Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik

Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their upta...

Full description

Bibliographic Details
Main Author: St-Jean, Audray
Other Authors: Lucas, Michel, Ayotte, Pierre
Format: Thesis
Language:French
Published: Université Laval 2016
Subjects:
psy
Online Access:https://hdl.handle.net/20.500.11794/27559
id fttriple:oai:gotriple.eu:http://hdl.handle.net/20.500.11794/27559
record_format openpolar
spelling fttriple:oai:gotriple.eu:http://hdl.handle.net/20.500.11794/27559 2023-05-15T16:54:59+02:00 Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik Metabolomic biomarkers in relation to behavioural problems with young Inuit from Nunavik St-Jean, Audray Lucas, Michel Ayotte, Pierre Québec (Province) 2016-01-01 https://hdl.handle.net/20.500.11794/27559 fr fre Université Laval http://hdl.handle.net/20.500.11794/27559 other CorpusUL psy socio Thesis https://vocabularies.coar-repositories.org/resource_types/c_46ec/ 2016 fttriple https://doi.org/20.500.11794/27559 2023-01-22T18:26:42Z Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their uptake into the brain is competitive with respect to the uptake of BCAAs via their transport through the same carrier, we explored the relationship between metabolomic biomarkers (BCAAs and AAAs) and behavioral problems among young Inuit from Nunavik. The current analysis includes 141 youth who participated in the Nunavik Child Development Study baseline (2005-2010) and adolescent follow-up (2013-2015). BCAA and AAA plasma concentrations were measured at baseline and categorised in tertiles of the ratio of BCAAs to AAAs (BCAA/AAA). Behavioral problems were assessed during adolescence with the Youth Self-Report (YSR) from the Child Behavior Checklist (CBCL). The relationship between tertiles of BCAA/AAA and mean scores of YSR syndromes was assessed with general linear models. We noted a trend toward a higher mean scores of internalizing problems (Ptrend=0.05) and somatic complaints (Ptrend=0.01) syndromes with higher BCAA/AAA ratio. No statistically-significant relationship was noted for externalizing and attention problems scores. We observed higher (Ptrend < 0.05) internalizing problems and somatic complaints syndrome scores with a higher ratio of BCAA/AAA among normal weight participants, but not among overweight or obese. Our results suggest that an elevated BCAA/AAA ratio is associated with behavioral problems among youth, mainly internalizing problems. L’obésité et la résistance à l’insuline sont associées avec les troubles de l’humeur ainsi que des concentrations plasmatiques élevées en acides aminés ramifiés (BCAAs : isoleucine, leucine et valine) et en acides aminés aromatiques (AAAs : phénylalanine et tyrosine). Étant donné que les AAAs sont des précurseurs de neurotransmetteurs clés et que leur apport au ... Thesis inuit Nunavik Unknown Nunavik
institution Open Polar
collection Unknown
op_collection_id fttriple
language French
topic psy
socio
spellingShingle psy
socio
St-Jean, Audray
Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
topic_facet psy
socio
description Obesity and insulin resistance are associated with mood disorders and elevated plasma concentrations of branched-chain amino acids (BCAAs: isoleucine, leucine and valine), and aromatic amino acids (AAAs: phenylalanine and tyrosine). Because AAAs are precursors of key neurotransmitters and their uptake into the brain is competitive with respect to the uptake of BCAAs via their transport through the same carrier, we explored the relationship between metabolomic biomarkers (BCAAs and AAAs) and behavioral problems among young Inuit from Nunavik. The current analysis includes 141 youth who participated in the Nunavik Child Development Study baseline (2005-2010) and adolescent follow-up (2013-2015). BCAA and AAA plasma concentrations were measured at baseline and categorised in tertiles of the ratio of BCAAs to AAAs (BCAA/AAA). Behavioral problems were assessed during adolescence with the Youth Self-Report (YSR) from the Child Behavior Checklist (CBCL). The relationship between tertiles of BCAA/AAA and mean scores of YSR syndromes was assessed with general linear models. We noted a trend toward a higher mean scores of internalizing problems (Ptrend=0.05) and somatic complaints (Ptrend=0.01) syndromes with higher BCAA/AAA ratio. No statistically-significant relationship was noted for externalizing and attention problems scores. We observed higher (Ptrend < 0.05) internalizing problems and somatic complaints syndrome scores with a higher ratio of BCAA/AAA among normal weight participants, but not among overweight or obese. Our results suggest that an elevated BCAA/AAA ratio is associated with behavioral problems among youth, mainly internalizing problems. L’obésité et la résistance à l’insuline sont associées avec les troubles de l’humeur ainsi que des concentrations plasmatiques élevées en acides aminés ramifiés (BCAAs : isoleucine, leucine et valine) et en acides aminés aromatiques (AAAs : phénylalanine et tyrosine). Étant donné que les AAAs sont des précurseurs de neurotransmetteurs clés et que leur apport au ...
author2 Lucas, Michel
Ayotte, Pierre
format Thesis
author St-Jean, Audray
author_facet St-Jean, Audray
author_sort St-Jean, Audray
title Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
title_short Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
title_full Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
title_fullStr Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
title_full_unstemmed Biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes Inuit du Nunavik
title_sort biomarqueurs métabolomiques en relation avec les problèmes de comportement auprès de jeunes inuit du nunavik
publisher Université Laval
publishDate 2016
url https://hdl.handle.net/20.500.11794/27559
op_coverage Québec (Province)
geographic Nunavik
geographic_facet Nunavik
genre inuit
Nunavik
genre_facet inuit
Nunavik
op_source CorpusUL
op_relation http://hdl.handle.net/20.500.11794/27559
op_rights other
op_doi https://doi.org/20.500.11794/27559
_version_ 1766045947364638720