Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska
For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the...
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Dryad
2020
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Online Access: | https://doi.org/10.5061/dryad.dc1q8 https://doi.org/10.5061/dryad.dc1q8.2 https://doi.org/10.5061/dryad.dc1q8.1 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::24216deacf9aaf0218890f38d201185f 2023-05-15T14:31:13+02:00 Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten 2020-07-23 https://doi.org/10.5061/dryad.dc1q8 https://doi.org/10.5061/dryad.dc1q8.2 https://doi.org/10.5061/dryad.dc1q8.1 en eng Dryad http://dx.doi.org/10.5061/dryad.dc1q8 https://dx.doi.org/10.5061/dryad.dc1q8 http://dx.doi.org/10.5061/dryad.dc1q8.2 https://dx.doi.org/10.5061/dryad.dc1q8.2 http://dx.doi.org/10.5061/dryad.dc1q8.1 https://dx.doi.org/10.5061/dryad.dc1q8.1 lic_creative-commons 10.5061/dryad.dc1q8 oai:easy.dans.knaw.nl:easy-dataset:92108 10.5061/dryad.dc1q8.2 10.5061/dryad.dc1q8.1 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:118632 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:92108 oai:easy.dans.knaw.nl:easy-dataset:118632 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c gene flow Vulpes lagopus Boreal tundra Holocene disease transmission Vulpes vulpes Life sciences medicine and health care Alaska envir geo Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2020 fttriple https://doi.org/10.5061/dryad.dc1q8 https://doi.org/10.5061/dryad.dc1q8.2 https://doi.org/10.5061/dryad.dc1q8.1 2023-01-22T17:23:35Z For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes (Vulpes lagopus) and red foxes (V. vulpes) in order to possibly distinguish reservoir and spill over hosts. We used mitochondrial DNA (mtDNA) sequence and nine microsatellites to assess population structure in those two species. mtDNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found 2 groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising 2 regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine-scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the artic fox Therefore we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. Goldsmith et al fox dataDNA sequence data and microsatellite genotypes for red and arctic foxes, a Newick tree file of rabies virus variants from Alaska, and two Arlequin project files for data analysis.Goldsmith_et_al_fox_data_12_15.zip Dataset Arctic Fox Arctic Tundra Vulpes lagopus Alaska Unknown Arctic |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
English |
topic |
gene flow Vulpes lagopus Boreal tundra Holocene disease transmission Vulpes vulpes Life sciences medicine and health care Alaska envir geo |
spellingShingle |
gene flow Vulpes lagopus Boreal tundra Holocene disease transmission Vulpes vulpes Life sciences medicine and health care Alaska envir geo Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
topic_facet |
gene flow Vulpes lagopus Boreal tundra Holocene disease transmission Vulpes vulpes Life sciences medicine and health care Alaska envir geo |
description |
For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes (Vulpes lagopus) and red foxes (V. vulpes) in order to possibly distinguish reservoir and spill over hosts. We used mitochondrial DNA (mtDNA) sequence and nine microsatellites to assess population structure in those two species. mtDNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found 2 groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising 2 regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine-scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the artic fox Therefore we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. Goldsmith et al fox dataDNA sequence data and microsatellite genotypes for red and arctic foxes, a Newick tree file of rabies virus variants from Alaska, and two Arlequin project files for data analysis.Goldsmith_et_al_fox_data_12_15.zip |
format |
Dataset |
author |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
author_facet |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
author_sort |
Goldsmith, Elizabeth W. |
title |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_short |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_fullStr |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full_unstemmed |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_sort |
data from: population structure of two rabies hosts relative to the known distribution of rabies virus variants in alaska |
publisher |
Dryad |
publishDate |
2020 |
url |
https://doi.org/10.5061/dryad.dc1q8 https://doi.org/10.5061/dryad.dc1q8.2 https://doi.org/10.5061/dryad.dc1q8.1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Tundra Vulpes lagopus Alaska |
genre_facet |
Arctic Fox Arctic Tundra Vulpes lagopus Alaska |
op_source |
10.5061/dryad.dc1q8 oai:easy.dans.knaw.nl:easy-dataset:92108 10.5061/dryad.dc1q8.2 10.5061/dryad.dc1q8.1 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:118632 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:92108 oai:easy.dans.knaw.nl:easy-dataset:118632 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 re3data_____::r3d100000044 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c |
op_relation |
http://dx.doi.org/10.5061/dryad.dc1q8 https://dx.doi.org/10.5061/dryad.dc1q8 http://dx.doi.org/10.5061/dryad.dc1q8.2 https://dx.doi.org/10.5061/dryad.dc1q8.2 http://dx.doi.org/10.5061/dryad.dc1q8.1 https://dx.doi.org/10.5061/dryad.dc1q8.1 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.dc1q8 https://doi.org/10.5061/dryad.dc1q8.2 https://doi.org/10.5061/dryad.dc1q8.1 |
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