Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth a...
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fttriple:oai:gotriple.eu:10670/1.0eke4k 2023-05-15T13:31:59+02:00 Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections Selan, Laura 2016-01-01 https://doi.org/10.5772/62908 https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd en eng IntechOpen ISBN:9789535124351 doi:10.5772/62908 10670/1.0eke4k https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd lic_creative-commons Open Research Library envir geo Book https://vocabularies.coar-repositories.org/resource_types/c_2f33/ 2016 fttriple https://doi.org/10.5772/62908 2023-01-22T16:33:06Z Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. Book Antarc* Antarctic Unknown Antarctic |
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envir geo Selan, Laura Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
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description |
Biofilm infections represent a new medical challenge that drives towards the discovery of new diagnostics and new drugs specifically designed for this purpose. All living organisms offer a huge source of compounds which represent the biochemical substrate of the biological competition on the Earth and can be used to this aim. We describe an innovative diagnostic tool to early diagnose medical device infections sustained by Staphylococci; then we list new compounds that modulate bacterial phenotype and reduce virulence without affecting bacterial viability so as to avoid the emergence of genetic resistances. These compounds are all derived from natural sources: prokaryotes, plants, and human body. From prokaryotes we studied new compounds extracted from different environmental bacterial species, including Antarctic species growing in extreme environments. We describe also the anti-biofilm properties of extracts obtained from plants well known since centuries in folk medicine. The humoral immune response is the source of the last anti-biofilm compound: transferrin (Tf), a protein derived from human plasma involved in inflammation and natural immunity. All these compounds can be used as scaffolds for the design of new drugs active on the sessile form of pathogens prevalent in human biofilm infections. |
format |
Book |
author |
Selan, Laura |
author_facet |
Selan, Laura |
author_sort |
Selan, Laura |
title |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_short |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_full |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_fullStr |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_full_unstemmed |
Compounds from Natural Sources for New Diagnostics and Drugs against Biofilm Infections |
title_sort |
compounds from natural sources for new diagnostics and drugs against biofilm infections |
publisher |
IntechOpen |
publishDate |
2016 |
url |
https://doi.org/10.5772/62908 https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Open Research Library |
op_relation |
ISBN:9789535124351 doi:10.5772/62908 10670/1.0eke4k https://openresearchlibrary.org/ext/api/media/cc41310d-307c-4bd5-9604-21beb31ac6fd/assets/external_content.pdf https://openresearchlibrary.org/viewer/cc41310d-307c-4bd5-9604-21beb31ac6fd |
op_rights |
lic_creative-commons |
op_doi |
https://doi.org/10.5772/62908 |
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1766023406284701696 |