Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology
Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become a...
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ftuabarcelonapb:oai:ddd.uab.cat:241072 2024-09-09T19:57:56+00:00 Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology Skypala, Isabel Asero, Riccardo Barber, Domingo Cecchi, Lorenzo DÃaz-Perales, Araceli Hoffmann-Sommergruber, Karin Pastorello, Elide Anna Swoboda, Ines Bartra, Joan Ebo, Didier Faber, Margaretha A. Fernández-Rivas, Montserrat Gomez, Francisca Konstantinopoulos, Anastasios. P. Luengo Sánchez, Olga van Ree, Ronald Scala, Enrico Till, Stephen J. Universitat Autònoma de Barcelona 2021 application/pdf https://ddd.uab.cat/record/241072 eng eng Clinical and translational allergy Vol. 11 (may 2021) https://ddd.uab.cat/record/241072 urn:10.1002/clt2.12010 urn:oai:ddd.uab.cat:241072 urn:pmcid:PMC8129635 urn:pmc-uid:8129635 urn:pmid:34025983 urn:oai:pubmedcentral.nih.gov:8129635 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Allergy Epidemiology Food Lipid transfer protein LTP Sensitization Article 2021 ftuabarcelonapb 2024-08-06T14:30:50Z Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were "Non-specific Lipid Transfer Proteins", "LTP syndrome", "Pru p 3", "plant food allergy", "pollen-food syndrome". Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or processed. It is unknown why some sensitized individuals develop ... Article in Journal/Newspaper North Atlantic Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
institution |
Open Polar |
collection |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
op_collection_id |
ftuabarcelonapb |
language |
English |
topic |
Allergy Epidemiology Food Lipid transfer protein LTP Sensitization |
spellingShingle |
Allergy Epidemiology Food Lipid transfer protein LTP Sensitization Skypala, Isabel Asero, Riccardo Barber, Domingo Cecchi, Lorenzo DÃaz-Perales, Araceli Hoffmann-Sommergruber, Karin Pastorello, Elide Anna Swoboda, Ines Bartra, Joan Ebo, Didier Faber, Margaretha A. Fernández-Rivas, Montserrat Gomez, Francisca Konstantinopoulos, Anastasios. P. Luengo Sánchez, Olga van Ree, Ronald Scala, Enrico Till, Stephen J. Universitat Autònoma de Barcelona Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
topic_facet |
Allergy Epidemiology Food Lipid transfer protein LTP Sensitization |
description |
Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were "Non-specific Lipid Transfer Proteins", "LTP syndrome", "Pru p 3", "plant food allergy", "pollen-food syndrome". Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or processed. It is unknown why some sensitized individuals develop ... |
format |
Article in Journal/Newspaper |
author |
Skypala, Isabel Asero, Riccardo Barber, Domingo Cecchi, Lorenzo DÃaz-Perales, Araceli Hoffmann-Sommergruber, Karin Pastorello, Elide Anna Swoboda, Ines Bartra, Joan Ebo, Didier Faber, Margaretha A. Fernández-Rivas, Montserrat Gomez, Francisca Konstantinopoulos, Anastasios. P. Luengo Sánchez, Olga van Ree, Ronald Scala, Enrico Till, Stephen J. Universitat Autònoma de Barcelona |
author_facet |
Skypala, Isabel Asero, Riccardo Barber, Domingo Cecchi, Lorenzo DÃaz-Perales, Araceli Hoffmann-Sommergruber, Karin Pastorello, Elide Anna Swoboda, Ines Bartra, Joan Ebo, Didier Faber, Margaretha A. Fernández-Rivas, Montserrat Gomez, Francisca Konstantinopoulos, Anastasios. P. Luengo Sánchez, Olga van Ree, Ronald Scala, Enrico Till, Stephen J. Universitat Autònoma de Barcelona |
author_sort |
Skypala, Isabel |
title |
Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_short |
Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_full |
Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_fullStr |
Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_full_unstemmed |
Non-specific lipid-transfer proteins : Allergen structure and function, cross-reactivity, sensitization, and epidemiology |
title_sort |
non-specific lipid-transfer proteins : allergen structure and function, cross-reactivity, sensitization, and epidemiology |
publishDate |
2021 |
url |
https://ddd.uab.cat/record/241072 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
Clinical and translational allergy Vol. 11 (may 2021) https://ddd.uab.cat/record/241072 urn:10.1002/clt2.12010 urn:oai:ddd.uab.cat:241072 urn:pmcid:PMC8129635 urn:pmc-uid:8129635 urn:pmid:34025983 urn:oai:pubmedcentral.nih.gov:8129635 |
op_rights |
open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1809928890445987840 |