Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including bir...
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Online Access: | https://doi.org/10.5061/dryad.934fg |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::ecd6cdb0d43eb01804f05296ee349474 2023-05-15T14:17:08+02:00 Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes McGaugh, Suzanne Schwartz, Tonia S. 2020-07-13 https://doi.org/10.5061/dryad.934fg undefined unknown Dryad Digital Repository https://dx.doi.org/10.5061/dryad.934fg http://dx.doi.org/10.5061/dryad.934fg lic_creative-commons 10.5061/dryad.934fg oai:easy.dans.knaw.nl:easy-dataset:96386 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:96386 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c UCP1 thermogenesis cetacean lizard snake turtle Agkistrodon piscivorus Ailuropoda melanoleuca Alligator mississippiensis Alligator sinensis Anas platyrhynchos Anolis carolinensis Anolis sagrei Anser cygnoides domesticus Apaloderma vittatum Aptenodytes forsteri Aquila chrysaetos canadensis Balaenoptera acutorostrata Balearica regulorum gibbericeps Bos taurus Buceros rhinoceros silvestris Callithrix jacchus Calypte anna Candoia aspera Canis familiaris Caprimulgus carolinensis Cariama cristata Cavia porcellus Chaetura pelagica Charadrius vociferus Chelonia mydas Cheyldra serpentina Chlamydotis macqueenii Chlorocebus sabaeus Choloepus hoffmanni Chrysemys picta Colius striatus Columba livia Corvus brachyrhynchos Corvus cornix cornix Crocodylus porosusæ Cuculus canorus Dasypus novemcinctus Dipodomys ordii Echinops telfairi Egretta garzetta Elgaria multicarinata Equus caballus Erinaceus europaeus Eublepharis macularius Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2020 fttriple https://doi.org/10.5061/dryad.934fg 2023-01-22T17:41:53Z Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. Supplemental_File1_Methods_Results_FiguresDetailed description of methods and results including figures S1 and S2.Supplemental_File2_TablesThis is a summary of results for each species analyzed in our study, including presence of ucp1 annotation, synteny analysis, and blasting of raw reads. This table also includes the ftp links to the sequence data used for each species. Species highlighted in purple had no evidence of ucp1 in Ensembl and were investigated further through synteny analysis and BLAST search of their raw data.Supplemental_File3_BlastQUERY_SyntenyThe exon sequences for ucp1 and six flanking genes used in the BLASTn for synteny analysis.Supplemental_File4_Protein_UCP1_Query_for_TBLASTNThe UCP1 protein sequences used for tBLASTn against the genomes.Supplemental_File5_BlastQUERY_for_raw_reads_mammalsThe ucp1 gene sequences used for BLASTn against the raw sequence data for ... Dataset Aptenodytes forsteri Balaenoptera acutorostrata Orca Aquila chrysaetos Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
unknown |
topic |
UCP1 thermogenesis cetacean lizard snake turtle Agkistrodon piscivorus Ailuropoda melanoleuca Alligator mississippiensis Alligator sinensis Anas platyrhynchos Anolis carolinensis Anolis sagrei Anser cygnoides domesticus Apaloderma vittatum Aptenodytes forsteri Aquila chrysaetos canadensis Balaenoptera acutorostrata Balearica regulorum gibbericeps Bos taurus Buceros rhinoceros silvestris Callithrix jacchus Calypte anna Candoia aspera Canis familiaris Caprimulgus carolinensis Cariama cristata Cavia porcellus Chaetura pelagica Charadrius vociferus Chelonia mydas Cheyldra serpentina Chlamydotis macqueenii Chlorocebus sabaeus Choloepus hoffmanni Chrysemys picta Colius striatus Columba livia Corvus brachyrhynchos Corvus cornix cornix Crocodylus porosusæ Cuculus canorus Dasypus novemcinctus Dipodomys ordii Echinops telfairi Egretta garzetta Elgaria multicarinata Equus caballus Erinaceus europaeus Eublepharis macularius |
spellingShingle |
UCP1 thermogenesis cetacean lizard snake turtle Agkistrodon piscivorus Ailuropoda melanoleuca Alligator mississippiensis Alligator sinensis Anas platyrhynchos Anolis carolinensis Anolis sagrei Anser cygnoides domesticus Apaloderma vittatum Aptenodytes forsteri Aquila chrysaetos canadensis Balaenoptera acutorostrata Balearica regulorum gibbericeps Bos taurus Buceros rhinoceros silvestris Callithrix jacchus Calypte anna Candoia aspera Canis familiaris Caprimulgus carolinensis Cariama cristata Cavia porcellus Chaetura pelagica Charadrius vociferus Chelonia mydas Cheyldra serpentina Chlamydotis macqueenii Chlorocebus sabaeus Choloepus hoffmanni Chrysemys picta Colius striatus Columba livia Corvus brachyrhynchos Corvus cornix cornix Crocodylus porosusæ Cuculus canorus Dasypus novemcinctus Dipodomys ordii Echinops telfairi Egretta garzetta Elgaria multicarinata Equus caballus Erinaceus europaeus Eublepharis macularius McGaugh, Suzanne Schwartz, Tonia S. Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
topic_facet |
UCP1 thermogenesis cetacean lizard snake turtle Agkistrodon piscivorus Ailuropoda melanoleuca Alligator mississippiensis Alligator sinensis Anas platyrhynchos Anolis carolinensis Anolis sagrei Anser cygnoides domesticus Apaloderma vittatum Aptenodytes forsteri Aquila chrysaetos canadensis Balaenoptera acutorostrata Balearica regulorum gibbericeps Bos taurus Buceros rhinoceros silvestris Callithrix jacchus Calypte anna Candoia aspera Canis familiaris Caprimulgus carolinensis Cariama cristata Cavia porcellus Chaetura pelagica Charadrius vociferus Chelonia mydas Cheyldra serpentina Chlamydotis macqueenii Chlorocebus sabaeus Choloepus hoffmanni Chrysemys picta Colius striatus Columba livia Corvus brachyrhynchos Corvus cornix cornix Crocodylus porosusæ Cuculus canorus Dasypus novemcinctus Dipodomys ordii Echinops telfairi Egretta garzetta Elgaria multicarinata Equus caballus Erinaceus europaeus Eublepharis macularius |
description |
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although ucp1 arose early in the vertebrate lineage, the loss of ucp1 was previously documented in several reptile species (including birds). Here we determine that ucp1 was lost at the base of the reptile lineage, as we fail to find ucp1 in every major reptile lineage. Furthermore, though UCP1 plays a key role in mammalian NST, we confirm that pig has lost several exons from ucp1 and conclude that pig is not a sole outlier as the only eutherian mammal lineage to do so. Through similarity searches and synteny analysis, we show that ucp1 has also been lost/pseudogenized in Delphinidae (dolphin, orca) and potentially Xenarthra (sloth, armadillo) and Afrotheria (hyrax). These lineages provide models for investigating alternate mechanisms of thermoregulation and energy metabolism in the absence of functional UCP1. Further, the repeated losses of a functional UCP1 suggest the pervasiveness of NST via UCP1 across the mammalian lineage needs re-evaluation. Supplemental_File1_Methods_Results_FiguresDetailed description of methods and results including figures S1 and S2.Supplemental_File2_TablesThis is a summary of results for each species analyzed in our study, including presence of ucp1 annotation, synteny analysis, and blasting of raw reads. This table also includes the ftp links to the sequence data used for each species. Species highlighted in purple had no evidence of ucp1 in Ensembl and were investigated further through synteny analysis and BLAST search of their raw data.Supplemental_File3_BlastQUERY_SyntenyThe exon sequences for ucp1 and six flanking genes used in the BLASTn for synteny analysis.Supplemental_File4_Protein_UCP1_Query_for_TBLASTNThe UCP1 protein sequences used for tBLASTn against the genomes.Supplemental_File5_BlastQUERY_for_raw_reads_mammalsThe ucp1 gene sequences used for BLASTn against the raw sequence data for ... |
format |
Dataset |
author |
McGaugh, Suzanne Schwartz, Tonia S. |
author_facet |
McGaugh, Suzanne Schwartz, Tonia S. |
author_sort |
McGaugh, Suzanne |
title |
Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_short |
Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_full |
Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_fullStr |
Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_full_unstemmed |
Data from: Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
title_sort |
data from: here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes |
publisher |
Dryad Digital Repository |
publishDate |
2020 |
url |
https://doi.org/10.5061/dryad.934fg |
genre |
Aptenodytes forsteri Balaenoptera acutorostrata Orca Aquila chrysaetos |
genre_facet |
Aptenodytes forsteri Balaenoptera acutorostrata Orca Aquila chrysaetos |
op_source |
10.5061/dryad.934fg oai:easy.dans.knaw.nl:easy-dataset:96386 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:96386 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
https://dx.doi.org/10.5061/dryad.934fg http://dx.doi.org/10.5061/dryad.934fg |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.934fg |
_version_ |
1766289061128962048 |