Barcelona: Theses and Dissertations Online (TDX) |
institution |
Open Polar |
collection |
Universitat de Barcelona: Theses and Dissertations Online (TDX) |
op_collection_id |
ftubarcelona |
language |
English |
topic |
Proteïnes Proteínas Proteins Matriu extracel·lular Matriz extracelular Extracellular matrix Hematopoesi Hematopoyesis Hematopoiesis Metilació Metilación Methylation Rèmol de petxines Rodaballos Turbot Osteonectina Osteonectin Ciències Experimentals i Matemàtiques 59 |
spellingShingle |
Proteïnes Proteínas Proteins Matriu extracel·lular Matriz extracelular Extracellular matrix Hematopoesi Hematopoyesis Hematopoiesis Metilació Metilación Methylation Rèmol de petxines Rodaballos Turbot Osteonectina Osteonectin Ciències Experimentals i Matemàtiques 59 Torres Núñez, Eva Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
topic_facet |
Proteïnes Proteínas Proteins Matriu extracel·lular Matriz extracelular Extracellular matrix Hematopoesi Hematopoyesis Hematopoiesis Metilació Metilación Methylation Rèmol de petxines Rodaballos Turbot Osteonectina Osteonectin Ciències Experimentals i Matemàtiques 59 |
description |
The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular matrix helps cells to bind together and regulates several cellular functions such as adhesion, migration, proliferation and differentiation. It is composed of growth factors, proteoglycans, structural proteins and matricellular proteins. Osteonectin, also named Sparc (Secreted Protein Acidic and Rich in Cysteine) or BM-40 (Membrane Protein-40), is a multifunctional glycoprotein that belongs to the matricellular protein family. This group modulates matrix-cellular interactions and takes part in several cell functions, rather than playing a role in the cell structure. Sparc is known to have high affinity with calcium ions and was first discovered as the major component of ECM in mineral tissues, although it has since been located in many other tissues. Sparc expression is high during early development but remains low in adult life. However, it is expressed in tissues under renewal, tissue repair or tumorigenesis. Since Sparc is able to interact with multiple molecules, many important functions have been attributed to this protein, including counteradhesion, the regulation of cell proliferation and angiogenic activity. Analysis of the results obtained during this PhD Thesis leads to the following conclusions: • Sparc is as an important regulator of embryonic haematopoiesis during early development in zebrafish. Specifically, it mediates erythroid progenitor cell development regulating gata1 and βe3globin expression. • Similar defects in blood phenotypes of sparc and fgfs knockdowns and the capacity to partially rescue the fgf21 blood phenotype places sparc downstream of fgf21 signaling genetic network. • UV exposure induces an increase in the p53 and sparc expression • According with the conclusion 3, a possible molecular mechanism induced by sparc after UV-radiation is suggested to be the responsible in part ... |
author2 |
Rotllant Moragas, Josep Planas Vilarnau, Josep Universitat de Barcelona. Departament de Fisiologia i Immunologia |
format |
Doctoral or Postdoctoral Thesis |
author |
Torres Núñez, Eva |
author_facet |
Torres Núñez, Eva |
author_sort |
Torres Núñez, Eva |
title |
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
title_short |
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
title_full |
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
title_fullStr |
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
title_full_unstemmed |
Sparc (Osteonectin): new insight into the function and regulation = Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación |
title_sort |
sparc (osteonectin): new insight into the function and regulation = sparc (osteonectin): nuevos conocimientos sobre sus funciones y regulación |
publisher |
Universitat de Barcelona |
publishDate |
2014 |
url |
http://hdl.handle.net/10803/133023 |
genre |
Turbot |
genre_facet |
Turbot |
op_source |
TDX (Tesis Doctorals en Xarxa) |
op_relation |
B 10143-2014 http://hdl.handle.net/10803/133023 |
op_rights |
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
_version_ |
1786201248814333952 |