Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age:
The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies,...
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fttno:oai:tudelft.nl:uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 2023-05-15T18:05:42+02:00 Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: Kuper, C.F. Zijverden, M. van Klaassen, C. Tegelenbosch-Schouten, M. Wolterbeek, A.P.M. 2007-01-01 http://resolver.tudelft.nl/uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 en eng uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 239896 http://resolver.tudelft.nl/uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 Toxicologic Pathology, 2, 35, 226-232 Biology Toxicology and Applied Pharmacology Adult exposure Cyclophosphamide Cyclosporin Fetal exposure Peyer's patches Rat cyclosporin A animal experiment animal tissue article controlled study drug effect female fetotoxicity germinal center gestation period immunotoxicity lactation lymphocyte male microscopy newborn period nonhuman Peyer patch pregnancy priority journal small intestine Wistar rat Administration Oral Aging Animals Cell Count Cyclosporine Immunosuppressive Agents Injections Intravenous Prenatal Exposure Delayed Effects Rats Wistar Animalia Rattus Rattus norvegicus article 2007 fttno 2022-04-10T15:47:35Z The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats received orally 5 or 20 mg/kg/day CY or 5 or 10 mg/kg bw CPS for 4 weeks; males received orally 5 mg/kg bw CPS for 4 weeks, or a single iv injection of 50 mg/kg bw CPS. Upon in utero and neonatal exposure, the numbers of grossly observed PP were increased in male pups from the high-dose CY dams at 70 days of age. Exposure to high-dose CY at adult age only tended to decrease the numbers of PP; germinal center development was reduced in the PP from the middle segment of the small intestines, as examined microscopically. Exposure to both doses CPS at adult age reduced the numbers of PP and reduced germinal centre development and the number of lymphocytes in all compartments of PP. It was concluded that the effects of CPS and CY could be established by counting the number of grossly visible PP and by microscopic observation of PP, provided that regional differences of PP were taken into account. Moreover, the type of effects of an immunotoxic agent may vary with age of exposure. Copyright © by the Society of Toxicologic Pathology. Article in Journal/Newspaper Rattus rattus TU Delft: Institutional Repository (Delft University of Technology) |
institution |
Open Polar |
collection |
TU Delft: Institutional Repository (Delft University of Technology) |
op_collection_id |
fttno |
language |
English |
topic |
Biology Toxicology and Applied Pharmacology Adult exposure Cyclophosphamide Cyclosporin Fetal exposure Peyer's patches Rat cyclosporin A animal experiment animal tissue article controlled study drug effect female fetotoxicity germinal center gestation period immunotoxicity lactation lymphocyte male microscopy newborn period nonhuman Peyer patch pregnancy priority journal small intestine Wistar rat Administration Oral Aging Animals Cell Count Cyclosporine Immunosuppressive Agents Injections Intravenous Prenatal Exposure Delayed Effects Rats Wistar Animalia Rattus Rattus norvegicus |
spellingShingle |
Biology Toxicology and Applied Pharmacology Adult exposure Cyclophosphamide Cyclosporin Fetal exposure Peyer's patches Rat cyclosporin A animal experiment animal tissue article controlled study drug effect female fetotoxicity germinal center gestation period immunotoxicity lactation lymphocyte male microscopy newborn period nonhuman Peyer patch pregnancy priority journal small intestine Wistar rat Administration Oral Aging Animals Cell Count Cyclosporine Immunosuppressive Agents Injections Intravenous Prenatal Exposure Delayed Effects Rats Wistar Animalia Rattus Rattus norvegicus Kuper, C.F. Zijverden, M. van Klaassen, C. Tegelenbosch-Schouten, M. Wolterbeek, A.P.M. Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
topic_facet |
Biology Toxicology and Applied Pharmacology Adult exposure Cyclophosphamide Cyclosporin Fetal exposure Peyer's patches Rat cyclosporin A animal experiment animal tissue article controlled study drug effect female fetotoxicity germinal center gestation period immunotoxicity lactation lymphocyte male microscopy newborn period nonhuman Peyer patch pregnancy priority journal small intestine Wistar rat Administration Oral Aging Animals Cell Count Cyclosporine Immunosuppressive Agents Injections Intravenous Prenatal Exposure Delayed Effects Rats Wistar Animalia Rattus Rattus norvegicus |
description |
The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats received orally 5 or 20 mg/kg/day CY or 5 or 10 mg/kg bw CPS for 4 weeks; males received orally 5 mg/kg bw CPS for 4 weeks, or a single iv injection of 50 mg/kg bw CPS. Upon in utero and neonatal exposure, the numbers of grossly observed PP were increased in male pups from the high-dose CY dams at 70 days of age. Exposure to high-dose CY at adult age only tended to decrease the numbers of PP; germinal center development was reduced in the PP from the middle segment of the small intestines, as examined microscopically. Exposure to both doses CPS at adult age reduced the numbers of PP and reduced germinal centre development and the number of lymphocytes in all compartments of PP. It was concluded that the effects of CPS and CY could be established by counting the number of grossly visible PP and by microscopic observation of PP, provided that regional differences of PP were taken into account. Moreover, the type of effects of an immunotoxic agent may vary with age of exposure. Copyright © by the Society of Toxicologic Pathology. |
format |
Article in Journal/Newspaper |
author |
Kuper, C.F. Zijverden, M. van Klaassen, C. Tegelenbosch-Schouten, M. Wolterbeek, A.P.M. |
author_facet |
Kuper, C.F. Zijverden, M. van Klaassen, C. Tegelenbosch-Schouten, M. Wolterbeek, A.P.M. |
author_sort |
Kuper, C.F. |
title |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
title_short |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
title_full |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
title_fullStr |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
title_full_unstemmed |
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age: |
title_sort |
effects of cyclosporin a and cyclophosphamide on peyer's patches in rat, exposed in utero and neonatally or during adult age: |
publishDate |
2007 |
url |
http://resolver.tudelft.nl/uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Toxicologic Pathology, 2, 35, 226-232 |
op_relation |
uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 239896 http://resolver.tudelft.nl/uuid:aa1cc766-4dcb-49a0-bd46-5602655448c6 |
_version_ |
1766177213323935744 |