Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas
The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to...
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fttriple:oai:gotriple.eu:50|dedup_wf_001::d705f309fcf89190c402e50ff06c7afa 2023-05-15T15:57:50+02:00 Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas Plough, Louis V. 2012-01-01 https://doi.org/10.5061/dryad.376jg undefined unknown http://dx.doi.org/10.5061/dryad.376jg https://dx.doi.org/10.5061/dryad.376jg lic_creative-commons oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:81882 oai:easy.dans.knaw.nl:easy-dataset:81882 10.5061/dryad.376jg 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f re3data_____::r3d100000044 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c Life sciences medicine and health care deleterious mutations selection Experimental genetics Crassostrea gigas QTL mapping Conservation Genetics Inbreeding depression envir archeo Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2012 fttriple https://doi.org/10.5061/dryad.376jg 2023-01-22T17:22:27Z The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to what extent the fitness of individual deleterious mutations is altered under stress. Using microsatellite marker segregation data and quantitative trait locus (QTL) mapping methods, I performed a genome scan for deleterious mutations affecting viability (viability or vQTL) in two, inbred families of the Pacific oyster Crassostrea gigas, reared in a stressful, nutrient-poor diet and a favorable, nutrient-rich diet, which had significant effects on growth and survival. Twice as many vQTL were detected in the stressful diet compared with the favorable diet, resulting primarily from substantially greater mortality of homozygous genotypes. At vQTL, estimates of selection (s) and dominance (h) were significantly greater in the stressful environment (s ̅ = 0.86 vs. 0.54 and h ̅ = 0.35 vs. 0.18, in stressful and non-stressful diets, respectively). There was no evidence of interaction between vQTL. Individual vQTL differed across diets in selection only, or in both selection and dominance, and some vQTL were not affected by diet. These results suggest that stress-associated increases in selection against individual deleterious alleles underlie greater inbreeding depression with stress. Furthermore, the finding that inbreeding-by-environment interaction appears, to some extent, to be locus-specific, helps to explain previous observations of lineage-specific expression of inbreeding depression and environment-specific purging, which have important implications for conservation and evolutionary biology. Microsatellite genotypes for Mol. Ecology environmental stress study in C. gigas 5_23_12 Dataset Crassostrea gigas Pacific oyster Unknown Pacific |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
unknown |
topic |
Life sciences medicine and health care deleterious mutations selection Experimental genetics Crassostrea gigas QTL mapping Conservation Genetics Inbreeding depression envir archeo |
spellingShingle |
Life sciences medicine and health care deleterious mutations selection Experimental genetics Crassostrea gigas QTL mapping Conservation Genetics Inbreeding depression envir archeo Plough, Louis V. Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
topic_facet |
Life sciences medicine and health care deleterious mutations selection Experimental genetics Crassostrea gigas QTL mapping Conservation Genetics Inbreeding depression envir archeo |
description |
The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to what extent the fitness of individual deleterious mutations is altered under stress. Using microsatellite marker segregation data and quantitative trait locus (QTL) mapping methods, I performed a genome scan for deleterious mutations affecting viability (viability or vQTL) in two, inbred families of the Pacific oyster Crassostrea gigas, reared in a stressful, nutrient-poor diet and a favorable, nutrient-rich diet, which had significant effects on growth and survival. Twice as many vQTL were detected in the stressful diet compared with the favorable diet, resulting primarily from substantially greater mortality of homozygous genotypes. At vQTL, estimates of selection (s) and dominance (h) were significantly greater in the stressful environment (s ̅ = 0.86 vs. 0.54 and h ̅ = 0.35 vs. 0.18, in stressful and non-stressful diets, respectively). There was no evidence of interaction between vQTL. Individual vQTL differed across diets in selection only, or in both selection and dominance, and some vQTL were not affected by diet. These results suggest that stress-associated increases in selection against individual deleterious alleles underlie greater inbreeding depression with stress. Furthermore, the finding that inbreeding-by-environment interaction appears, to some extent, to be locus-specific, helps to explain previous observations of lineage-specific expression of inbreeding depression and environment-specific purging, which have important implications for conservation and evolutionary biology. Microsatellite genotypes for Mol. Ecology environmental stress study in C. gigas 5_23_12 |
format |
Dataset |
author |
Plough, Louis V. |
author_facet |
Plough, Louis V. |
author_sort |
Plough, Louis V. |
title |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_short |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_full |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_fullStr |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_full_unstemmed |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_sort |
data from: environmental stress increases selection against and dominance of deleterious mutations in inbred families of the pacific oyster crassostrea gigas |
publishDate |
2012 |
url |
https://doi.org/10.5061/dryad.376jg |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:81882 oai:easy.dans.knaw.nl:easy-dataset:81882 10.5061/dryad.376jg 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f re3data_____::r3d100000044 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
http://dx.doi.org/10.5061/dryad.376jg https://dx.doi.org/10.5061/dryad.376jg |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.376jg |
_version_ |
1766393542298566656 |