Data from: Epigenetic estimation of age in humpback whales
Age is a fundamental aspect of animal ecology, but is difficult to determine in many species. Humpback whales exemplify this as they have a lifespan comparable to humans, mature sexually as early as four years and have no reliable visual age indicators after their first year. Current methods for est...
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Data Archiving and Networked Services (DANS)
2014
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Online Access: | https://doi.org/10.5061/dryad.h4b48 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::3f666b32f23428f9f51f832fd8616095 2023-05-15T16:36:10+02:00 Data from: Epigenetic estimation of age in humpback whales Polanowski, Andrea M. Robbins, Jooke Chandler, David Jarman, Simon N. 2014-01-01 https://doi.org/10.5061/dryad.h4b48 undefined unknown Data Archiving and Networked Services (DANS) http://dx.doi.org/10.5061/dryad.h4b48 https://dx.doi.org/10.5061/dryad.h4b48 lic_creative-commons oai:easy.dans.knaw.nl:easy-dataset:84987 10.5061/dryad.h4b48 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:84987 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 re3data_____::r3d100000044 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c Life sciences medicine and health care Anthropocene Population Ecology Megaptera novaengliae Ecological Genetics Wildlife Management Mammals Gulf of Maine East coast Australia West coast Australia envir archeo Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2014 fttriple https://doi.org/10.5061/dryad.h4b48 2023-01-22T17:08:24Z Age is a fundamental aspect of animal ecology, but is difficult to determine in many species. Humpback whales exemplify this as they have a lifespan comparable to humans, mature sexually as early as four years and have no reliable visual age indicators after their first year. Current methods for estimating humpback age cannot be applied to all individuals and populations. Assays for human age have recently been developed recently based on age-induced changes in DNA methylation of specific genes. We used information on age-associated DNA methylation in human and mouse genes to identify homologous gene regions in humpbacks. Humpback skin samples were obtained from individuals with a known year of birth and employed to calibrate relationships between cytosine methylation and age. Seven of 37 cytosines assayed for methylation level in humpback skin had significant age-related profiles. The three most age-informative cytosine markers were selected for a humpback epigenetic age assay. The assay has an R2 of 0.787 (p = 3.04e-16) and predicts age from skin samples with a standard deviation of 2.991 years. The epigenetic method correctly determined which of parent-offspring pairs is the parent in more than 93% of cases. To demonstrate the potential of this technique, we constructed the first modern age profile of humpback whales off eastern Australia and compared the results to population structure five decades earlier. This is the first epigenetic age estimation method for a wild animal species and the approach we took for developing it can be applied to many other non model organisms. HEAA_MER_Data+ScriptsThis .zip archive contains two directories. The 'Data' directory contains the measured levels of CpG methylation at various places in the humpback whale genome. The 'Scripts' directory contains the R scripts used to analyse this data. Dataset Humpback Whale Unknown |
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Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
unknown |
topic |
Life sciences medicine and health care Anthropocene Population Ecology Megaptera novaengliae Ecological Genetics Wildlife Management Mammals Gulf of Maine East coast Australia West coast Australia envir archeo |
spellingShingle |
Life sciences medicine and health care Anthropocene Population Ecology Megaptera novaengliae Ecological Genetics Wildlife Management Mammals Gulf of Maine East coast Australia West coast Australia envir archeo Polanowski, Andrea M. Robbins, Jooke Chandler, David Jarman, Simon N. Data from: Epigenetic estimation of age in humpback whales |
topic_facet |
Life sciences medicine and health care Anthropocene Population Ecology Megaptera novaengliae Ecological Genetics Wildlife Management Mammals Gulf of Maine East coast Australia West coast Australia envir archeo |
description |
Age is a fundamental aspect of animal ecology, but is difficult to determine in many species. Humpback whales exemplify this as they have a lifespan comparable to humans, mature sexually as early as four years and have no reliable visual age indicators after their first year. Current methods for estimating humpback age cannot be applied to all individuals and populations. Assays for human age have recently been developed recently based on age-induced changes in DNA methylation of specific genes. We used information on age-associated DNA methylation in human and mouse genes to identify homologous gene regions in humpbacks. Humpback skin samples were obtained from individuals with a known year of birth and employed to calibrate relationships between cytosine methylation and age. Seven of 37 cytosines assayed for methylation level in humpback skin had significant age-related profiles. The three most age-informative cytosine markers were selected for a humpback epigenetic age assay. The assay has an R2 of 0.787 (p = 3.04e-16) and predicts age from skin samples with a standard deviation of 2.991 years. The epigenetic method correctly determined which of parent-offspring pairs is the parent in more than 93% of cases. To demonstrate the potential of this technique, we constructed the first modern age profile of humpback whales off eastern Australia and compared the results to population structure five decades earlier. This is the first epigenetic age estimation method for a wild animal species and the approach we took for developing it can be applied to many other non model organisms. HEAA_MER_Data+ScriptsThis .zip archive contains two directories. The 'Data' directory contains the measured levels of CpG methylation at various places in the humpback whale genome. The 'Scripts' directory contains the R scripts used to analyse this data. |
format |
Dataset |
author |
Polanowski, Andrea M. Robbins, Jooke Chandler, David Jarman, Simon N. |
author_facet |
Polanowski, Andrea M. Robbins, Jooke Chandler, David Jarman, Simon N. |
author_sort |
Polanowski, Andrea M. |
title |
Data from: Epigenetic estimation of age in humpback whales |
title_short |
Data from: Epigenetic estimation of age in humpback whales |
title_full |
Data from: Epigenetic estimation of age in humpback whales |
title_fullStr |
Data from: Epigenetic estimation of age in humpback whales |
title_full_unstemmed |
Data from: Epigenetic estimation of age in humpback whales |
title_sort |
data from: epigenetic estimation of age in humpback whales |
publisher |
Data Archiving and Networked Services (DANS) |
publishDate |
2014 |
url |
https://doi.org/10.5061/dryad.h4b48 |
genre |
Humpback Whale |
genre_facet |
Humpback Whale |
op_source |
oai:easy.dans.knaw.nl:easy-dataset:84987 10.5061/dryad.h4b48 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:84987 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 re3data_____::r3d100000044 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
http://dx.doi.org/10.5061/dryad.h4b48 https://dx.doi.org/10.5061/dryad.h4b48 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.h4b48 |
_version_ |
1766026471639351296 |