Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird
BauchBeckerVerhulst_MolEcol_Long-telomeres-better-predict-fitness-proxiesData Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescenc...
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Data Archiving and Networked Services (DANS)
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Online Access: | https://doi.org/10.5061/dryad.k8r75 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::af4f2a4b2dca66c7f40650c89db9e075 2023-05-15T18:27:23+02:00 Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird Bauch, Christina Becker, Peter H. Verhulst, Simon 2013-01-01 https://doi.org/10.5061/dryad.k8r75 undefined unknown Data Archiving and Networked Services (DANS) http://dx.doi.org/10.5061/dryad.k8r75 https://dx.doi.org/10.5061/dryad.k8r75 lic_creative-commons oai:easy.dans.knaw.nl:easy-dataset:84815 10.5061/dryad.k8r75 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:84815 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c Life sciences medicine and health care ageing selective disappearance life-history lifestyle reproduction Birds Wilhelmshaven Germany Sterna hirundo envir psy Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2013 fttriple https://doi.org/10.5061/dryad.k8r75 2023-01-22T16:51:37Z BauchBeckerVerhulst_MolEcol_Long-telomeres-better-predict-fitness-proxiesData Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. Dataset Sterna hirundo Unknown |
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Open Polar |
collection |
Unknown |
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fttriple |
language |
unknown |
topic |
Life sciences medicine and health care ageing selective disappearance life-history lifestyle reproduction Birds Wilhelmshaven Germany Sterna hirundo envir psy |
spellingShingle |
Life sciences medicine and health care ageing selective disappearance life-history lifestyle reproduction Birds Wilhelmshaven Germany Sterna hirundo envir psy Bauch, Christina Becker, Peter H. Verhulst, Simon Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
topic_facet |
Life sciences medicine and health care ageing selective disappearance life-history lifestyle reproduction Birds Wilhelmshaven Germany Sterna hirundo envir psy |
description |
BauchBeckerVerhulst_MolEcol_Long-telomeres-better-predict-fitness-proxiesData Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. |
format |
Dataset |
author |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_facet |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_sort |
Bauch, Christina |
title |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_short |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_fullStr |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full_unstemmed |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_sort |
data from: within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
publisher |
Data Archiving and Networked Services (DANS) |
publishDate |
2013 |
url |
https://doi.org/10.5061/dryad.k8r75 |
genre |
Sterna hirundo |
genre_facet |
Sterna hirundo |
op_source |
oai:easy.dans.knaw.nl:easy-dataset:84815 10.5061/dryad.k8r75 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:84815 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
http://dx.doi.org/10.5061/dryad.k8r75 https://dx.doi.org/10.5061/dryad.k8r75 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.k8r75 |
_version_ |
1766209464992530432 |