Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation
Fatty alcohols are important products in chemical industry to be used in the formulation of surfactants and lubricants. This work describes a two step approach for the production of myristyl alcohol under neat conditions by combining a lipase catalyzed esterification of myristic acid and myristyl al...
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Online Access: | http://hdl.handle.net/11420/7671 |
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fttuhamburg:oai:tore.tuhh.de:11420/7671 2023-10-01T03:52:09+02:00 Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation Schlipköter, Kim Elisabeth Betke, Tobias Kleber, Joscha Gröger, Harald Liese, Andreas 2020-10-14 http://hdl.handle.net/11420/7671 en eng Organic & biomolecular chemistry 1477-0520 Organic & biomolecular chemistry 39 (18): 7862-7867 (2020-10-14) http://hdl.handle.net/11420/7671 32975273 2-s2.0-85092945184 Journal Article Other 2020 fttuhamburg 2023-09-03T22:13:39Z Fatty alcohols are important products in chemical industry to be used in the formulation of surfactants and lubricants. This work describes a two step approach for the production of myristyl alcohol under neat conditions by combining a lipase catalyzed esterification of myristic acid and myristyl alcohol with a ruthenium catalyzed hydrogenation of the intermediate myristyl myristate. The esterification was carried out in a bubble column reactor with the commercial immobilized lipase B from Candida antarctica as a biocatalyst, while the hydrogenation was conducted under pressurized conditions being catalyzed by the homogeneous chemocatalyst Ru-Macho-BH. By investigating the reaction steps separately, comparable reaction rates were found for the esterification of short chain and long chain alcohols. Additionally, the hydrogen pressure could be reduced to 35 bar compared to the current industrial Lurgi process. Characterization of cross interactions by the reactants myristic acid and sodium myristate in the hydrogenation demonstrates that the metal catalyst was completely deactivated, even at a low amount of 0.5 mol% of myristic acid. Complete conversion of myristic acid in the esterification with equal amounts of myristic acid and myristyl alcohol was obtained, overcoming any limitation in the hydrogenation. In comparison to the Lurgi process starting also from fatty acid and fatty alcohols, the chemoenzymatic two step reaction sequence could be realized at lower reaction temperatures of 60 and 100 °C as well as lower hydrogen pressures of 35 bar. Article in Journal/Newspaper Antarc* Antarctica TUHH Open Research (TORE - Technische Universität Hamburg) Organic & Biomolecular Chemistry 18 39 7862 7867 |
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TUHH Open Research (TORE - Technische Universität Hamburg) |
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English |
description |
Fatty alcohols are important products in chemical industry to be used in the formulation of surfactants and lubricants. This work describes a two step approach for the production of myristyl alcohol under neat conditions by combining a lipase catalyzed esterification of myristic acid and myristyl alcohol with a ruthenium catalyzed hydrogenation of the intermediate myristyl myristate. The esterification was carried out in a bubble column reactor with the commercial immobilized lipase B from Candida antarctica as a biocatalyst, while the hydrogenation was conducted under pressurized conditions being catalyzed by the homogeneous chemocatalyst Ru-Macho-BH. By investigating the reaction steps separately, comparable reaction rates were found for the esterification of short chain and long chain alcohols. Additionally, the hydrogen pressure could be reduced to 35 bar compared to the current industrial Lurgi process. Characterization of cross interactions by the reactants myristic acid and sodium myristate in the hydrogenation demonstrates that the metal catalyst was completely deactivated, even at a low amount of 0.5 mol% of myristic acid. Complete conversion of myristic acid in the esterification with equal amounts of myristic acid and myristyl alcohol was obtained, overcoming any limitation in the hydrogenation. In comparison to the Lurgi process starting also from fatty acid and fatty alcohols, the chemoenzymatic two step reaction sequence could be realized at lower reaction temperatures of 60 and 100 °C as well as lower hydrogen pressures of 35 bar. |
format |
Article in Journal/Newspaper |
author |
Schlipköter, Kim Elisabeth Betke, Tobias Kleber, Joscha Gröger, Harald Liese, Andreas |
spellingShingle |
Schlipköter, Kim Elisabeth Betke, Tobias Kleber, Joscha Gröger, Harald Liese, Andreas Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
author_facet |
Schlipköter, Kim Elisabeth Betke, Tobias Kleber, Joscha Gröger, Harald Liese, Andreas |
author_sort |
Schlipköter, Kim Elisabeth |
title |
Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
title_short |
Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
title_full |
Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
title_fullStr |
Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
title_full_unstemmed |
Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
title_sort |
fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation |
publishDate |
2020 |
url |
http://hdl.handle.net/11420/7671 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
Organic & biomolecular chemistry 1477-0520 Organic & biomolecular chemistry 39 (18): 7862-7867 (2020-10-14) http://hdl.handle.net/11420/7671 32975273 2-s2.0-85092945184 |
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Organic & Biomolecular Chemistry |
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18 |
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39 |
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7862 |
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7867 |
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1778517862270369792 |