West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020)
West Nile virus lineage 2 (WNV-L2) emerged in Europe in 2004; since then, it has spread across the continent, causing outbreaks in humans and animals. During 2017 and 2020, WNV-L2 was detected and isolated from four northern goshawks in two provinces of Catalonia (north-eastern Spain). In order to c...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2022
|
Subjects: | |
Online Access: | https://ddd.uab.cat/record/258168 |
id |
ftuabarcelonapb:oai:ddd.uab.cat:258168 |
---|---|
record_format |
openpolar |
spelling |
ftuabarcelonapb:oai:ddd.uab.cat:258168 2023-11-12T04:23:17+01:00 West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) Aguilera-Sepúlveda, Pilar Napp Avelli, Sebastián Llorente, Francisco Solano-Manrique, Carlos Molina-López, Rafael Obón, Elena Solé, Alba Jiménez-Clavero, Miguel Ángel Fernández-Pinero, Jovita Busquets, Núria 2022 application/pdf https://ddd.uab.cat/record/258168 eng eng Viruses Vol. 14 (march 2022) https://ddd.uab.cat/record/258168 urn:10.3390/v14030569 urn:oai:ddd.uab.cat:258168 urn:pmcid:PMC8951896 urn:pmc-uid:8951896 urn:pmid:35336976 urn:oai:pubmedcentral.nih.gov:8951896 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ West Nile virus Lineage-2 Spain Phylogeny Avian host Northern goshawk Overwintering Europe Article 2022 ftuabarcelonapb 2023-10-17T23:52:18Z West Nile virus lineage 2 (WNV-L2) emerged in Europe in 2004; since then, it has spread across the continent, causing outbreaks in humans and animals. During 2017 and 2020, WNV-L2 was detected and isolated from four northern goshawks in two provinces of Catalonia (north-eastern Spain). In order to characterise the first Spanish WNV-L2 isolates and elucidate the potential overwintering of the virus in this Mediterranean region, complete genome sequencing, phylogenetic analyses, and a study of phenotypic characterisation were performed. Our results showed that these Spanish isolates belonged to the central-southern WNV-L2 clade. In more detail, they were related to the Lombardy cluster that emerged in Italy in 2013 and has been able to spread westwards, causing outbreaks in France (2018) and Spain (2017 and 2020). Phenotypic characterisation performed in vitro showed that these isolates presented characteristics corresponding to strains of moderate to high virulence. All these findings evidence that these WNV-L2 strains have been able to circulate and overwinter in the region, and are pathogenic, at least in northern goshawks, which seem to be very susceptible to WNV infection and may be good indicators of WNV-L2 circulation. Due to the increasing number of human and animal cases in Europe in the last years, this zoonotic flavivirus should be kept under extensive surveillance, following a One-Health approach. Article in Journal/Newspaper Northern Goshawk Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
institution |
Open Polar |
collection |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
op_collection_id |
ftuabarcelonapb |
language |
English |
topic |
West Nile virus Lineage-2 Spain Phylogeny Avian host Northern goshawk Overwintering Europe |
spellingShingle |
West Nile virus Lineage-2 Spain Phylogeny Avian host Northern goshawk Overwintering Europe Aguilera-Sepúlveda, Pilar Napp Avelli, Sebastián Llorente, Francisco Solano-Manrique, Carlos Molina-López, Rafael Obón, Elena Solé, Alba Jiménez-Clavero, Miguel Ángel Fernández-Pinero, Jovita Busquets, Núria West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
topic_facet |
West Nile virus Lineage-2 Spain Phylogeny Avian host Northern goshawk Overwintering Europe |
description |
West Nile virus lineage 2 (WNV-L2) emerged in Europe in 2004; since then, it has spread across the continent, causing outbreaks in humans and animals. During 2017 and 2020, WNV-L2 was detected and isolated from four northern goshawks in two provinces of Catalonia (north-eastern Spain). In order to characterise the first Spanish WNV-L2 isolates and elucidate the potential overwintering of the virus in this Mediterranean region, complete genome sequencing, phylogenetic analyses, and a study of phenotypic characterisation were performed. Our results showed that these Spanish isolates belonged to the central-southern WNV-L2 clade. In more detail, they were related to the Lombardy cluster that emerged in Italy in 2013 and has been able to spread westwards, causing outbreaks in France (2018) and Spain (2017 and 2020). Phenotypic characterisation performed in vitro showed that these isolates presented characteristics corresponding to strains of moderate to high virulence. All these findings evidence that these WNV-L2 strains have been able to circulate and overwinter in the region, and are pathogenic, at least in northern goshawks, which seem to be very susceptible to WNV infection and may be good indicators of WNV-L2 circulation. Due to the increasing number of human and animal cases in Europe in the last years, this zoonotic flavivirus should be kept under extensive surveillance, following a One-Health approach. |
format |
Article in Journal/Newspaper |
author |
Aguilera-Sepúlveda, Pilar Napp Avelli, Sebastián Llorente, Francisco Solano-Manrique, Carlos Molina-López, Rafael Obón, Elena Solé, Alba Jiménez-Clavero, Miguel Ángel Fernández-Pinero, Jovita Busquets, Núria |
author_facet |
Aguilera-Sepúlveda, Pilar Napp Avelli, Sebastián Llorente, Francisco Solano-Manrique, Carlos Molina-López, Rafael Obón, Elena Solé, Alba Jiménez-Clavero, Miguel Ángel Fernández-Pinero, Jovita Busquets, Núria |
author_sort |
Aguilera-Sepúlveda, Pilar |
title |
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
title_short |
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
title_full |
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
title_fullStr |
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
title_full_unstemmed |
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020) |
title_sort |
west nile virus lineage 2 spreads westwards in europe and overwinters in north-eastern spain (2017-2020) |
publishDate |
2022 |
url |
https://ddd.uab.cat/record/258168 |
genre |
Northern Goshawk |
genre_facet |
Northern Goshawk |
op_relation |
Viruses Vol. 14 (march 2022) https://ddd.uab.cat/record/258168 urn:10.3390/v14030569 urn:oai:ddd.uab.cat:258168 urn:pmcid:PMC8951896 urn:pmc-uid:8951896 urn:pmid:35336976 urn:oai:pubmedcentral.nih.gov:8951896 |
op_rights |
open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1782338105842335744 |