Acute necrotizing encephalopathy of childhood: a single-center experience
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of chil...
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2021
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fttubitakaj:oai:journals.tubitak.gov.tr:medical-1321 2023-05-15T18:12:57+02:00 Acute necrotizing encephalopathy of childhood: a single-center experience AKSOY, ERHAN ÖZTOPRAK, ÜLKÜHAN ÇELİK, HALİL ÖZDEMİR, FATİH MEHMET AKİF ÖZKAN, MEHBARE KAYILIOĞLU, HÜLYA DANIŞ, AYŞEGÜL KUCUR, ÖZGE KESİCİ, SELMAN YAZICI, MUTLU UYSAL AZAPAĞASI, EBRU YILDIZ, YASEMİN TAŞCI CEYLAN, NESRİN ŞENEL, SALİHA YÜKSEL, DENİZ 2021-01-01T08:00:00Z application/pdf https://journals.tubitak.gov.tr/medical/vol51/iss2/41 https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1321&context=medical unknown TÜBİTAK Academic Journals https://journals.tubitak.gov.tr/medical/vol51/iss2/41 https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1321&context=medical Turkish Journal of Medical Sciences Febrile illness encephalopathy multifocal brain lesions seizure(s) childhood Medical Sciences text 2021 fttubitakaj 2022-10-19T17:30:52Z Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1-4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study. Text sami TÜBİTAK Academic Journals |
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Febrile illness encephalopathy multifocal brain lesions seizure(s) childhood Medical Sciences |
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Febrile illness encephalopathy multifocal brain lesions seizure(s) childhood Medical Sciences AKSOY, ERHAN ÖZTOPRAK, ÜLKÜHAN ÇELİK, HALİL ÖZDEMİR, FATİH MEHMET AKİF ÖZKAN, MEHBARE KAYILIOĞLU, HÜLYA DANIŞ, AYŞEGÜL KUCUR, ÖZGE KESİCİ, SELMAN YAZICI, MUTLU UYSAL AZAPAĞASI, EBRU YILDIZ, YASEMİN TAŞCI CEYLAN, NESRİN ŞENEL, SALİHA YÜKSEL, DENİZ Acute necrotizing encephalopathy of childhood: a single-center experience |
topic_facet |
Febrile illness encephalopathy multifocal brain lesions seizure(s) childhood Medical Sciences |
description |
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1-4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study. |
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AKSOY, ERHAN ÖZTOPRAK, ÜLKÜHAN ÇELİK, HALİL ÖZDEMİR, FATİH MEHMET AKİF ÖZKAN, MEHBARE KAYILIOĞLU, HÜLYA DANIŞ, AYŞEGÜL KUCUR, ÖZGE KESİCİ, SELMAN YAZICI, MUTLU UYSAL AZAPAĞASI, EBRU YILDIZ, YASEMİN TAŞCI CEYLAN, NESRİN ŞENEL, SALİHA YÜKSEL, DENİZ |
author_facet |
AKSOY, ERHAN ÖZTOPRAK, ÜLKÜHAN ÇELİK, HALİL ÖZDEMİR, FATİH MEHMET AKİF ÖZKAN, MEHBARE KAYILIOĞLU, HÜLYA DANIŞ, AYŞEGÜL KUCUR, ÖZGE KESİCİ, SELMAN YAZICI, MUTLU UYSAL AZAPAĞASI, EBRU YILDIZ, YASEMİN TAŞCI CEYLAN, NESRİN ŞENEL, SALİHA YÜKSEL, DENİZ |
author_sort |
AKSOY, ERHAN |
title |
Acute necrotizing encephalopathy of childhood: a single-center experience |
title_short |
Acute necrotizing encephalopathy of childhood: a single-center experience |
title_full |
Acute necrotizing encephalopathy of childhood: a single-center experience |
title_fullStr |
Acute necrotizing encephalopathy of childhood: a single-center experience |
title_full_unstemmed |
Acute necrotizing encephalopathy of childhood: a single-center experience |
title_sort |
acute necrotizing encephalopathy of childhood: a single-center experience |
publisher |
TÜBİTAK Academic Journals |
publishDate |
2021 |
url |
https://journals.tubitak.gov.tr/medical/vol51/iss2/41 https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1321&context=medical |
genre |
sami |
genre_facet |
sami |
op_source |
Turkish Journal of Medical Sciences |
op_relation |
https://journals.tubitak.gov.tr/medical/vol51/iss2/41 https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1321&context=medical |
_version_ |
1766185436253782016 |