Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an import...
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Original Article Genetics(clinical) Genetics envir anthro-se |
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Original Article Genetics(clinical) Genetics envir anthro-se Håvard Bakke Harald Grove Serap Gonen Stephen Bishop Ross D. Houston Petter Arnesen Matthew Baranski Ashie Norris Ingunn Thorland Sigbjørn Lien Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
topic_facet |
Original Article Genetics(clinical) Genetics envir anthro-se |
description |
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h2~0.5; post-smolt POP 2 h2~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant proportion of host genetic variation in resistance to PD in both populations, suggesting a common underlying mechanism for genetic resistance across lifecycle stages. Markers associated with this QTL are being incorporated into selective breeding programs to improve PD resistance. |
format |
Article in Journal/Newspaper |
author |
Håvard Bakke Harald Grove Serap Gonen Stephen Bishop Ross D. Houston Petter Arnesen Matthew Baranski Ashie Norris Ingunn Thorland Sigbjørn Lien |
author_facet |
Håvard Bakke Harald Grove Serap Gonen Stephen Bishop Ross D. Houston Petter Arnesen Matthew Baranski Ashie Norris Ingunn Thorland Sigbjørn Lien |
author_sort |
Håvard Bakke |
title |
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_short |
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_full |
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_fullStr |
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) |
title_sort |
mapping and validation of a major qtl affecting resistance to pancreas disease (salmonid alphavirus) in atlantic salmon (salmo salar) |
publishDate |
2015 |
url |
https://www.pure.ed.ac.uk/ws/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://www.nature.com/articles/hdy201537.pdf https://www.nature.com/articles/hdy201537.pdf http://www.research.ed.ac.uk/portal/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://hdl.handle.net/11250/2374891 http://europepmc.org/articles/PMC4611234 https://doi.org/10.1038/hdy.2015.37 http://www.nature.com/articles/hdy201537 https://www.ncbi.nlm.nih.gov/pubmed/25990876 https://core.ac.uk/display/43713596 https://brage.bibsys.no/xmlui/handle/11250/2380426 https://www.research.ed.ac.uk/portal/en/publications/mapping-and-validation-of-a-major-qtl-affecting-resistance-to-pancreas-disease-salmonid-alphavirus-in-atlantic-salmon-salmo-salar(962c5741-cb8a-466a-8e5c-19f9e7fe2971).html https://academic.microsoft.com/#/detail/1482490553 |
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ENVELOPE(156.400,156.400,68.817,68.817) |
geographic |
Sav’ |
geographic_facet |
Sav’ |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::4b872c33e4429f21175977cf6b0dfa84 2023-05-15T15:30:55+02:00 Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar) Håvard Bakke Harald Grove Serap Gonen Stephen Bishop Ross D. Houston Petter Arnesen Matthew Baranski Ashie Norris Ingunn Thorland Sigbjørn Lien 2015-05-20 https://www.pure.ed.ac.uk/ws/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://www.nature.com/articles/hdy201537.pdf https://www.nature.com/articles/hdy201537.pdf http://www.research.ed.ac.uk/portal/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://hdl.handle.net/11250/2374891 http://europepmc.org/articles/PMC4611234 https://doi.org/10.1038/hdy.2015.37 http://www.nature.com/articles/hdy201537 https://www.ncbi.nlm.nih.gov/pubmed/25990876 https://core.ac.uk/display/43713596 https://brage.bibsys.no/xmlui/handle/11250/2380426 https://www.research.ed.ac.uk/portal/en/publications/mapping-and-validation-of-a-major-qtl-affecting-resistance-to-pancreas-disease-salmonid-alphavirus-in-atlantic-salmon-salmo-salar(962c5741-cb8a-466a-8e5c-19f9e7fe2971).html https://academic.microsoft.com/#/detail/1482490553 en eng https://www.pure.ed.ac.uk/ws/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://www.nature.com/articles/hdy201537.pdf https://www.nature.com/articles/hdy201537.pdf http://www.research.ed.ac.uk/portal/files/19623122/Mapping_and_validation_of_a_major_QTL_affecting_resistance_to_pancreas_disease_salmonid_alphavirus_in_Atlantic_salmon_Salmo_salar_.pdf http://hdl.handle.net/11250/2374891 http://europepmc.org/articles/PMC4611234 http://dx.doi.org/10.1038/hdy.2015.37 https://dx.doi.org/10.1038/hdy.2015.37 http://www.nature.com/articles/hdy201537 https://www.ncbi.nlm.nih.gov/pubmed/25990876 https://core.ac.uk/display/43713596 https://brage.bibsys.no/xmlui/handle/11250/2380426 https://www.research.ed.ac.uk/portal/en/publications/mapping-and-validation-of-a-major-qtl-affecting-resistance-to-pancreas-disease-salmonid-alphavirus-in-atlantic-salmon-salmo-salar(962c5741-cb8a-466a-8e5c-19f9e7fe2971).html https://academic.microsoft.com/#/detail/1482490553 lic_creative-commons oai:brage.bibsys.no:11250/2374891 10.1038/hdy.2015.37 oai:pubmedcentral.nih.gov:4611234 oai:pure.ed.ac.uk:publications/962c5741-cb8a-466a-8e5c-19f9e7fe2971 oai:nmbu.brage.unit.no:11250/2380426 BFhdy201537 1482490553 25990876 oai:nofima.brage.unit.no:11250/2374891 10|driver______::4dc196be332447baf11e431bd838e81c 10|openaire____::96c67b8f18814e8428a958028cf5bcc1 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|openaire____::55045bd2a65019fd8e6741a755395c8c 10|opendoar____::512fc3c5227f637e41437c999a2d3169 10|opendoar____::d16509f6eaca1022bd8f28d6bc582cae 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|issn___print::3e88400688618df3a76d97c1b1aa49e1 10|openaire____::8ac8380272269217cb09a928c8caa993 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a openaire____::1256f046-bf1f-4afc-8b47-d0b147148b18 10|opendoar____::ac4e7a4f341e7281b0f6f274f9ec3905 Original Article Genetics(clinical) Genetics envir anthro-se Journal Article https://vocabularies.coar-repositories.org/resource_types/c_6501/ Conference Output https://vocabularies.coar-repositories.org/resource_types/c_c94f/ 2015 fttriple https://doi.org/10.1038/hdy.2015.37 2023-01-22T17:08:37Z Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h2~0.5; post-smolt POP 2 h2~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant proportion of host genetic variation in resistance to PD in both populations, suggesting a common underlying mechanism for genetic resistance across lifecycle stages. Markers associated with this QTL are being incorporated into selective breeding programs to improve PD resistance. Article in Journal/Newspaper Atlantic salmon Salmo salar Unknown Sav’ ENVELOPE(156.400,156.400,68.817,68.817) Heredity 115 5 405 414 |