Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird
International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentr...
Published in: | Environmental Toxicology and Chemistry |
---|---|
Main Authors: | , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1002/etc.4978 https://hal.archives-ouvertes.fr/hal-03138452 |
id |
fttriple:oai:gotriple.eu:10670/1.4em0mx |
---|---|
record_format |
openpolar |
spelling |
fttriple:oai:gotriple.eu:10670/1.4em0mx 2023-05-15T15:00:47+02:00 Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) 2021-01-01 https://doi.org/10.1002/etc.4978 https://hal.archives-ouvertes.fr/hal-03138452 en eng HAL CCSD Wiley hal-03138452 doi:10.1002/etc.4978 10670/1.4em0mx https://hal.archives-ouvertes.fr/hal-03138452 undefined Hyper Article en Ligne - Sciences de l'Homme et de la Société ISSN: 0730-7268 EISSN: 1552-8618 Environmental Toxicology and Chemistry Environmental Toxicology and Chemistry, Wiley, In press, ⟨10.1002/etc.4978⟩ Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones envir psy Journal Article https://vocabularies.coar-repositories.org/resource_types/c_6501/ 2021 fttriple https://doi.org/10.1002/etc.4978 2023-01-22T18:36:06Z International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role—controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black‐legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C9‐C14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C11‐ and C13‐PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C10‐PFCA, and TT4 in males, whereas in females C12‐14‐PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex‐dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1–12. © 2020 The Authors. Environmental Toxicology and Chemistry ... Article in Journal/Newspaper Arctic Black-legged Kittiwake rissa tridactyla Svalbard Unknown Arctic Norway Svalbard Environmental Toxicology and Chemistry 40 3 820 831 |
institution |
Open Polar |
collection |
Unknown |
op_collection_id |
fttriple |
language |
English |
topic |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones envir psy |
spellingShingle |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones envir psy Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
topic_facet |
Avian toxicity Ecotoxicology Endocrine‐disrupting compounds Per‐ and polyfluoroalkyl substance Thyroid hormones envir psy |
description |
International audience Per‐ and polyfluoroalkyl substances (PFAS) are associated with several disrupted physiological and endocrine parameters. Regarding endocrine mechanisms, laboratory studies suggest that PFAS could disrupt the thyroid hormone system and alter circulating thyroid hormone concentrations. Thyroid hormones play a ubiquitous role—controlling thermoregulation, metabolism, and reproduction. However, evidence for disruption of thyroid hormones by PFAS remains scarce in wildlife. The present study investigated the associations between concentrations of PFAS, thyroid hormones, and body condition in an arctic seabird, the black‐legged kittiwake (Rissa tridactyla). We collected blood from kittiwakes sampled in Svalbard, Norway (2013 and 2014). Plasma samples were analyzed for total thyroxine (TT4) and total triiodothyronine (TT3) concentrations; detected PFAS included branched and linear (lin) C8 perfluoroalkyl sulfonates (i.e., perfluoroctane sulfonate [PFOS]) and C9‐C14 perfluoroalkyl carboxylates (PFCAs). The dominant PFAS in the kittiwakes were linPFOS and C11‐ and C13‐PFCAs. Generally, male kittiwakes had higher concentrations of PFAS than females. We observed positive correlations between linPFOS, C10‐PFCA, and TT4 in males, whereas in females C12‐14‐PFCAs were positively correlated to TT3. Interestingly, we observed contrasted correlations between PFAS and body condition; the direction of the relationship was sex‐dependent. Although these results show relationships between PFAS and circulating thyroid hormone concentrations in kittiwakes, the study design does not allow for concluding on causal relationships related to effects of PFAS on the thyroid hormone system. Future experimental research is required to quantify this impact of PFAS on the biology of kittiwakes. The apparently different associations among PFAS and body condition for males and females are puzzling, and more research is required. Environ Toxicol Chem 2021;00:1–12. © 2020 The Authors. Environmental Toxicology and Chemistry ... |
author2 |
Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
format |
Article in Journal/Newspaper |
author |
Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing |
author_facet |
Ask, Amalie Vigdel Jenssen, Bjørn Munro Tartu, Sabrina Angelier, Frédéric Chastel, Olivier Gabrielsen, Geir Wing |
author_sort |
Ask, Amalie Vigdel |
title |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_short |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_full |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_fullStr |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_full_unstemmed |
Per‐ and Polyfluoroalkyl Substances Are Positively Associated with Thyroid Hormones in an Arctic Seabird |
title_sort |
per‐ and polyfluoroalkyl substances are positively associated with thyroid hormones in an arctic seabird |
publisher |
HAL CCSD |
publishDate |
2021 |
url |
https://doi.org/10.1002/etc.4978 https://hal.archives-ouvertes.fr/hal-03138452 |
geographic |
Arctic Norway Svalbard |
geographic_facet |
Arctic Norway Svalbard |
genre |
Arctic Black-legged Kittiwake rissa tridactyla Svalbard |
genre_facet |
Arctic Black-legged Kittiwake rissa tridactyla Svalbard |
op_source |
Hyper Article en Ligne - Sciences de l'Homme et de la Société ISSN: 0730-7268 EISSN: 1552-8618 Environmental Toxicology and Chemistry Environmental Toxicology and Chemistry, Wiley, In press, ⟨10.1002/etc.4978⟩ |
op_relation |
hal-03138452 doi:10.1002/etc.4978 10670/1.4em0mx https://hal.archives-ouvertes.fr/hal-03138452 |
op_rights |
undefined |
op_doi |
https://doi.org/10.1002/etc.4978 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
40 |
container_issue |
3 |
container_start_page |
820 |
op_container_end_page |
831 |
_version_ |
1766332844268847104 |