Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study

• Published in: Psychiatry Research: Neuroimaging
• Main Authors: Huhtaniska, Sanna, Jaaskelainen, Erika, Heikka, Tuomas, Moilanen, Jani S., Lehtiniemi, Heli, Tohka, Jussi, Manjón Herrera, José Vicente, Coupe, Pierrick, Bjornholm, Lassi, Koponen, Hannu, Veijola, Juha, Isohanni, Matti, Kiviniemi, Vesa, Murray, Graham K., Miettunen, Jouko
• Other Authors: Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Banco Santander, University of Oulu, Academy of Finland, Orion Research Foundation, Sigrid Jusélius Foundation, Universidad Carlos III de Madrid, Jalmari and Rauha Ahokas Foundation, Brain and Behavior Research Foundation, Ministerio de Economía y Competitividad, Ministerio de Educación, Cultura y Deporte
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2017
• Subjects: demo; envir; Orion; Sigrid; Northern Finland
• Online Access: https://doi.org/10.1016/j.pscychresns.2017.05.009; http://hdl.handle.net/10251/154106

S [EN] High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortalit...