Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer
Abstract Germ-line mutations in the tumour suppressor proteins BRCA1 and BRCA2 predispose to breast and ovarian cancer. We have recently identified a Greenlandic Inuit BRCA1 nucleotide 234T>G/c.115T>G (p.Cys39Gly) founder mutation, which at that time was the only disease-causing BRCA1/BRCA2 mu...
| Published in: | Breast Cancer Research and Treatment |
|---|---|
| Language: | English |
| Published: |
Springer US
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/2262/42410 https://doi.org/10.1007/s10549-010-0909-9 |