IGF-I during primiparous pregnancy and maternal risk of breast cancer
Abstract Previously, we reported that insulin-like growth factor (IGF)-I during early pregnancy is positively associated with maternal risk of breast cancer. To further explore this association, we designed a new study limited to women who donated a blood sample during their first pregnancy ending w...
Published in: | Breast Cancer Research and Treatment |
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Language: | English |
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Springer US
2010
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Subjects: | |
Online Access: | http://hdl.handle.net/2262/42319 https://doi.org/10.1007/s10549-009-0519-6 |
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fttrinitycoll:oai:tara.tcd.ie:2262/42319 |
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Open Polar |
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The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) |
op_collection_id |
fttrinitycoll |
language |
English |
topic |
Insulin-like growth factor (IGF)-I Breast cancer Pregnancy Nested case?control study |
spellingShingle |
Insulin-like growth factor (IGF)-I Breast cancer Pregnancy Nested case?control study IGF-I during primiparous pregnancy and maternal risk of breast cancer |
topic_facet |
Insulin-like growth factor (IGF)-I Breast cancer Pregnancy Nested case?control study |
description |
Abstract Previously, we reported that insulin-like growth factor (IGF)-I during early pregnancy is positively associated with maternal risk of breast cancer. To further explore this association, we designed a new study limited to women who donated a blood sample during their first pregnancy ending with childbirth. A case?control study was nested within the Northern Sweden Maternity Cohort in which repository since 1975, serum specimens remaining after early pregnancy screening for infectious diseases had been preserved. Study subjects were selected among women who donated a blood sample during the full-term pregnancy that led to the birth of their first child. Two hundred and forty-four women with invasive breast cancer were eligible. Two controls, matching the index case for age and date at blood donation were selected (n = 453). IGF-I was measured in serum samples on an Immulite 2000 analyzer. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. A significant positive association of breast cancer with IGF-I was observed, with OR of 1.73 (95% CI: 1.14?2.63) for the top tertile, P < 0.009. Subgroup analyses did not indicate statistical heterogeneity of the association by ages at sampling and diagnosis or by lag time to cancer diagnosis, although somewhat stronger associations with risk were observed in women ?age 25 at index pregnancy and for cases diagnosed within 15 years of blood donation. The results of the study add further evidence for an adverse effect of elevated IGF-I concentrations during early reproductive life on risk of breast cancer. a.lukanova@dkfz.de (Lukanova, Annekatrin) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Chen, Tianhui) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Lukanova, Annekatrin) Department of Obstetrics and Gynecology, New York University School of Medicine - New York - UNITED STATES (Lukanova, Annekatrin) Department of Medical Biosciences, University of Ume? - Ume? - SWEDEN (Grankvist, Kjell) Department of Environmental Medicine, New York University School of Medicine - New York - UNITED STATES (Zeleniuch-Jacquotte, Anne) Department of Clinical Sciences/Obstetrics and Gynecology, University of Ume? - Ume? - SWEDEN (Wulff, Marianne) Department of Radiation Sciences, University of Ume? - Ume? - SWEDEN (Johansson, Robert) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Schock, Helena) Department of Radiation Sciences, University of Ume? - Ume? - SWEDEN (Lenner, Per) Department of Public Health and Clinical Medicine/Nutritional Research, University of Ume? - Ume? - SWEDEN (Hallmans, Goran) Department of Clinical Microbiology, University of Ume? - Ume? - SWEDEN (Wadell, Goran) Department of Obstetrics and Gynecology, New York University School of Medicine - New York - UNITED STATES (Toniolo, Paolo) Department of Environmental Medicine, New York University School of Medicine - New York - UNITED STATES (Toniolo, Paolo) Department of Medical Biosciences, University of Ume? - Ume? - SWEDEN (Lundin, Eva) GERMANY SWEDEN UNITED STATES Registration: 2009-08-13 Received: 2009-07-30 Accepted: 2009-08-13 ePublished: 2009-09-02 |
title |
IGF-I during primiparous pregnancy and maternal risk of breast cancer |
title_short |
IGF-I during primiparous pregnancy and maternal risk of breast cancer |
title_full |
IGF-I during primiparous pregnancy and maternal risk of breast cancer |
title_fullStr |
IGF-I during primiparous pregnancy and maternal risk of breast cancer |
title_full_unstemmed |
IGF-I during primiparous pregnancy and maternal risk of breast cancer |
title_sort |
igf-i during primiparous pregnancy and maternal risk of breast cancer |
publisher |
Springer US |
publishDate |
2010 |
url |
http://hdl.handle.net/2262/42319 https://doi.org/10.1007/s10549-009-0519-6 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
0167-6806 (pISSN) 1573-7217 (eISSN) 10549 (JournalID) s10549-009-0519-6 (publisherID) 519 (ArticleID) http://hdl.handle.net/2262/42319 Breast Cancer Research and Treatment 121 1 169 175 doi:10.1007/s10549-009-0519-6 |
op_rights |
Springer Science+Business Media, LLC., 2009 6 months |
op_doi |
https://doi.org/10.1007/s10549-009-0519-6 |
container_title |
Breast Cancer Research and Treatment |
container_volume |
121 |
container_issue |
1 |
container_start_page |
169 |
op_container_end_page |
175 |
_version_ |
1766148135571161088 |
spelling |
fttrinitycoll:oai:tara.tcd.ie:2262/42319 2023-05-15T17:45:16+02:00 IGF-I during primiparous pregnancy and maternal risk of breast cancer 2010-12-14T16:34:50Z http://hdl.handle.net/2262/42319 https://doi.org/10.1007/s10549-009-0519-6 en eng Springer US Boston http://www.springer-ny.com 0167-6806 (pISSN) 1573-7217 (eISSN) 10549 (JournalID) s10549-009-0519-6 (publisherID) 519 (ArticleID) http://hdl.handle.net/2262/42319 Breast Cancer Research and Treatment 121 1 169 175 doi:10.1007/s10549-009-0519-6 Springer Science+Business Media, LLC., 2009 6 months Insulin-like growth factor (IGF)-I Breast cancer Pregnancy Nested case?control study 2010 fttrinitycoll https://doi.org/10.1007/s10549-009-0519-6 2020-02-16T13:49:29Z Abstract Previously, we reported that insulin-like growth factor (IGF)-I during early pregnancy is positively associated with maternal risk of breast cancer. To further explore this association, we designed a new study limited to women who donated a blood sample during their first pregnancy ending with childbirth. A case?control study was nested within the Northern Sweden Maternity Cohort in which repository since 1975, serum specimens remaining after early pregnancy screening for infectious diseases had been preserved. Study subjects were selected among women who donated a blood sample during the full-term pregnancy that led to the birth of their first child. Two hundred and forty-four women with invasive breast cancer were eligible. Two controls, matching the index case for age and date at blood donation were selected (n = 453). IGF-I was measured in serum samples on an Immulite 2000 analyzer. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. A significant positive association of breast cancer with IGF-I was observed, with OR of 1.73 (95% CI: 1.14?2.63) for the top tertile, P < 0.009. Subgroup analyses did not indicate statistical heterogeneity of the association by ages at sampling and diagnosis or by lag time to cancer diagnosis, although somewhat stronger associations with risk were observed in women ?age 25 at index pregnancy and for cases diagnosed within 15 years of blood donation. The results of the study add further evidence for an adverse effect of elevated IGF-I concentrations during early reproductive life on risk of breast cancer. a.lukanova@dkfz.de (Lukanova, Annekatrin) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Chen, Tianhui) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Lukanova, Annekatrin) Department of Obstetrics and Gynecology, New York University School of Medicine - New York - UNITED STATES (Lukanova, Annekatrin) Department of Medical Biosciences, University of Ume? - Ume? - SWEDEN (Grankvist, Kjell) Department of Environmental Medicine, New York University School of Medicine - New York - UNITED STATES (Zeleniuch-Jacquotte, Anne) Department of Clinical Sciences/Obstetrics and Gynecology, University of Ume? - Ume? - SWEDEN (Wulff, Marianne) Department of Radiation Sciences, University of Ume? - Ume? - SWEDEN (Johansson, Robert) Division of Cancer Epidemiology, German Cancer Research Center - Neuenheimer Feld 280 - 69120 - Heidelberg - GERMANY (Schock, Helena) Department of Radiation Sciences, University of Ume? - Ume? - SWEDEN (Lenner, Per) Department of Public Health and Clinical Medicine/Nutritional Research, University of Ume? - Ume? - SWEDEN (Hallmans, Goran) Department of Clinical Microbiology, University of Ume? - Ume? - SWEDEN (Wadell, Goran) Department of Obstetrics and Gynecology, New York University School of Medicine - New York - UNITED STATES (Toniolo, Paolo) Department of Environmental Medicine, New York University School of Medicine - New York - UNITED STATES (Toniolo, Paolo) Department of Medical Biosciences, University of Ume? - Ume? - SWEDEN (Lundin, Eva) GERMANY SWEDEN UNITED STATES Registration: 2009-08-13 Received: 2009-07-30 Accepted: 2009-08-13 ePublished: 2009-09-02 Other/Unknown Material Northern Sweden The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) Breast Cancer Research and Treatment 121 1 169 175 |