Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds
Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomar...
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Online Access: | https://doi.org/10.5061/dryad.ft6fv |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::71c637432ac1fe56aab6658fd2f101ae 2023-05-15T15:51:08+02:00 Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja Lundgren Willesen, Jakob Mejer Sørensen, Louise 2015-01-01 https://doi.org/10.5061/dryad.ft6fv undefined unknown Dryad Digital Repository https://dx.doi.org/10.5061/dryad.ft6fv http://dx.doi.org/10.5061/dryad.ft6fv lic_creative-commons 10.5061/dryad.ft6fv oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:86732 oai:easy.dans.knaw.nl:easy-dataset:86732 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 re3data_____::r3d100000044 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c GWAS breed specific sweep epistasis Canis lupus familiaris canine fructosamine gene-gene interaction diabetes dog Belgian shepherd breed Sweden France Belgium Denmark Finland Life sciences medicine and health care envir psy Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2015 fttriple https://doi.org/10.5061/dryad.ft6fv 2023-01-22T17:23:56Z Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus. Dataset Canis lupus Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
unknown |
topic |
GWAS breed specific sweep epistasis Canis lupus familiaris canine fructosamine gene-gene interaction diabetes dog Belgian shepherd breed Sweden France Belgium Denmark Finland Life sciences medicine and health care envir psy |
spellingShingle |
GWAS breed specific sweep epistasis Canis lupus familiaris canine fructosamine gene-gene interaction diabetes dog Belgian shepherd breed Sweden France Belgium Denmark Finland Life sciences medicine and health care envir psy Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja Lundgren Willesen, Jakob Mejer Sørensen, Louise Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
topic_facet |
GWAS breed specific sweep epistasis Canis lupus familiaris canine fructosamine gene-gene interaction diabetes dog Belgian shepherd breed Sweden France Belgium Denmark Finland Life sciences medicine and health care envir psy |
description |
Forsberg et al. Fructosamine dataForsberg_et_al_fructosamine_data.zip Diabetes mellitus is a serious health problem in both dogs and humans. Certain dog breeds show high prevalence of the disease, whereas other breeds are at low risk. Fructosamine and glycated hemoglobin (HbA1c) are two major biomarkers of glycaemia where serum concentrations reflect glucose turnover over the past few weeks to months. In this study, we searched for genetic factors influencing variation in serum fructosamine concentration in healthy dogs using data from nine dog breeds. Considering all breeds together, we did not find any genome-wide significant associations to fructosamine serum concentration. However, by performing breed-specific analyses we revealed an association on CFA 3 (pcorrected ≈ 1.68 × 10−6) in Belgian shepherd dogs. The associated region and its close neighborhood harbours interesting candidate genes such as LETM1 and GAPDH that are important in glucose metabolism and have previously been implicated in the aetiology of diabetes mellitus. To further explore the genetics of this breed specificity, we screened the genome for reduced heterozygosity stretches private to the Belgian shepherd breed. This revealed a region with reduced heterozygosity that shows a statistically significant interaction (p = 0.025) with the association region on CFA3. This region also harbours some interesting candidate genes and regulatory regions but the exact mechanisms underlying the interaction are still unknown. Nevertheless, this finding provides a plausible explanation for breed-specific genetic effects for complex traits in dogs. Shepherd breeds are at low risk of developing diabetes mellitus. The findings in Belgian shepherds could be connected to a protective mechanism against the disease. Further insight into the regulation of glucose metabolism could improve diagnostic and therapeutic methods for diabetes mellitus. |
format |
Dataset |
author |
Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja Lundgren Willesen, Jakob Mejer Sørensen, Louise |
author_facet |
Forsberg, Simon K. G. Kierczak, Marcin Ljungvall, Ingrid Merveille, Anne-Christine Gouni, Vassiliki Wiberg, Maria Willesen, Jakob Lundgren Hanås, Sofia Lequarré, Anne-Sophie Sørensen, Louise Mejer Tiret, Laurent McEntee, Kathleen Seppälä, Eija Koch, Jørgen Battaille, Géraldine Lohi, Hannes Fredholm, Merete Chetboul, Valerie Häggström, Jens Carlborg, Örjan Lindblad-Toh, Kerstin Höglund, Katja Lundgren Willesen, Jakob Mejer Sørensen, Louise |
author_sort |
Forsberg, Simon K. G. |
title |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_short |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_full |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_fullStr |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_full_unstemmed |
Data from: The shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in Belgian shepherds |
title_sort |
data from: the shepherds' tale: a genome-wide study across 9 dog breeds implicates two loci in the regulation of fructosamine serum concentration in belgian shepherds |
publisher |
Dryad Digital Repository |
publishDate |
2015 |
url |
https://doi.org/10.5061/dryad.ft6fv |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
10.5061/dryad.ft6fv oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:86732 oai:easy.dans.knaw.nl:easy-dataset:86732 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 re3data_____::r3d100000044 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
https://dx.doi.org/10.5061/dryad.ft6fv http://dx.doi.org/10.5061/dryad.ft6fv |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.ft6fv |
_version_ |
1766386192149905408 |