​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
Tomàs Marquès-Bonet forma part del Zoonomia Consortium We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and...
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ftuabarcelonapb:oai:ddd.uab.cat:286973 2024-04-21T08:03:43+00:00 ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs Moon, Katherine L. Huson, Heather J. Morrill, Kathleen Wang, Ming-Shan Li, Xue Srikanth, Krishnamoorthy Lindblad-Toh, Kerstin Svenson, Gavin J. Karlsson, Elinor K. Shapiro, Beth 2023 application/pdf https://ddd.uab.cat/record/286973 eng eng European Commission 864203 Science Vol. 380 Num. 6643 (April 2023), art. eabn5887 https://ddd.uab.cat/record/286973 urn:10.1126/science.abn5887 urn:oai:ddd.uab.cat:286973 urn:pmid:37104591 urn:pmc-uid:10184777 urn:pmcid:PMC10184777 urn:oai:pubmedcentral.nih.gov:10184777 urn:articleid:10959203v380n6643eabn5887 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Article 2023 ftuabarcelonapb 2024-03-26T09:32:10Z Tomà s Marquès-Bonet forma part del Zoonomia Consortium We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enhanced starch digestion compared with Greenland sled dogs and a compendium of derived homozygous coding variants at constrained positions in genes connected to bone and skin development. We propose that Balto's population of origin, which was less inbred and genetically healthier than modern breeds, was adapted to the extreme environment of 1920s Alaska. Article in Journal/Newspaper Greenland Nome Alaska Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
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Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
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ftuabarcelonapb |
language |
English |
description |
Tomàs Marquès-Bonet forma part del Zoonomia Consortium We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enhanced starch digestion compared with Greenland sled dogs and a compendium of derived homozygous coding variants at constrained positions in genes connected to bone and skin development. We propose that Balto's population of origin, which was less inbred and genetically healthier than modern breeds, was adapted to the extreme environment of 1920s Alaska. |
format |
Article in Journal/Newspaper |
author |
Moon, Katherine L. Huson, Heather J. Morrill, Kathleen Wang, Ming-Shan Li, Xue Srikanth, Krishnamoorthy Lindblad-Toh, Kerstin Svenson, Gavin J. Karlsson, Elinor K. Shapiro, Beth |
spellingShingle |
Moon, Katherine L. Huson, Heather J. Morrill, Kathleen Wang, Ming-Shan Li, Xue Srikanth, Krishnamoorthy Lindblad-Toh, Kerstin Svenson, Gavin J. Karlsson, Elinor K. Shapiro, Beth ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
author_facet |
Moon, Katherine L. Huson, Heather J. Morrill, Kathleen Wang, Ming-Shan Li, Xue Srikanth, Krishnamoorthy Lindblad-Toh, Kerstin Svenson, Gavin J. Karlsson, Elinor K. Shapiro, Beth |
author_sort |
Moon, Katherine L. |
title |
​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
title_short |
​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
title_full |
​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
title_fullStr |
​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
title_full_unstemmed |
​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
title_sort |
​comparative genomics of balto, a famous historic dog, captures lost diversity of 1920s sled dogs |
publishDate |
2023 |
url |
https://ddd.uab.cat/record/286973 |
genre |
Greenland Nome Alaska |
genre_facet |
Greenland Nome Alaska |
op_relation |
European Commission 864203 Science Vol. 380 Num. 6643 (April 2023), art. eabn5887 https://ddd.uab.cat/record/286973 urn:10.1126/science.abn5887 urn:oai:ddd.uab.cat:286973 urn:pmid:37104591 urn:pmc-uid:10184777 urn:pmcid:PMC10184777 urn:oai:pubmedcentral.nih.gov:10184777 urn:articleid:10959203v380n6643eabn5887 |
op_rights |
open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ |
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1796943456612909056 |