| Summary: | In the Arctic, indigenous populations living off marine mammals and fish consumption may be exposed to high doses of methylmercury (MeHg). Furthermore, since their availability varies over months, there is every reason to believe that exposure to MeHg also varies from month to month. There are still significant knowledge gaps with respect to geographic and temporal variations in MeHg exposure and about country foods responsible for MeHg exposure, particularly for pregnant women in Nunavik. Several findings from the Nunavik Child Development Study highlight that fetal life is a critical moment to prevent MeHg exposure in order to avoid neurodevelopmental outcomes later in childhood. Accordingly, in 2011, the Nunavik Regional Board of Health and Social Services (NRBHSS) released and disseminated a dietary recommendation for pregnant and childbearing age women to reduce their consumption of beluga meat. The aim of the present study was to characterize the geographic and temporal variations in MeHg exposure among Inuit women during pregnancy and to better identify country foods responsible for these variations. This cross-sectional study was carried out with pregnant women aged 16 and over in Nunavik between October 2016 and March 2017. Pregnant women were recruited on a voluntary basis and blood and hair samples were collected. An interview-administered questionnaire was used to gather information on pregnancy, country food frequencies of consumption by season and awareness of public health messages. Blood total Hg was measured using Inductively coupled plasma mass spectrometry (ICP-MS). Hair total Hg was measured by centimeter as a surrogate for monthly exposure using Cold vapor atomic absorption spectrometry (CV-AAS). Multiple regressions analyses were done to assess the seasonal variation and the regional difference of mercury (Hg) levels. A latent class growth analysis was conducted to identify pregnant women with similar monthly trajectories in hair Hg levels over time. Based on the MeHg concentrations in ...
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