Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites
Major histocompatibility complex (MHC) genes are the most polymorphic in vertebrates and code for molecules playing a central role in pathogen resistance. We studied levels of MHC DRB class II diversity in a long-term study population of mountain goats (Oreamnos americanus) at Caw Ridge, Alberta, an...
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fttriple:oai:gotriple.eu:http://hdl.handle.net/20.500.11794/69641 2023-05-15T17:54:12+02:00 Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites Mainguy, Julien Worley, Kirsty Côté, Steeve D. Coltman, David W. Alberta Colombie-Britannique 2006-11-15 https://hdl.handle.net/20.500.11794/69641 en eng Kluwer Academic Publishers http://hdl.handle.net/20.500.11794/69641 other CorpusUL envir hist Journal Article https://vocabularies.coar-repositories.org/resource_types/c_6501/ 2006 fttriple https://doi.org/20.500.11794/69641 2023-01-22T17:40:30Z Major histocompatibility complex (MHC) genes are the most polymorphic in vertebrates and code for molecules playing a central role in pathogen resistance. We studied levels of MHC DRB class II diversity in a long-term study population of mountain goats (Oreamnos americanus) at Caw Ridge, Alberta, and two other populations from British Columbia, Canada. Only two alleles were found among the three populations sampled. The Caw Ridge population was fixed for one of the two MHC DRB alleles, but this lack of variation did not appear to have affected it negatively because the population doubled over two decades and had no history of any apparent infectious diseases. Past population bottlenecks during Pleistocene glaciations are thought to have been the main factor contributing to the low levels of MHC diversity in mountain goats, a hypothesis supported by our previous work reporting low polymorphism at neutral loci. Additionally, the limited MHC variability in mountain goats may be related to its northern distribution as we found that allelic diversity at MHC DRB class II in wild ungulates decreases with increasing latitude, possibly as a result of low parasite diversity at high latitudes. The low MHC variation in mountain goats and other northern ungulates such as muskoxen (Ovibos moschatus) may expose these species to population outbreaks that could be generated by introduced pathogens or northward shifts in the distribution of pathogens with global climate warming. Article in Journal/Newspaper ovibos moschatus Unknown Canada British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) |
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envir hist Mainguy, Julien Worley, Kirsty Côté, Steeve D. Coltman, David W. Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
topic_facet |
envir hist |
description |
Major histocompatibility complex (MHC) genes are the most polymorphic in vertebrates and code for molecules playing a central role in pathogen resistance. We studied levels of MHC DRB class II diversity in a long-term study population of mountain goats (Oreamnos americanus) at Caw Ridge, Alberta, and two other populations from British Columbia, Canada. Only two alleles were found among the three populations sampled. The Caw Ridge population was fixed for one of the two MHC DRB alleles, but this lack of variation did not appear to have affected it negatively because the population doubled over two decades and had no history of any apparent infectious diseases. Past population bottlenecks during Pleistocene glaciations are thought to have been the main factor contributing to the low levels of MHC diversity in mountain goats, a hypothesis supported by our previous work reporting low polymorphism at neutral loci. Additionally, the limited MHC variability in mountain goats may be related to its northern distribution as we found that allelic diversity at MHC DRB class II in wild ungulates decreases with increasing latitude, possibly as a result of low parasite diversity at high latitudes. The low MHC variation in mountain goats and other northern ungulates such as muskoxen (Ovibos moschatus) may expose these species to population outbreaks that could be generated by introduced pathogens or northward shifts in the distribution of pathogens with global climate warming. |
format |
Article in Journal/Newspaper |
author |
Mainguy, Julien Worley, Kirsty Côté, Steeve D. Coltman, David W. |
author_facet |
Mainguy, Julien Worley, Kirsty Côté, Steeve D. Coltman, David W. |
author_sort |
Mainguy, Julien |
title |
Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
title_short |
Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
title_full |
Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
title_fullStr |
Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
title_full_unstemmed |
Low MHC DRB class II diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
title_sort |
low mhc drb class ii diversity in the mountain goat : past bottlenecks and possible role of pathogens and parasites |
publisher |
Kluwer Academic Publishers |
publishDate |
2006 |
url |
https://hdl.handle.net/20.500.11794/69641 |
op_coverage |
Alberta Colombie-Britannique |
long_lat |
ENVELOPE(-125.003,-125.003,54.000,54.000) |
geographic |
Canada British Columbia |
geographic_facet |
Canada British Columbia |
genre |
ovibos moschatus |
genre_facet |
ovibos moschatus |
op_source |
CorpusUL |
op_relation |
http://hdl.handle.net/20.500.11794/69641 |
op_rights |
other |
op_doi |
https://doi.org/20.500.11794/69641 |
_version_ |
1766161921477705728 |