Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating
A variety of nonrandom mate choice strategies, including disassortative mating, are used by vertebrate species to avoid inbreeding, maintain heterozygosity and increase fitness. Disassortative mating may be mediated by the major histocompatibility complex (MHC), an important gene cluster controlling...
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English |
topic |
Original Articles Canis lupus fitness major histocompatibility complex mate choice microsatellites sexual selection envir psy |
spellingShingle |
Original Articles Canis lupus fitness major histocompatibility complex mate choice microsatellites sexual selection envir psy Ettore Randi Marco Galaverni Romolo Caniglia Elena Fabbri Silvana Lapalombella Pietro Milanesi Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
topic_facet |
Original Articles Canis lupus fitness major histocompatibility complex mate choice microsatellites sexual selection envir psy |
description |
A variety of nonrandom mate choice strategies, including disassortative mating, are used by vertebrate species to avoid inbreeding, maintain heterozygosity and increase fitness. Disassortative mating may be mediated by the major histocompatibility complex (MHC), an important gene cluster controlling immune responses to pathogens. We investigated the patterns of mate choice in 26 wild-living breeding pairs of gray wolf (Canis lupus) that were identified through noninvasive genetic methods and genotyped at 3 MHC class II and 12 autosomal microsatellite (STR) loci. We tested for deviations from random mating and evaluated the covariance of genetic variables at functional and STR markers with fitness proxies deduced from pedigree reconstructions. Results did not show evidences of MHC-based disassortative mating. Rather we found a higher peptide similarity between mates at MHC loci as compared with random expectations. Fitness values were positively correlated with heterozygosity of the breeders at both MHC and STR loci, whereas they decreased with relatedness at STRs. These findings may indicate fitness advantages for breeders that, while avoiding highly related mates, are more similar at the MHC and have high levels of heterozygosity overall. Such a pattern of MHC-assortative mating may reflect local coadaptation of the breeders, while a reduction in genetic diversity may be balanced by heterozygote advantages. |
format |
Article in Journal/Newspaper |
author |
Ettore Randi Marco Galaverni Romolo Caniglia Elena Fabbri Silvana Lapalombella Pietro Milanesi |
author_facet |
Ettore Randi Marco Galaverni Romolo Caniglia Elena Fabbri Silvana Lapalombella Pietro Milanesi |
author_sort |
Ettore Randi |
title |
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
title_short |
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
title_full |
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
title_fullStr |
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
title_full_unstemmed |
Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating |
title_sort |
choosy wolves? heterozygote advantage but no evidence of mhc-based disassortative mating |
publisher |
Oxford University Press |
publishDate |
2015 |
url |
http://academic.oup.com/jhered/article-pdf/107/2/134/19551755/esv090.pdf https://academic.oup.com/jhered/article-pdf/107/2/134/25024711/esv090.pdf https://europepmc.org/articles/PMC5994966/ https://doi.org/10.1093/jhered/esv090 https://www.ncbi.nlm.nih.gov/pubmed/26610365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994966 http://europepmc.org/abstract/MED/26610365 https://academic.oup.com/jhered/article/107/2/134/2622858 https://vbn.aau.dk/en/publications/choosy-wolves-heterozygote-advantage-but-no-evidence-of-mhc-based http://academic.oup.com/jhered/article-abstract/107/2/134/2622858 https://jhered.oxfordjournals.org/content/early/2015/11/25/jhered.esv090.abstract https://academic.microsoft.com/#/detail/2184011699 https://vbn.aau.dk/da/publications/3b0fb4ed-6c44-4371-b104-6046ec82912f http://hdl.handle.net/11585/535268 |
genre |
Canis lupus gray wolf |
genre_facet |
Canis lupus gray wolf |
op_source |
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op_relation |
http://academic.oup.com/jhered/article-pdf/107/2/134/19551755/esv090.pdf https://academic.oup.com/jhered/article-pdf/107/2/134/25024711/esv090.pdf https://europepmc.org/articles/PMC5994966/ https://dx.doi.org/10.1093/jhered/esv090 http://dx.doi.org/10.1093/jhered/esv090 https://www.ncbi.nlm.nih.gov/pubmed/26610365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994966 http://europepmc.org/abstract/MED/26610365 https://academic.oup.com/jhered/article/107/2/134/2622858 https://vbn.aau.dk/en/publications/choosy-wolves-heterozygote-advantage-but-no-evidence-of-mhc-based http://academic.oup.com/jhered/article-abstract/107/2/134/2622858 https://jhered.oxfordjournals.org/content/early/2015/11/25/jhered.esv090.abstract https://academic.microsoft.com/#/detail/2184011699 https://vbn.aau.dk/da/publications/3b0fb4ed-6c44-4371-b104-6046ec82912f http://hdl.handle.net/11585/535268 |
op_rights |
undefined |
op_doi |
https://doi.org/10.1093/jhered/esv090 |
container_title |
Journal of Heredity |
container_volume |
107 |
container_issue |
2 |
container_start_page |
134 |
op_container_end_page |
142 |
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1766384818959941632 |
spelling |
fttriple:oai:gotriple.eu:50|dedup_wf_001::cb049f6f4d355af74545a6405e44a42c 2023-05-15T15:49:48+02:00 Choosy Wolves? Heterozygote Advantage But No Evidence of MHC-Based Disassortative Mating Ettore Randi Marco Galaverni Romolo Caniglia Elena Fabbri Silvana Lapalombella Pietro Milanesi 2015-11-25 http://academic.oup.com/jhered/article-pdf/107/2/134/19551755/esv090.pdf https://academic.oup.com/jhered/article-pdf/107/2/134/25024711/esv090.pdf https://europepmc.org/articles/PMC5994966/ https://doi.org/10.1093/jhered/esv090 https://www.ncbi.nlm.nih.gov/pubmed/26610365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994966 http://europepmc.org/abstract/MED/26610365 https://academic.oup.com/jhered/article/107/2/134/2622858 https://vbn.aau.dk/en/publications/choosy-wolves-heterozygote-advantage-but-no-evidence-of-mhc-based http://academic.oup.com/jhered/article-abstract/107/2/134/2622858 https://jhered.oxfordjournals.org/content/early/2015/11/25/jhered.esv090.abstract https://academic.microsoft.com/#/detail/2184011699 https://vbn.aau.dk/da/publications/3b0fb4ed-6c44-4371-b104-6046ec82912f http://hdl.handle.net/11585/535268 en eng Oxford University Press http://academic.oup.com/jhered/article-pdf/107/2/134/19551755/esv090.pdf https://academic.oup.com/jhered/article-pdf/107/2/134/25024711/esv090.pdf https://europepmc.org/articles/PMC5994966/ https://dx.doi.org/10.1093/jhered/esv090 http://dx.doi.org/10.1093/jhered/esv090 https://www.ncbi.nlm.nih.gov/pubmed/26610365 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994966 http://europepmc.org/abstract/MED/26610365 https://academic.oup.com/jhered/article/107/2/134/2622858 https://vbn.aau.dk/en/publications/choosy-wolves-heterozygote-advantage-but-no-evidence-of-mhc-based http://academic.oup.com/jhered/article-abstract/107/2/134/2622858 https://jhered.oxfordjournals.org/content/early/2015/11/25/jhered.esv090.abstract https://academic.microsoft.com/#/detail/2184011699 https://vbn.aau.dk/da/publications/3b0fb4ed-6c44-4371-b104-6046ec82912f http://hdl.handle.net/11585/535268 undefined oai:pubmedcentral.nih.gov:5994966 10.1093/jhered/esv090 26610365 2184011699 oai:pure.atira.dk:publications/3b0fb4ed-6c44-4371-b104-6046ec82912f oai:cris.unibo.it:11585/535268 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 openaire____::1256f046-bf1f-4afc-8b47-d0b147148b18 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|issn___print::662bd97507eb11635097f6fd0f439ea2 10|openaire____::8ac8380272269217cb09a928c8caa993 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a 10|opendoar____::8e2cfdc275761edc592f73a076197c33 10|opendoar____::64c53a52cb3bd1a01c03a64db985c0cc 10|openaire____::55045bd2a65019fd8e6741a755395c8c 10|openaire____::806360c771262b4d6770e7cdf04b5c5a Original Articles Canis lupus fitness major histocompatibility complex mate choice microsatellites sexual selection envir psy Journal Article https://vocabularies.coar-repositories.org/resource_types/c_6501/ 2015 fttriple https://doi.org/10.1093/jhered/esv090 2023-01-22T16:59:00Z A variety of nonrandom mate choice strategies, including disassortative mating, are used by vertebrate species to avoid inbreeding, maintain heterozygosity and increase fitness. Disassortative mating may be mediated by the major histocompatibility complex (MHC), an important gene cluster controlling immune responses to pathogens. We investigated the patterns of mate choice in 26 wild-living breeding pairs of gray wolf (Canis lupus) that were identified through noninvasive genetic methods and genotyped at 3 MHC class II and 12 autosomal microsatellite (STR) loci. We tested for deviations from random mating and evaluated the covariance of genetic variables at functional and STR markers with fitness proxies deduced from pedigree reconstructions. Results did not show evidences of MHC-based disassortative mating. Rather we found a higher peptide similarity between mates at MHC loci as compared with random expectations. Fitness values were positively correlated with heterozygosity of the breeders at both MHC and STR loci, whereas they decreased with relatedness at STRs. These findings may indicate fitness advantages for breeders that, while avoiding highly related mates, are more similar at the MHC and have high levels of heterozygosity overall. Such a pattern of MHC-assortative mating may reflect local coadaptation of the breeders, while a reduction in genetic diversity may be balanced by heterozygote advantages. Article in Journal/Newspaper Canis lupus gray wolf Unknown Journal of Heredity 107 2 134 142 |