Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs
Androgens have benefits, such as promoting muscle growth, but also significant costs, including suppression of immune function. In many species, these trade-offs in androgen action are reflected in regulated androgen production, which is typically highest only in reproductive males. However, all non...
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fttriple:oai:gotriple.eu:50|dedup_wf_001::04978a5a8e994a1a490e13f153e6e555 2023-05-15T14:31:28+02:00 Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs Boonstra, Rudy Mo, Kaiguo Monks, Douglas Ashley Mo, K. Monks, D. A. Boonstra, R. 2020-07-05 https://doi.org/10.5061/dryad.mt35d undefined unknown http://dx.doi.org/10.5061/dryad.mt35d https://dx.doi.org/10.5061/dryad.mt35d lic_creative-commons oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:87240 10.5061/dryad.mt35d oai:easy.dans.knaw.nl:easy-dataset:87240 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 Life sciences medicine and health care androgen receptors adrenal androgens life history tradeoffs muscle anabolism and catabolism Yukon Alberta 2009 Urocitellus columbianus Urocitellus parryii envir socio Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2020 fttriple https://doi.org/10.5061/dryad.mt35d 2023-01-22T16:51:33Z Androgens have benefits, such as promoting muscle growth, but also significant costs, including suppression of immune function. In many species, these trade-offs in androgen action are reflected in regulated androgen production, which is typically highest only in reproductive males. However, all non-reproductive Arctic ground squirrels, irrespective of age and sex, have high levels of androgens prior to hibernating at sub-zero temperatures. Androgens appear to be required to make muscle in summer, which, together with lipid, is then catabolized during overwinter. By contrast, most hibernating mammals catabolize only lipid. We tested the hypothesis that androgen action is selectively enhanced in Arctic ground squirrel muscle because of an upregulation of androgen receptors (ARs). Using Western blot analysis, we found that Arctic ground squirrels have AR in skeletal muscle more than four times that of Columbian ground squirrels, a related southern species that overwinters at approximately 0°C and has low pre-hibernation androgen levels. By contrast, AR in lymph nodes was equivalent in both species. Brain AR was also modestly but significantly increased in Arctic ground squirrel relative to Columbian ground squirrel. These results are consistent with the hypothesis that tissue-specific AR regulation prior to hibernation provides a mechanism whereby Arctic ground squirrels obtain the life-history benefits and mitigate the costs associated with high androgen production. AR.ags.cgs.trapping datatrapping data of the animals contributing contributing to the researchmonks.AR.Master.dataAndrogen receptor analysis that is the basis of the paper from the squirrels used Dataset Arctic ground squirrel Arctic Urocitellus parryii Yukon Unknown Arctic Yukon |
institution |
Open Polar |
collection |
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op_collection_id |
fttriple |
language |
unknown |
topic |
Life sciences medicine and health care androgen receptors adrenal androgens life history tradeoffs muscle anabolism and catabolism Yukon Alberta 2009 Urocitellus columbianus Urocitellus parryii envir socio |
spellingShingle |
Life sciences medicine and health care androgen receptors adrenal androgens life history tradeoffs muscle anabolism and catabolism Yukon Alberta 2009 Urocitellus columbianus Urocitellus parryii envir socio Boonstra, Rudy Mo, Kaiguo Monks, Douglas Ashley Mo, K. Monks, D. A. Boonstra, R. Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
topic_facet |
Life sciences medicine and health care androgen receptors adrenal androgens life history tradeoffs muscle anabolism and catabolism Yukon Alberta 2009 Urocitellus columbianus Urocitellus parryii envir socio |
description |
Androgens have benefits, such as promoting muscle growth, but also significant costs, including suppression of immune function. In many species, these trade-offs in androgen action are reflected in regulated androgen production, which is typically highest only in reproductive males. However, all non-reproductive Arctic ground squirrels, irrespective of age and sex, have high levels of androgens prior to hibernating at sub-zero temperatures. Androgens appear to be required to make muscle in summer, which, together with lipid, is then catabolized during overwinter. By contrast, most hibernating mammals catabolize only lipid. We tested the hypothesis that androgen action is selectively enhanced in Arctic ground squirrel muscle because of an upregulation of androgen receptors (ARs). Using Western blot analysis, we found that Arctic ground squirrels have AR in skeletal muscle more than four times that of Columbian ground squirrels, a related southern species that overwinters at approximately 0°C and has low pre-hibernation androgen levels. By contrast, AR in lymph nodes was equivalent in both species. Brain AR was also modestly but significantly increased in Arctic ground squirrel relative to Columbian ground squirrel. These results are consistent with the hypothesis that tissue-specific AR regulation prior to hibernation provides a mechanism whereby Arctic ground squirrels obtain the life-history benefits and mitigate the costs associated with high androgen production. AR.ags.cgs.trapping datatrapping data of the animals contributing contributing to the researchmonks.AR.Master.dataAndrogen receptor analysis that is the basis of the paper from the squirrels used |
format |
Dataset |
author |
Boonstra, Rudy Mo, Kaiguo Monks, Douglas Ashley Mo, K. Monks, D. A. Boonstra, R. |
author_facet |
Boonstra, Rudy Mo, Kaiguo Monks, Douglas Ashley Mo, K. Monks, D. A. Boonstra, R. |
author_sort |
Boonstra, Rudy |
title |
Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
title_short |
Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
title_full |
Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
title_fullStr |
Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
title_full_unstemmed |
Data from: Managing anabolic steroids in pre-hibernating Arctic ground squirrels: obtaining their benefits and avoiding their costs |
title_sort |
data from: managing anabolic steroids in pre-hibernating arctic ground squirrels: obtaining their benefits and avoiding their costs |
publishDate |
2020 |
url |
https://doi.org/10.5061/dryad.mt35d |
geographic |
Arctic Yukon |
geographic_facet |
Arctic Yukon |
genre |
Arctic ground squirrel Arctic Urocitellus parryii Yukon |
genre_facet |
Arctic ground squirrel Arctic Urocitellus parryii Yukon |
op_source |
oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:87240 10.5061/dryad.mt35d oai:easy.dans.knaw.nl:easy-dataset:87240 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 |
op_relation |
http://dx.doi.org/10.5061/dryad.mt35d https://dx.doi.org/10.5061/dryad.mt35d |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.mt35d |
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1766305096228929536 |