Biochemical and molecular characterization of an original master sex determining gene in salmonids
Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, amon...
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fttriple:oai:gotriple.eu:10670/1.pmrm0x 2023-05-15T15:33:01+02:00 Biochemical and molecular characterization of an original master sex determining gene in salmonids Caractérisation biochimique et moléculaire du déterminant du sexe chez les salmonidés Bertho, Sylvain Rennes, Agrocampus Ouest Universitätsbibliothek (Wurtzbourg, Allemagne) Schartl, Manfred Guiguen, Yann 2016-06-23 http://www.theses.fr/2016NSARB279/document en eng 10670/1.pmrm0x http://www.theses.fr/2016NSARB279/document other Theses.fr Développement du sexe Voies de détermination du sexe SdY Foxl2 Salmonidés Sex development Sex determination pathways Salmonids archeo envir Thesis https://vocabularies.coar-repositories.org/resource_types/c_46ec/ 2016 fttriple 2023-01-22T16:37:09Z Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, among the known sex determining genes, three gene families namely sox, dmrt and TGF-ß factors govern this developmental program. As exception to this rule, sdY “sexually dimorphic on the Y” does not belong to one of these families as it comes from the duplication / evolution of an ancestor gene related to immunity, i.e., the interferon related factor 9, irf9.sdY is the master sex determining gene in salmonids, a group of fishes that include species such as rainbow trout and Atlantic salmon. The present study was aimed to firstly characterize the features of SdY protein. Results indicate that SdY is predominantly localized in the cytoplasm, composed of a ß-sandwich core surrounded by three a-helices as well specific characteristics conferring a putative protein-protein interaction site. Secondly, the study was aimed to understand how SdY could trigger testicular differentiation. Altogether results propose that SdY would trigger testicular differentiation in salmonids by interacting with a prominent female factor. Le développement du sexe est un processus fondamental et versatile qui forme la morphologie, la physiologie et le comportement des animaux. Le processus de développement sous-jacent est composé de la détermination et de la différentiation du sexe. Les mécanismes de détermination du sexe sont souvent génétiques et nommés gènes de détermination du sexe. A l’heure actuelle, parmi les gènes de détermination connus, trois familles de gènes nommément sox, dmrt and les facteurs TGF-ß gouvernent ce processus de développement.Comme exception à cette règle, sdY « sexually dimorphic on the Y » n’appartient à aucune de ces familles puisqu’il provient d’une duplication/évolution d’un gène ancestral de l’immunité, ... Thesis Atlantic salmon Unknown The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
English |
topic |
Développement du sexe Voies de détermination du sexe SdY Foxl2 Salmonidés Sex development Sex determination pathways Salmonids archeo envir |
spellingShingle |
Développement du sexe Voies de détermination du sexe SdY Foxl2 Salmonidés Sex development Sex determination pathways Salmonids archeo envir Bertho, Sylvain Biochemical and molecular characterization of an original master sex determining gene in salmonids |
topic_facet |
Développement du sexe Voies de détermination du sexe SdY Foxl2 Salmonidés Sex development Sex determination pathways Salmonids archeo envir |
description |
Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, among the known sex determining genes, three gene families namely sox, dmrt and TGF-ß factors govern this developmental program. As exception to this rule, sdY “sexually dimorphic on the Y” does not belong to one of these families as it comes from the duplication / evolution of an ancestor gene related to immunity, i.e., the interferon related factor 9, irf9.sdY is the master sex determining gene in salmonids, a group of fishes that include species such as rainbow trout and Atlantic salmon. The present study was aimed to firstly characterize the features of SdY protein. Results indicate that SdY is predominantly localized in the cytoplasm, composed of a ß-sandwich core surrounded by three a-helices as well specific characteristics conferring a putative protein-protein interaction site. Secondly, the study was aimed to understand how SdY could trigger testicular differentiation. Altogether results propose that SdY would trigger testicular differentiation in salmonids by interacting with a prominent female factor. Le développement du sexe est un processus fondamental et versatile qui forme la morphologie, la physiologie et le comportement des animaux. Le processus de développement sous-jacent est composé de la détermination et de la différentiation du sexe. Les mécanismes de détermination du sexe sont souvent génétiques et nommés gènes de détermination du sexe. A l’heure actuelle, parmi les gènes de détermination connus, trois familles de gènes nommément sox, dmrt and les facteurs TGF-ß gouvernent ce processus de développement.Comme exception à cette règle, sdY « sexually dimorphic on the Y » n’appartient à aucune de ces familles puisqu’il provient d’une duplication/évolution d’un gène ancestral de l’immunité, ... |
author2 |
Rennes, Agrocampus Ouest Universitätsbibliothek (Wurtzbourg, Allemagne) Schartl, Manfred Guiguen, Yann |
format |
Thesis |
author |
Bertho, Sylvain |
author_facet |
Bertho, Sylvain |
author_sort |
Bertho, Sylvain |
title |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_short |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_full |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_fullStr |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_full_unstemmed |
Biochemical and molecular characterization of an original master sex determining gene in salmonids |
title_sort |
biochemical and molecular characterization of an original master sex determining gene in salmonids |
publishDate |
2016 |
url |
http://www.theses.fr/2016NSARB279/document |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
The ''Y'' |
geographic_facet |
The ''Y'' |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Theses.fr |
op_relation |
10670/1.pmrm0x http://www.theses.fr/2016NSARB279/document |
op_rights |
other |
_version_ |
1766363493341069312 |