Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their upta...
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fttriple:oai:gotriple.eu:http://hdl.handle.net/20.500.11794/27559 2023-05-15T16:54:59+02:00 Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik Metabolomic biomarkers in relation to behavioural problems with young Inuit from Nunavik St-Jean, Audray Lucas, Michel Ayotte, Pierre Québec (Province) 2016-01-01 https://hdl.handle.net/20.500.11794/27559 fr fre Université Laval http://hdl.handle.net/20.500.11794/27559 other CorpusUL psy socio Thesis https://vocabularies.coar-repositories.org/resource_types/c_46ec/ 2016 fttriple https://doi.org/20.500.11794/27559 2023-01-22T18:26:42Z Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their uptake into the brain is competitive with respect to the uptake of BCAAs via their transport through the same carrier, we explored the relationship between metabolomic biomarkers (BCAAs and AAAs) and behavioral problems among young Inuit from Nunavik. The current analysis includes 141 youth who participated in the Nunavik Child Development Study baseline (2005-2010) and adolescent follow-up (2013-2015). BCAA and AAA plasma concentrations were measured at baseline and categorised in tertiles of the ratio of BCAAs to AAAs (BCAA/AAA). Behavioral problems were assessed during adolescence with the Youth Self-Report (YSR) from the Child Behavior Checklist (CBCL). The relationship between tertiles of BCAA/AAA and mean scores of YSR syndromes was assessed with general linear models. We noted a trend toward a higher mean scores of internalizing problems (Ptrend=0.05) and somatic complaints (Ptrend=0.01) syndromes with higher BCAA/AAA ratio. No statistically-significant relationship was noted for externalizing and attention problems scores. We observed higher (Ptrend < 0.05) internalizing problems and somatic complaints syndrome scores with a higher ratio of BCAA/AAA among normal weight participants, but not among overweight or obese. Our results suggest that an elevated BCAA/AAA ratio is associated with behavioral problems among youth, mainly internalizing problems. L’obésité et la résistance à l’insuline sont associées avec les troubles de l’humeur ainsi que des concentrations plasmatiques élevées en acides aminés ramifiés (BCAAs : isoleucine, leucine et valine) et en acides aminés aromatiques (AAAs : phénylalanine et tyrosine). Étant donné que les AAAs sont des précurseurs de neurotransmetteurs clés et que leur apport au ... Thesis inuit Nunavik Unknown Nunavik |
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Open Polar |
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op_collection_id |
fttriple |
language |
French |
topic |
psy socio |
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psy socio St-Jean, Audray Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
topic_facet |
psy socio |
description |
Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their uptake into the brain is competitive with respect to the uptake of BCAAs via their transport through the same carrier, we explored the relationship between metabolomic biomarkers (BCAAs and AAAs) and behavioral problems among young Inuit from Nunavik. The current analysis includes 141 youth who participated in the Nunavik Child Development Study baseline (2005-2010) and adolescent follow-up (2013-2015). BCAA and AAA plasma concentrations were measured at baseline and categorised in tertiles of the ratio of BCAAs to AAAs (BCAA/AAA). Behavioral problems were assessed during adolescence with the Youth Self-Report (YSR) from the Child Behavior Checklist (CBCL). The relationship between tertiles of BCAA/AAA and mean scores of YSR syndromes was assessed with general linear models. We noted a trend toward a higher mean scores of internalizing problems (Ptrend=0.05) and somatic complaints (Ptrend=0.01) syndromes with higher BCAA/AAA ratio. No statistically-significant relationship was noted for externalizing and attention problems scores. We observed higher (Ptrend < 0.05) internalizing problems and somatic complaints syndrome scores with a higher ratio of BCAA/AAA among normal weight participants, but not among overweight or obese. Our results suggest that an elevated BCAA/AAA ratio is associated with behavioral problems among youth, mainly internalizing problems. L’obésité et la résistance à l’insuline sont associées avec les troubles de l’humeur ainsi que des concentrations plasmatiques élevées en acides aminés ramifiés (BCAAs : isoleucine, leucine et valine) et en acides aminés aromatiques (AAAs : phénylalanine et tyrosine). Étant donné que les AAAs sont des précurseurs de neurotransmetteurs clés et que leur apport au ... |
author2 |
Lucas, Michel Ayotte, Pierre |
format |
Thesis |
author |
St-Jean, Audray |
author_facet |
St-Jean, Audray |
author_sort |
St-Jean, Audray |
title |
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
title_short |
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
title_full |
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
title_fullStr |
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
title_full_unstemmed |
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik |
title_sort |
biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes inuit du nunavik |
publisher |
Université Laval |
publishDate |
2016 |
url |
https://hdl.handle.net/20.500.11794/27559 |
op_coverage |
Québec (Province) |
geographic |
Nunavik |
geographic_facet |
Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
CorpusUL |
op_relation |
http://hdl.handle.net/20.500.11794/27559 |
op_rights |
other |
op_doi |
https://doi.org/20.500.11794/27559 |
_version_ |
1766045947364638720 |