Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats:
Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN...
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2007
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fttno:oai:tudelft.nl:uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 2023-05-15T18:05:38+02:00 Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: Jonge, J.D. de Ezendam, J. Knippels, L.M.J. Odink, J. Pourier, M.S. Penninks, A.H. Pieters, R. Loveren, H. van 2007-01-01 http://resolver.tudelft.nl/uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 en eng uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 240193 http://resolver.tudelft.nl/uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 Toxicology, 1-2, 239, 68-76 Health Toxicology and Applied Pharmacology Bis(tributyltin)oxide Brown Norway rat Food allergy Ovalbumin Peanut TBTO bis(tributyltin) oxide cytokine immunoglobulin E proteinase animal cell animal experiment animal model article basophil controlled study cytokine production eosinophil female food chain granulocyte immunology immunomodulation lymphocyte proliferation mast cell mesentery lymph node nonhuman peanut allergy Peyer patch priority journal rat risk assessment spleen cell Th2 cell Adjuvants Immunologic Administration Oral Allergens Animals Antibody Formation Cell Count Cell Proliferation Disease Models Animal Granulocytes Immunosuppressive Agents Lymph Nodes Lymphocytes Mast Cells Metalloendopeptidases Peanut Hypersensitivity Peyer's Patches Rats Inbred BN Spleen Trialkyltin Compounds Arachis hypogaea Rattus Rattus norvegicus article 2007 fttno 2022-04-10T15:55:40Z Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN) rats. To study these effects BN rats were sensitized to either 1 or 10 mg peanut or ovalbumin by daily oral gavage and the TBTO-groups were fed a diet containing 80 mg TBTO per kg diet. Co-exposure to TBTO not only resulted in decreased general immunologic parameters such as weights of mesenteric lymph nodes and Peyer's patches, lymphocyte proliferation rates in splenocytes, but also on allergic parameters. In the peanut allergen-model TBTO decreased allergen-specific Th2 cytokine production by spleen cells, number of eosinophilic and basophilic granulocytes in the blood and production of mast cell protease II after oral food challenge. In the ovalbumin allergen-model TBTO decreased the number of eosinophilic and basophilic granulocytes, allergen-specific IgE and production of mast cell protease II after oral food challenge. The data imply that in the process of risk assessment of food allergy attention should be given to immunomodulating compounds present in the diet. © 2007 Elsevier Ireland Ltd. All rights reserved. Article in Journal/Newspaper Rattus rattus TU Delft: Institutional Repository (Delft University of Technology) Norway |
institution |
Open Polar |
collection |
TU Delft: Institutional Repository (Delft University of Technology) |
op_collection_id |
fttno |
language |
English |
topic |
Health Toxicology and Applied Pharmacology Bis(tributyltin)oxide Brown Norway rat Food allergy Ovalbumin Peanut TBTO bis(tributyltin) oxide cytokine immunoglobulin E proteinase animal cell animal experiment animal model article basophil controlled study cytokine production eosinophil female food chain granulocyte immunology immunomodulation lymphocyte proliferation mast cell mesentery lymph node nonhuman peanut allergy Peyer patch priority journal rat risk assessment spleen cell Th2 cell Adjuvants Immunologic Administration Oral Allergens Animals Antibody Formation Cell Count Cell Proliferation Disease Models Animal Granulocytes Immunosuppressive Agents Lymph Nodes Lymphocytes Mast Cells Metalloendopeptidases Peanut Hypersensitivity Peyer's Patches Rats Inbred BN Spleen Trialkyltin Compounds Arachis hypogaea Rattus Rattus norvegicus |
spellingShingle |
Health Toxicology and Applied Pharmacology Bis(tributyltin)oxide Brown Norway rat Food allergy Ovalbumin Peanut TBTO bis(tributyltin) oxide cytokine immunoglobulin E proteinase animal cell animal experiment animal model article basophil controlled study cytokine production eosinophil female food chain granulocyte immunology immunomodulation lymphocyte proliferation mast cell mesentery lymph node nonhuman peanut allergy Peyer patch priority journal rat risk assessment spleen cell Th2 cell Adjuvants Immunologic Administration Oral Allergens Animals Antibody Formation Cell Count Cell Proliferation Disease Models Animal Granulocytes Immunosuppressive Agents Lymph Nodes Lymphocytes Mast Cells Metalloendopeptidases Peanut Hypersensitivity Peyer's Patches Rats Inbred BN Spleen Trialkyltin Compounds Arachis hypogaea Rattus Rattus norvegicus Jonge, J.D. de Ezendam, J. Knippels, L.M.J. Odink, J. Pourier, M.S. Penninks, A.H. Pieters, R. Loveren, H. van Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
topic_facet |
Health Toxicology and Applied Pharmacology Bis(tributyltin)oxide Brown Norway rat Food allergy Ovalbumin Peanut TBTO bis(tributyltin) oxide cytokine immunoglobulin E proteinase animal cell animal experiment animal model article basophil controlled study cytokine production eosinophil female food chain granulocyte immunology immunomodulation lymphocyte proliferation mast cell mesentery lymph node nonhuman peanut allergy Peyer patch priority journal rat risk assessment spleen cell Th2 cell Adjuvants Immunologic Administration Oral Allergens Animals Antibody Formation Cell Count Cell Proliferation Disease Models Animal Granulocytes Immunosuppressive Agents Lymph Nodes Lymphocytes Mast Cells Metalloendopeptidases Peanut Hypersensitivity Peyer's Patches Rats Inbred BN Spleen Trialkyltin Compounds Arachis hypogaea Rattus Rattus norvegicus |
description |
Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food allergy to peanut or ovalbumin in Brown Norway (BN) rats. To study these effects BN rats were sensitized to either 1 or 10 mg peanut or ovalbumin by daily oral gavage and the TBTO-groups were fed a diet containing 80 mg TBTO per kg diet. Co-exposure to TBTO not only resulted in decreased general immunologic parameters such as weights of mesenteric lymph nodes and Peyer's patches, lymphocyte proliferation rates in splenocytes, but also on allergic parameters. In the peanut allergen-model TBTO decreased allergen-specific Th2 cytokine production by spleen cells, number of eosinophilic and basophilic granulocytes in the blood and production of mast cell protease II after oral food challenge. In the ovalbumin allergen-model TBTO decreased the number of eosinophilic and basophilic granulocytes, allergen-specific IgE and production of mast cell protease II after oral food challenge. The data imply that in the process of risk assessment of food allergy attention should be given to immunomodulating compounds present in the diet. © 2007 Elsevier Ireland Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Jonge, J.D. de Ezendam, J. Knippels, L.M.J. Odink, J. Pourier, M.S. Penninks, A.H. Pieters, R. Loveren, H. van |
author_facet |
Jonge, J.D. de Ezendam, J. Knippels, L.M.J. Odink, J. Pourier, M.S. Penninks, A.H. Pieters, R. Loveren, H. van |
author_sort |
Jonge, J.D. de |
title |
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
title_short |
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
title_full |
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
title_fullStr |
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
title_full_unstemmed |
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats: |
title_sort |
bis(tributyltin)oxide (tbto) decreases the food allergic response against peanut and ovalbumin in brown norway rats: |
publishDate |
2007 |
url |
http://resolver.tudelft.nl/uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Toxicology, 1-2, 239, 68-76 |
op_relation |
uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 240193 http://resolver.tudelft.nl/uuid:f5a64d14-9ad0-40a8-8a5e-de358ed40a84 |
_version_ |
1766177119836045312 |