Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines

Abstract We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ruiz-Pesini, Mis...

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Published in:Biochemical Journal
Language:English
Published: Portland Press Limited 2010
Subjects:
Life Sciences
Arctic
Online Access:http://hdl.handle.net/2262/44934
https://doi.org/10.1042/BJ20061609
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spelling fttrinitycoll:oai:tara.tcd.ie:2262/44934 2023-05-15T15:03:04+02:00 Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines 2010-12-14T23:03:00Z http://hdl.handle.net/2262/44934 https://doi.org/10.1042/BJ20061609 en eng Portland Press Limited 0264-6021 (ISSN) BJ20061609 (PII) http://hdl.handle.net/2262/44934 Biochemical Journal 404 2 345 351 doi:10.1042/BJ20061609 Open Access Life Sciences 2010 fttrinitycoll https://doi.org/10.1042/BJ20061609 2020-02-16T13:50:01Z Abstract We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mitochondrial DNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. martin.brand@mrc-dunn.cam.ac.uk (Brand, Martin D) MRC Dunn Human Nutrition Unit - UNITED KINGDOM (Brand, Martin D) UNITED KINGDOM Other/Unknown Material Arctic The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) Arctic Biochemical Journal 404 2 345 351
institution Open Polar
collection The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive)
op_collection_id fttrinitycoll
language English
topic Life Sciences
spellingShingle Life Sciences
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
topic_facet Life Sciences
description Abstract We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mitochondrial DNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. martin.brand@mrc-dunn.cam.ac.uk (Brand, Martin D) MRC Dunn Human Nutrition Unit - UNITED KINGDOM (Brand, Martin D) UNITED KINGDOM
title Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_short Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_full Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_fullStr Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_full_unstemmed Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
title_sort were inefficient mitochondrial haplogroups selected during migrations of modern humans? a test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
publisher Portland Press Limited
publishDate 2010
url http://hdl.handle.net/2262/44934
https://doi.org/10.1042/BJ20061609
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_relation 0264-6021 (ISSN)
BJ20061609 (PII)
http://hdl.handle.net/2262/44934
Biochemical Journal
404
2
345
351
doi:10.1042/BJ20061609
op_rights Open Access
op_doi https://doi.org/10.1042/BJ20061609
container_title Biochemical Journal
container_volume 404
container_issue 2
container_start_page 345
op_container_end_page 351
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