Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine
Abstract Bioaccumulation of endocrine disruptors in marine mammals positioned at the top of the food chain is of toxicological concern. Stranded four pup and ten adult harbor seal (Phoca vitulina) livers were collected from San Francisco Bay and the Gulf of Maine and analyzed for polychlorinated bip...
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Online Access: | http://hdl.handle.net/2262/50275 https://doi.org/10.1016/j.marenvres.2008.12.003 |
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fttrinitycoll:oai:tara.tcd.ie:2262/50275 2023-05-15T15:41:56+02:00 Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine 2011-02-04T04:40:36Z http://hdl.handle.net/2262/50275 https://doi.org/10.1016/j.marenvres.2008.12.003 en eng Elsevier 01411136 (ISSN) S0141-1136(08)00251-1 (PII) S0141-1136(08)00251-1 (publisherID) http://hdl.handle.net/2262/50275 Marine Environmental Research 67 3 129 doi:10.1016/j.marenvres.2008.12.003 2008 12 months Hydroxylated PCB metabolites Polychlorinated biphenyls Harbor seal liver San Francisco Bay Gulf of Maine 2011 fttrinitycoll https://doi.org/10.1016/j.marenvres.2008.12.003 2020-02-16T13:51:08Z Abstract Bioaccumulation of endocrine disruptors in marine mammals positioned at the top of the food chain is of toxicological concern. Stranded four pup and ten adult harbor seal (Phoca vitulina) livers were collected from San Francisco Bay and the Gulf of Maine and analyzed for polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs). We used GC-ECD and GC-NCI/MS to investigate the presence of 28 PCBs and 8 OH-PCB metabolites, respectively. ?28PCB concentrations (di- to octa-CBs) ranged from 1.81 to 35.9 ?g/g lipid with a median of 6.53 for the seal pups and 2.31 to 249 ?g/g lipid with a median of 28.9 for the adult seals. ?8OH-PCB concentrations (penta- to hepta-OH-PCBs) ranged from 0.02 to 0.69 ?g/g lipid with a median of 0.04 for the adult seals, i.e., at much lower concentrations than those for PCBs. Ratios of OH-PCBs to PCBs (0.24% on average) were comparable to those in beluga whale, but were lower than ratios in human livers. The OH-PCB profiles were slightly different between SFB and GOM seal livers although similar PCB congener patterns were observed. Generally, 4-OH-CB107 was found predominantly in seal livers and was the only OH-PCB detectable in most of seal pup livers. This study provides information on OH-PCBs in seals, adding to the scarce exposure data for these chemicals. correspondence: Corresponding author. (Park, June-Soo) jpark@dtsc.ca.gov (Park, June-Soo) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Park, June-Soo) UNITED STATES (Park, June-Soo) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Kalantzi, Olga Ioanna) Department of Biological Sciences, University of Maine - Orono--> , Maine 04469--> - UNITED STATES (Kopec, Dianne) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Petreas, Myrto) UNITED STATES Received: 2007-08-09 Revised: 2008-12-11 Accepted: 2008-12-12 Other/Unknown Material Beluga Beluga whale Beluga* harbor seal Phoca vitulina The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) Marine Environmental Research 67 3 129 135 |
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Open Polar |
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The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) |
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fttrinitycoll |
language |
English |
topic |
Hydroxylated PCB metabolites Polychlorinated biphenyls Harbor seal liver San Francisco Bay Gulf of Maine |
spellingShingle |
Hydroxylated PCB metabolites Polychlorinated biphenyls Harbor seal liver San Francisco Bay Gulf of Maine Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
topic_facet |
Hydroxylated PCB metabolites Polychlorinated biphenyls Harbor seal liver San Francisco Bay Gulf of Maine |
description |
Abstract Bioaccumulation of endocrine disruptors in marine mammals positioned at the top of the food chain is of toxicological concern. Stranded four pup and ten adult harbor seal (Phoca vitulina) livers were collected from San Francisco Bay and the Gulf of Maine and analyzed for polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs). We used GC-ECD and GC-NCI/MS to investigate the presence of 28 PCBs and 8 OH-PCB metabolites, respectively. ?28PCB concentrations (di- to octa-CBs) ranged from 1.81 to 35.9 ?g/g lipid with a median of 6.53 for the seal pups and 2.31 to 249 ?g/g lipid with a median of 28.9 for the adult seals. ?8OH-PCB concentrations (penta- to hepta-OH-PCBs) ranged from 0.02 to 0.69 ?g/g lipid with a median of 0.04 for the adult seals, i.e., at much lower concentrations than those for PCBs. Ratios of OH-PCBs to PCBs (0.24% on average) were comparable to those in beluga whale, but were lower than ratios in human livers. The OH-PCB profiles were slightly different between SFB and GOM seal livers although similar PCB congener patterns were observed. Generally, 4-OH-CB107 was found predominantly in seal livers and was the only OH-PCB detectable in most of seal pup livers. This study provides information on OH-PCBs in seals, adding to the scarce exposure data for these chemicals. correspondence: Corresponding author. (Park, June-Soo) jpark@dtsc.ca.gov (Park, June-Soo) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Park, June-Soo) UNITED STATES (Park, June-Soo) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Kalantzi, Olga Ioanna) Department of Biological Sciences, University of Maine - Orono--> , Maine 04469--> - UNITED STATES (Kopec, Dianne) Department of Toxic Substances Control, California Environmental Protection Agency - Berkeley--> , California 94710--> - UNITED STATES (Petreas, Myrto) UNITED STATES Received: 2007-08-09 Revised: 2008-12-11 Accepted: 2008-12-12 |
title |
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
title_short |
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
title_full |
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
title_fullStr |
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
title_full_unstemmed |
Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) in harbor seal (Phoca vitulina) livers from San Francisco Bay, California and Gulf of Maine |
title_sort |
polychlorinated biphenyls (pcbs) and their hydroxylated metabolites (oh-pcbs) in harbor seal (phoca vitulina) livers from san francisco bay, california and gulf of maine |
publisher |
Elsevier |
publishDate |
2011 |
url |
http://hdl.handle.net/2262/50275 https://doi.org/10.1016/j.marenvres.2008.12.003 |
genre |
Beluga Beluga whale Beluga* harbor seal Phoca vitulina |
genre_facet |
Beluga Beluga whale Beluga* harbor seal Phoca vitulina |
op_relation |
01411136 (ISSN) S0141-1136(08)00251-1 (PII) S0141-1136(08)00251-1 (publisherID) http://hdl.handle.net/2262/50275 Marine Environmental Research 67 3 129 doi:10.1016/j.marenvres.2008.12.003 |
op_rights |
2008 12 months |
op_doi |
https://doi.org/10.1016/j.marenvres.2008.12.003 |
container_title |
Marine Environmental Research |
container_volume |
67 |
container_issue |
3 |
container_start_page |
129 |
op_container_end_page |
135 |
_version_ |
1766374818824847360 |