Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Ma...
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Online Access: | https://doi.org/10.5061/dryad.j4h65 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::e096a536ef7a70d0eb16d5e30fd6e19d 2023-05-15T15:30:30+02:00 Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. 2017-01-01 https://doi.org/10.5061/dryad.j4h65 en eng Dryad http://dx.doi.org/10.5061/dryad.j4h65 https://dx.doi.org/10.5061/dryad.j4h65 lic_creative-commons 10.5061/dryad.j4h65 oai:easy.dans.knaw.nl:easy-dataset:99974 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:99974 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 life-stage Transcriptomics Salmo salar Fish Metabolism Life sciences medicine and health care Adaptation envir socio Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2017 fttriple https://doi.org/10.5061/dryad.j4h65 https://doi.org/10.5061/DRYAD.J4H65 2023-01-22T16:50:56Z Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism Supplementary_files_Harvey_et_al_MEC-17-0821This zip file contains 10 supplementary files associated to Harvey et al. "Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon". Dataset Atlantic salmon Salmo salar Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
English |
topic |
life-stage Transcriptomics Salmo salar Fish Metabolism Life sciences medicine and health care Adaptation envir socio |
spellingShingle |
life-stage Transcriptomics Salmo salar Fish Metabolism Life sciences medicine and health care Adaptation envir socio Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
topic_facet |
life-stage Transcriptomics Salmo salar Fish Metabolism Life sciences medicine and health care Adaptation envir socio |
description |
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism Supplementary_files_Harvey_et_al_MEC-17-0821This zip file contains 10 supplementary files associated to Harvey et al. "Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon". |
format |
Dataset |
author |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. |
author_facet |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Sandve, Simen R. |
author_sort |
Gillard, Gareth |
title |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_short |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_fullStr |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full_unstemmed |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_sort |
data from: life-stage associated remodeling of lipid metabolism regulation in atlantic salmon |
publisher |
Dryad |
publishDate |
2017 |
url |
https://doi.org/10.5061/dryad.j4h65 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
10.5061/dryad.j4h65 oai:easy.dans.knaw.nl:easy-dataset:99974 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:99974 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 |
op_relation |
http://dx.doi.org/10.5061/dryad.j4h65 https://dx.doi.org/10.5061/dryad.j4h65 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.j4h65 https://doi.org/10.5061/DRYAD.J4H65 |
_version_ |
1766360960499449856 |