Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring...
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Academy of Science of South Africa
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Online Access: | https://doi.org/10.17159/sajs.2016/20160202 https://doaj.org/article/6b31daded0d44bfd9be0b20cc7fbc943 |
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fttriple:oai:gotriple.eu:oai:doaj.org/article:6b31daded0d44bfd9be0b20cc7fbc943 2023-05-15T13:56:21+02:00 Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean Elisabeth K. Olsen Christopher K. de Cerf Godwin A. Dziwornu Eleonora Puccinelli Isabelle J. Ansorge Toufiek Samaai Laura M.K. Dingle Adrienne L. Edkins Suthananda N. Sunassee 2016-11-01 https://doi.org/10.17159/sajs.2016/20160202 https://doaj.org/article/6b31daded0d44bfd9be0b20cc7fbc943 en eng Academy of Science of South Africa 1996-7489 doi:10.17159/sajs.2016/20160202 https://doaj.org/article/6b31daded0d44bfd9be0b20cc7fbc943 undefined South African Journal of Science, Vol 112, Iss 11/12, Pp 5-5 (2016) multidisciplinary Prince Edward Islands marine natural products cancer cell lines drug discovery geo envir Journal Article https://vocabularies.coar-repositories.org/resource_types/c_6501/ 2016 fttriple https://doi.org/10.17159/sajs.2016/20160202 2023-01-22T19:16:48Z Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: • This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. • This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. • Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. Article in Journal/Newspaper Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean Unknown Antarctic Southern Ocean South African Journal of Science Volume 112 Number 11/12 |
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Open Polar |
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language |
English |
topic |
multidisciplinary Prince Edward Islands marine natural products cancer cell lines drug discovery geo envir |
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multidisciplinary Prince Edward Islands marine natural products cancer cell lines drug discovery geo envir Elisabeth K. Olsen Christopher K. de Cerf Godwin A. Dziwornu Eleonora Puccinelli Isabelle J. Ansorge Toufiek Samaai Laura M.K. Dingle Adrienne L. Edkins Suthananda N. Sunassee Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
topic_facet |
multidisciplinary Prince Edward Islands marine natural products cancer cell lines drug discovery geo envir |
description |
Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: • This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. • This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. • Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. |
format |
Article in Journal/Newspaper |
author |
Elisabeth K. Olsen Christopher K. de Cerf Godwin A. Dziwornu Eleonora Puccinelli Isabelle J. Ansorge Toufiek Samaai Laura M.K. Dingle Adrienne L. Edkins Suthananda N. Sunassee |
author_facet |
Elisabeth K. Olsen Christopher K. de Cerf Godwin A. Dziwornu Eleonora Puccinelli Isabelle J. Ansorge Toufiek Samaai Laura M.K. Dingle Adrienne L. Edkins Suthananda N. Sunassee |
author_sort |
Elisabeth K. Olsen |
title |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_short |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_full |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_fullStr |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_full_unstemmed |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_sort |
cytotoxic activity of marine sponge extracts from the sub-antarctic islands and the southern ocean |
publisher |
Academy of Science of South Africa |
publishDate |
2016 |
url |
https://doi.org/10.17159/sajs.2016/20160202 https://doaj.org/article/6b31daded0d44bfd9be0b20cc7fbc943 |
geographic |
Antarctic Southern Ocean |
geographic_facet |
Antarctic Southern Ocean |
genre |
Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean |
genre_facet |
Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean |
op_source |
South African Journal of Science, Vol 112, Iss 11/12, Pp 5-5 (2016) |
op_relation |
1996-7489 doi:10.17159/sajs.2016/20160202 https://doaj.org/article/6b31daded0d44bfd9be0b20cc7fbc943 |
op_rights |
undefined |
op_doi |
https://doi.org/10.17159/sajs.2016/20160202 |
container_title |
South African Journal of Science |
container_volume |
Volume 112 |
container_issue |
Number 11/12 |
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1766263812286054400 |