Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund
Genetic rescue, outcrossing with individuals from a related population, is used to augment genetic diversity in populations threatened by severe inbreeding and extinction. The endangered Norwegian Lundehund dog (henceforth Lundehund) underwent at least two severe bottlenecks in the 1940s and 1960s t...
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2017
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Online Access: | https://doi.org/10.5061/dryad.5gm12 |
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fttriple:oai:gotriple.eu:50|dedup_wf_001::012107df438a8019a590cec8981548fd 2023-05-15T15:51:05+02:00 Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund Stronen, Astrid V Salmela, E Baldursdóttir, BK Berg, P Espelien, IS Järvi, K Jensen, H Kristensen, TN Melis, C Manenti, T Lohi, H Pertoldi, C Salmela, Elina Jensen, Henrik Melis, Claudia Stronen, Astrid V. Kristensen, Torsten N. Pertoldi, Cino Järvi, Kirsi Lohi, Hannes Manenti, Tommaso 2017-06-06 https://doi.org/10.5061/dryad.5gm12 undefined unknown Dryad https://dx.doi.org/10.5061/dryad.5gm12 http://dx.doi.org/10.5061/dryad.5gm12 lic_creative-commons 10.5061/dryad.5gm12 oai:easy.dans.knaw.nl:easy-dataset:101607 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:101607 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 outlier loci Canis lupus familiaris single nucleotide polymorphism Inbreeding dog Life sciences medicine and health care envir hist Dataset https://vocabularies.coar-repositories.org/resource_types/c_ddb1/ 2017 fttriple https://doi.org/10.5061/dryad.5gm12 2023-01-22T16:52:56Z Genetic rescue, outcrossing with individuals from a related population, is used to augment genetic diversity in populations threatened by severe inbreeding and extinction. The endangered Norwegian Lundehund dog (henceforth Lundehund) underwent at least two severe bottlenecks in the 1940s and 1960s that each left only five inbred dogs, and the approximately 1500 dogs remaining world-wide today appear to descend from only two individuals. The Lundehund has a high prevalence of a gastrointestinal disease, to which all remaining dogs may be predisposed. Outcrossing is currently performed with three Nordic Spitz breeds: Norwegian Buhund, Icelandic Sheepdog, and Norrbottenspets. Examination of single nucleotide polymorphism (SNP) genotypes based on 165K loci in 48 dogs from the four breeds revealed substantially lower genetic diversity for the Lundehund (HE 0.035) than for other breeds (HE 0.209-0.284). Analyses of genetic structure with 16K linkage disequilibrium-pruned SNPs showed four distinct genetic clusters. Pairwise FST values between Lundehund and the candidate breeds were highest for Icelandic Sheepdog, followed by Buhund and Norrbottenspets. We assessed the presence of outlier loci among candidate breeds and examined flanking genome regions (1 megabase) for genes under possible selection to identify potential adaptive differences among breeds; outliers were observed in flanking regions of genes associated with key functions including the immune system, metabolism, cognition and physical development. We suggest crossbreeding with multiple breeds as the best strategy to increase genetic diversity for the Lundehund and reduce the incidence of health problems. For this project, the three candidate breeds were first selected based on phenotypes and then subject to genetic investigation. Because phenotypes are often paramount for domestic breed owners, such a strategy could provide a helpful approach for genetic rescue and restoration of other domestic populations at risk, by ensuring the involvement of owners, ... Dataset Canis lupus Unknown |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
unknown |
topic |
outlier loci Canis lupus familiaris single nucleotide polymorphism Inbreeding dog Life sciences medicine and health care envir hist |
spellingShingle |
outlier loci Canis lupus familiaris single nucleotide polymorphism Inbreeding dog Life sciences medicine and health care envir hist Stronen, Astrid V Salmela, E Baldursdóttir, BK Berg, P Espelien, IS Järvi, K Jensen, H Kristensen, TN Melis, C Manenti, T Lohi, H Pertoldi, C Salmela, Elina Jensen, Henrik Melis, Claudia Stronen, Astrid V. Kristensen, Torsten N. Pertoldi, Cino Järvi, Kirsi Lohi, Hannes Manenti, Tommaso Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
topic_facet |
outlier loci Canis lupus familiaris single nucleotide polymorphism Inbreeding dog Life sciences medicine and health care envir hist |
description |
Genetic rescue, outcrossing with individuals from a related population, is used to augment genetic diversity in populations threatened by severe inbreeding and extinction. The endangered Norwegian Lundehund dog (henceforth Lundehund) underwent at least two severe bottlenecks in the 1940s and 1960s that each left only five inbred dogs, and the approximately 1500 dogs remaining world-wide today appear to descend from only two individuals. The Lundehund has a high prevalence of a gastrointestinal disease, to which all remaining dogs may be predisposed. Outcrossing is currently performed with three Nordic Spitz breeds: Norwegian Buhund, Icelandic Sheepdog, and Norrbottenspets. Examination of single nucleotide polymorphism (SNP) genotypes based on 165K loci in 48 dogs from the four breeds revealed substantially lower genetic diversity for the Lundehund (HE 0.035) than for other breeds (HE 0.209-0.284). Analyses of genetic structure with 16K linkage disequilibrium-pruned SNPs showed four distinct genetic clusters. Pairwise FST values between Lundehund and the candidate breeds were highest for Icelandic Sheepdog, followed by Buhund and Norrbottenspets. We assessed the presence of outlier loci among candidate breeds and examined flanking genome regions (1 megabase) for genes under possible selection to identify potential adaptive differences among breeds; outliers were observed in flanking regions of genes associated with key functions including the immune system, metabolism, cognition and physical development. We suggest crossbreeding with multiple breeds as the best strategy to increase genetic diversity for the Lundehund and reduce the incidence of health problems. For this project, the three candidate breeds were first selected based on phenotypes and then subject to genetic investigation. Because phenotypes are often paramount for domestic breed owners, such a strategy could provide a helpful approach for genetic rescue and restoration of other domestic populations at risk, by ensuring the involvement of owners, ... |
format |
Dataset |
author |
Stronen, Astrid V Salmela, E Baldursdóttir, BK Berg, P Espelien, IS Järvi, K Jensen, H Kristensen, TN Melis, C Manenti, T Lohi, H Pertoldi, C Salmela, Elina Jensen, Henrik Melis, Claudia Stronen, Astrid V. Kristensen, Torsten N. Pertoldi, Cino Järvi, Kirsi Lohi, Hannes Manenti, Tommaso |
author_facet |
Stronen, Astrid V Salmela, E Baldursdóttir, BK Berg, P Espelien, IS Järvi, K Jensen, H Kristensen, TN Melis, C Manenti, T Lohi, H Pertoldi, C Salmela, Elina Jensen, Henrik Melis, Claudia Stronen, Astrid V. Kristensen, Torsten N. Pertoldi, Cino Järvi, Kirsi Lohi, Hannes Manenti, Tommaso |
author_sort |
Stronen, Astrid V |
title |
Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
title_short |
Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
title_full |
Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
title_fullStr |
Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
title_full_unstemmed |
Data from: Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the Norwegian Lundehund |
title_sort |
data from: genetic rescue of an endangered domestic animal through outcrossing with closely related breeds: a case study of the norwegian lundehund |
publisher |
Dryad |
publishDate |
2017 |
url |
https://doi.org/10.5061/dryad.5gm12 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
10.5061/dryad.5gm12 oai:easy.dans.knaw.nl:easy-dataset:101607 oai:services.nod.dans.knaw.nl:Products/dans:oai:easy.dans.knaw.nl:easy-dataset:101607 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 re3data_____::r3d100000044 10|re3data_____::84e123776089ce3c7a33db98d9cd15a8 10|re3data_____::94816e6421eeb072e7742ce6a9decc5f 10|eurocrisdris::fe4903425d9040f680d8610d9079ea14 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 |
op_relation |
https://dx.doi.org/10.5061/dryad.5gm12 http://dx.doi.org/10.5061/dryad.5gm12 |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5061/dryad.5gm12 |
_version_ |
1766386139851128832 |