Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross
Reduced fitness of admixed individuals is typically attributed to genetic incompatibilities. Although mismatched genomes can lead to fitness changes, in some cases the reduction in hybrid fitness is subtle. The potential role of transcriptional regulation in admixed genomes could provide a mechanist...
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Online Access: | https://doi.org/10.5061/dryad.18sg7 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::b093acd1c19945b9ce1f436da1bbf186 2023-05-15T16:22:52+02:00 Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross vonHoldt, Bridgett Heppenheimer, Elizabeth Petrenko, Vladimir Croonquist, Paula Rutledge, Linda Y. 2017-01-01 https://doi.org/10.5061/dryad.18sg7 en eng Dryad http://dx.doi.org/10.5061/dryad.18sg7 https://dx.doi.org/10.5061/dryad.18sg7 lic_creative-commons 10.5061/dryad.18sg7 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:96959 oai:easy.dans.knaw.nl:easy-dataset:96959 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 ancestry admixture Methylation Canis canid Holocene North America Life sciences medicine and health care envir socio Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2017 fttriple https://doi.org/10.5061/dryad.18sg7 2023-01-22T16:51:21Z Reduced fitness of admixed individuals is typically attributed to genetic incompatibilities. Although mismatched genomes can lead to fitness changes, in some cases the reduction in hybrid fitness is subtle. The potential role of transcriptional regulation in admixed genomes could provide a mechanistic explanation for these discrepancies, but evidence is lacking for non-model organisms.Here, we explored the intersection of genetics and gene regulation in admixed genomes derived from an experimental cross between a western gray wolf and western coyote. We found a significant positive association between methylation and wolf ancestry, and identified outlier genes that have been previously implicated in inbreeding-related, or otherwise deleterious, phenotypes. We describe a pattern of site-specific, rather than genome-wide, methylation driven by inter-specific hybridization. Epigenetic variation is thus suggested to play a non-trivial role in both maintaining and combating mismatched genotypes through putative transcriptional mechanisms. We conclude that the regulation of gene expression is an underappreciated key component of hybrid genome functioning, but could also act as a potential source of novel and beneficial adaptive variation in hybrid offspring. wyoteMeth_10x_3mil_sites_MFThis file contains the methylation frequency (MF, number of cytosines out of the total read coverage) per site for a coyote, wolves, and their hybrid offspring. This dataset contains ~3 million cytosines.Wyotes_15733_GBS_SNPsThis file contains SNP genotypes for 15,733 sites generated by GBS for a coyote, wolves, and their hybrid offspring. Dataset gray wolf Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
English |
topic |
ancestry admixture Methylation Canis canid Holocene North America Life sciences medicine and health care envir socio |
spellingShingle |
ancestry admixture Methylation Canis canid Holocene North America Life sciences medicine and health care envir socio vonHoldt, Bridgett Heppenheimer, Elizabeth Petrenko, Vladimir Croonquist, Paula Rutledge, Linda Y. Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
topic_facet |
ancestry admixture Methylation Canis canid Holocene North America Life sciences medicine and health care envir socio |
description |
Reduced fitness of admixed individuals is typically attributed to genetic incompatibilities. Although mismatched genomes can lead to fitness changes, in some cases the reduction in hybrid fitness is subtle. The potential role of transcriptional regulation in admixed genomes could provide a mechanistic explanation for these discrepancies, but evidence is lacking for non-model organisms.Here, we explored the intersection of genetics and gene regulation in admixed genomes derived from an experimental cross between a western gray wolf and western coyote. We found a significant positive association between methylation and wolf ancestry, and identified outlier genes that have been previously implicated in inbreeding-related, or otherwise deleterious, phenotypes. We describe a pattern of site-specific, rather than genome-wide, methylation driven by inter-specific hybridization. Epigenetic variation is thus suggested to play a non-trivial role in both maintaining and combating mismatched genotypes through putative transcriptional mechanisms. We conclude that the regulation of gene expression is an underappreciated key component of hybrid genome functioning, but could also act as a potential source of novel and beneficial adaptive variation in hybrid offspring. wyoteMeth_10x_3mil_sites_MFThis file contains the methylation frequency (MF, number of cytosines out of the total read coverage) per site for a coyote, wolves, and their hybrid offspring. This dataset contains ~3 million cytosines.Wyotes_15733_GBS_SNPsThis file contains SNP genotypes for 15,733 sites generated by GBS for a coyote, wolves, and their hybrid offspring. |
format |
Dataset |
author |
vonHoldt, Bridgett Heppenheimer, Elizabeth Petrenko, Vladimir Croonquist, Paula Rutledge, Linda Y. |
author_facet |
vonHoldt, Bridgett Heppenheimer, Elizabeth Petrenko, Vladimir Croonquist, Paula Rutledge, Linda Y. |
author_sort |
vonHoldt, Bridgett |
title |
Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
title_short |
Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
title_full |
Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
title_fullStr |
Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
title_full_unstemmed |
Data from: Ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
title_sort |
data from: ancestry-specific methylation patterns in admixed offspring from an experimental coyote and gray wolf cross |
publisher |
Dryad |
publishDate |
2017 |
url |
https://doi.org/10.5061/dryad.18sg7 |
genre |
gray wolf |
genre_facet |
gray wolf |
op_source |
10.5061/dryad.18sg7 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:96959 oai:easy.dans.knaw.nl:easy-dataset:96959 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 |
op_relation |
http://dx.doi.org/10.5061/dryad.18sg7 https://dx.doi.org/10.5061/dryad.18sg7 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.18sg7 |
_version_ |
1766010990352138240 |