The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study
Abstract It is hypothesized that insulin resistance and related metabolic factors may influence breast cancer risk, however the epidemiological evidence remains inconclusive. We conducted a case?control study nested in a prospective cohort in Northern Sweden, to clarify the associations of body mass...
Published in: | Breast Cancer Research and Treatment |
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Language: | English |
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2010
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Online Access: | http://hdl.handle.net/2262/42233 https://doi.org/10.1007/s10549-008-9958-8 |
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fttrinitycoll:oai:tara.tcd.ie:2262/42233 2023-05-15T17:45:15+02:00 The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study 2010-12-14T16:25:02Z http://hdl.handle.net/2262/42233 https://doi.org/10.1007/s10549-008-9958-8 en eng Springer US Boston http://www.springer-ny.com 0167-6806 (pISSN) 1573-7217 (eISSN) 10549 (JournalID) s10549-008-9958-8 (publisherID) 9958 (ArticleID) http://hdl.handle.net/2262/42233 Breast Cancer Research and Treatment 113 3 567 576 doi:10.1007/s10549-008-9958-8 Springer Science+Business Media, LLC., 2008 12 months Adiponectin Breast cancer C-peptide Glycated haemoglobin Leptin Obesity Overweight 2010 fttrinitycoll https://doi.org/10.1007/s10549-008-9958-8 2020-02-16T13:49:29Z Abstract It is hypothesized that insulin resistance and related metabolic factors may influence breast cancer risk, however the epidemiological evidence remains inconclusive. We conducted a case?control study nested in a prospective cohort in Northern Sweden, to clarify the associations of body mass index (BMI), leptin, adiponectin, C-peptide, and glycated haemoglobin (HbA1c) with breast cancer risk. We also investigated whether these associations may be modified by age at diagnosis, tumour stage, and oestrogen and progesterone receptor status. During follow-up, 561 women developed invasive breast cancer and 561 matched controls were selected. Conditional logistic regression was used to calculate odds ratios (OR) as estimates of relative risk, and 95% confidence intervals (CI). The associations of BMI, leptin and HbA1c with breast cancer risk differed significantly according to whether the tumour was diagnosed as stage I or stage II?IV (P heterogeneity all <0.05). These factors were significantly inversely associated with risk in the group of stage I tumours, with ORs for top vs. bottom tertile for BMI of 0.48 (95% CI, 0.30?0.78, P trend = 0.004); leptin, 0.64 (95% CI, 0.41?1.00, P trend = 0.06); and HbA1c, 0.47 (95% CI, 0.28?0.80, P trend = 0.005). For stage II?IV tumours, there was a suggestion of an increased risk with higher levels of these factors. There were no significant differences in the associations of BMI, leptin, adiponectin, C-peptide and HbA1c with breast cancer risk in subgroups of age at diagnosis or tumour receptor status. This prospective study suggests that BMI, leptin and HbA1c influence breast tumour initiation and progression. phone: +46-90-7852984 (Stocks, Tanja) tanja.stocks@urologi.umu.se (Stocks, Tanja) Centre for MEGA Epidemiology, The University of Melbourne - Melbourne - AUSTRALIA (Cust, Anne E.) School of Public Health, The University of Sydney - Sydney - AUSTRALIA (Cust, Anne E.) Nutrition and Hormones Unit, International Agency for Research on Cancer - Lyon - FRANCE (Cust, Anne E.) Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University - 901 85 - Ume? - SWEDEN (Stocks, Tanja) Division of Cancer Epidemiology, German Cancer Research Center - Heidelberg - GERMANY (Lukanova, Annekatrin) Department of Medical Biosciences, Pathology, Ume? University - Ume? - SWEDEN (Lundin, Eva) Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University - Ume? - SWEDEN (Hallmans, Goran) Division of Cancer Epidemiology, German Cancer Research Center - Heidelberg - GERMANY (Kaaks, Rudolf) Department of Radiation Sciences, Oncology, Ume? University - Ume? - SWEDEN (Jonsson, H?kan) Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University - 901 85 - Ume? - SWEDEN (Stattin, Par) AUSTRALIA FRANCE GERMANY SWEDEN Registration: 2008-02-27 Received: 2008-01-25 Accepted: 2008-02-26 ePublished: 2008-03-11 Other/Unknown Material Northern Sweden The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) Breast Cancer Research and Treatment 113 3 567 576 |
institution |
Open Polar |
collection |
The University of Dublin, Trinity College: TARA (Trinity's Access to Research Archive) |
op_collection_id |
fttrinitycoll |
language |
English |
topic |
Adiponectin Breast cancer C-peptide Glycated haemoglobin Leptin Obesity Overweight |
spellingShingle |
Adiponectin Breast cancer C-peptide Glycated haemoglobin Leptin Obesity Overweight The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
topic_facet |
Adiponectin Breast cancer C-peptide Glycated haemoglobin Leptin Obesity Overweight |
description |
Abstract It is hypothesized that insulin resistance and related metabolic factors may influence breast cancer risk, however the epidemiological evidence remains inconclusive. We conducted a case?control study nested in a prospective cohort in Northern Sweden, to clarify the associations of body mass index (BMI), leptin, adiponectin, C-peptide, and glycated haemoglobin (HbA1c) with breast cancer risk. We also investigated whether these associations may be modified by age at diagnosis, tumour stage, and oestrogen and progesterone receptor status. During follow-up, 561 women developed invasive breast cancer and 561 matched controls were selected. Conditional logistic regression was used to calculate odds ratios (OR) as estimates of relative risk, and 95% confidence intervals (CI). The associations of BMI, leptin and HbA1c with breast cancer risk differed significantly according to whether the tumour was diagnosed as stage I or stage II?IV (P heterogeneity all <0.05). These factors were significantly inversely associated with risk in the group of stage I tumours, with ORs for top vs. bottom tertile for BMI of 0.48 (95% CI, 0.30?0.78, P trend = 0.004); leptin, 0.64 (95% CI, 0.41?1.00, P trend = 0.06); and HbA1c, 0.47 (95% CI, 0.28?0.80, P trend = 0.005). For stage II?IV tumours, there was a suggestion of an increased risk with higher levels of these factors. There were no significant differences in the associations of BMI, leptin, adiponectin, C-peptide and HbA1c with breast cancer risk in subgroups of age at diagnosis or tumour receptor status. This prospective study suggests that BMI, leptin and HbA1c influence breast tumour initiation and progression. phone: +46-90-7852984 (Stocks, Tanja) tanja.stocks@urologi.umu.se (Stocks, Tanja) Centre for MEGA Epidemiology, The University of Melbourne - Melbourne - AUSTRALIA (Cust, Anne E.) School of Public Health, The University of Sydney - Sydney - AUSTRALIA (Cust, Anne E.) Nutrition and Hormones Unit, International Agency for Research on Cancer - Lyon - FRANCE (Cust, Anne E.) Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University - 901 85 - Ume? - SWEDEN (Stocks, Tanja) Division of Cancer Epidemiology, German Cancer Research Center - Heidelberg - GERMANY (Lukanova, Annekatrin) Department of Medical Biosciences, Pathology, Ume? University - Ume? - SWEDEN (Lundin, Eva) Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University - Ume? - SWEDEN (Hallmans, Goran) Division of Cancer Epidemiology, German Cancer Research Center - Heidelberg - GERMANY (Kaaks, Rudolf) Department of Radiation Sciences, Oncology, Ume? University - Ume? - SWEDEN (Jonsson, H?kan) Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University - 901 85 - Ume? - SWEDEN (Stattin, Par) AUSTRALIA FRANCE GERMANY SWEDEN Registration: 2008-02-27 Received: 2008-01-25 Accepted: 2008-02-26 ePublished: 2008-03-11 |
title |
The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
title_short |
The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
title_full |
The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
title_fullStr |
The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
title_full_unstemmed |
The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
title_sort |
influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study |
publisher |
Springer US |
publishDate |
2010 |
url |
http://hdl.handle.net/2262/42233 https://doi.org/10.1007/s10549-008-9958-8 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
0167-6806 (pISSN) 1573-7217 (eISSN) 10549 (JournalID) s10549-008-9958-8 (publisherID) 9958 (ArticleID) http://hdl.handle.net/2262/42233 Breast Cancer Research and Treatment 113 3 567 576 doi:10.1007/s10549-008-9958-8 |
op_rights |
Springer Science+Business Media, LLC., 2008 12 months |
op_doi |
https://doi.org/10.1007/s10549-008-9958-8 |
container_title |
Breast Cancer Research and Treatment |
container_volume |
113 |
container_issue |
3 |
container_start_page |
567 |
op_container_end_page |
576 |
_version_ |
1766148113878220800 |