Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit:
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for th...
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1995
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fttno:oai:tudelft.nl:uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 2023-05-15T16:06:37+02:00 Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: Maat, M.P.M. de Knijff, P. de Green, F.R. Thomas, A.E. Jespersen, J. Kluft, C. 1995-01-01 http://resolver.tudelft.nl/uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 en eng uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 232841 http://resolver.tudelft.nl/uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 Arteriosclerosis, Thrombosis, and Vascular Biology, 7, 15, 856-860 Biology cardiovascular risk DNA polymorphism fibrinogen indicators Inuit acute phase response allele coronary risk disease association female fibrinogen blood level gene linkage disequilibrium gene locus genotype greenland human major clinical study promoter region sex difference Adult Alleles Body Mass Index C-Reactive Protein Deoxyribonucleases Type II Site-Specific Eskimos Linkage Disequilibrium Male Mongoloid Race Polymorphism Restriction Fragment Length Sex Characteristics Smoking article 1995 fttno 2022-04-10T16:28:12Z Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for the Bβ-chain (Bcl I and G/A 455) and the Aα-chain (Taq I) of fibrinogen have higher plasma fibrinogen levels and that patients with peripheral arterial disease have a higher frequency of the rare allele of the Bcl I polymorphism that do healthy control subjects. We studied the Greenland Inuit, a population with a low incidence of ischemic heart disease; polymorphisms of the fibrinogen gene; and their association with plasma fibrinogen level. The group studied had a small age range (30 to 34 years), 97% were smokers, 62 were men, and 71 were women. We observed that in the Inuit, frequencies of the rare alleles of the β gene and of the common alleles of the α gene polymorphisms were lower than those published for other populations (all Caucasian). Accordingly, in the Inuit, these distribution patterns given a higher frequency of alleles that are associated with lower plasma fibrinogen levels. We further observed comparable linkage disequilibrium between α and β gene polymorphisms in Caucasian populations. In Inuit men the rare allele of the Bcl I and G/A 455 fibrinogen polymorphisms was associated with plasma fibrinogen level comparable with the association described in Caucasian populations. In women, however, we did not find a significant association, supporting the desirability of separate data analysis for men and women of the influence of genetic factors on atherosclerotic disease. In conclusion, in the Inuit the association of fibrinogen polymorphisms with fibrinogen levels is comparable with that in Caucasians, but the genes that are associated with lower fibrinogen levels are more frequent in the Inuit than in Caucasians. Article in Journal/Newspaper eskimo* Greenland inuit TU Delft: Institutional Repository (Delft University of Technology) Greenland |
institution |
Open Polar |
collection |
TU Delft: Institutional Repository (Delft University of Technology) |
op_collection_id |
fttno |
language |
English |
topic |
Biology cardiovascular risk DNA polymorphism fibrinogen indicators Inuit acute phase response allele coronary risk disease association female fibrinogen blood level gene linkage disequilibrium gene locus genotype greenland human major clinical study promoter region sex difference Adult Alleles Body Mass Index C-Reactive Protein Deoxyribonucleases Type II Site-Specific Eskimos Linkage Disequilibrium Male Mongoloid Race Polymorphism Restriction Fragment Length Sex Characteristics Smoking |
spellingShingle |
Biology cardiovascular risk DNA polymorphism fibrinogen indicators Inuit acute phase response allele coronary risk disease association female fibrinogen blood level gene linkage disequilibrium gene locus genotype greenland human major clinical study promoter region sex difference Adult Alleles Body Mass Index C-Reactive Protein Deoxyribonucleases Type II Site-Specific Eskimos Linkage Disequilibrium Male Mongoloid Race Polymorphism Restriction Fragment Length Sex Characteristics Smoking Maat, M.P.M. de Knijff, P. de Green, F.R. Thomas, A.E. Jespersen, J. Kluft, C. Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
topic_facet |
Biology cardiovascular risk DNA polymorphism fibrinogen indicators Inuit acute phase response allele coronary risk disease association female fibrinogen blood level gene linkage disequilibrium gene locus genotype greenland human major clinical study promoter region sex difference Adult Alleles Body Mass Index C-Reactive Protein Deoxyribonucleases Type II Site-Specific Eskimos Linkage Disequilibrium Male Mongoloid Race Polymorphism Restriction Fragment Length Sex Characteristics Smoking |
description |
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for the Bβ-chain (Bcl I and G/A 455) and the Aα-chain (Taq I) of fibrinogen have higher plasma fibrinogen levels and that patients with peripheral arterial disease have a higher frequency of the rare allele of the Bcl I polymorphism that do healthy control subjects. We studied the Greenland Inuit, a population with a low incidence of ischemic heart disease; polymorphisms of the fibrinogen gene; and their association with plasma fibrinogen level. The group studied had a small age range (30 to 34 years), 97% were smokers, 62 were men, and 71 were women. We observed that in the Inuit, frequencies of the rare alleles of the β gene and of the common alleles of the α gene polymorphisms were lower than those published for other populations (all Caucasian). Accordingly, in the Inuit, these distribution patterns given a higher frequency of alleles that are associated with lower plasma fibrinogen levels. We further observed comparable linkage disequilibrium between α and β gene polymorphisms in Caucasian populations. In Inuit men the rare allele of the Bcl I and G/A 455 fibrinogen polymorphisms was associated with plasma fibrinogen level comparable with the association described in Caucasian populations. In women, however, we did not find a significant association, supporting the desirability of separate data analysis for men and women of the influence of genetic factors on atherosclerotic disease. In conclusion, in the Inuit the association of fibrinogen polymorphisms with fibrinogen levels is comparable with that in Caucasians, but the genes that are associated with lower fibrinogen levels are more frequent in the Inuit than in Caucasians. |
format |
Article in Journal/Newspaper |
author |
Maat, M.P.M. de Knijff, P. de Green, F.R. Thomas, A.E. Jespersen, J. Kluft, C. |
author_facet |
Maat, M.P.M. de Knijff, P. de Green, F.R. Thomas, A.E. Jespersen, J. Kluft, C. |
author_sort |
Maat, M.P.M. de |
title |
Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
title_short |
Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
title_full |
Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
title_fullStr |
Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
title_full_unstemmed |
Gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in Greenland Inuit: |
title_sort |
gender-related association between β-fibrinogen genotype and plasma fibrinogen levels and linkage disequilibrium at the fibrinogen locus in greenland inuit: |
publishDate |
1995 |
url |
http://resolver.tudelft.nl/uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit |
genre_facet |
eskimo* Greenland inuit |
op_source |
Arteriosclerosis, Thrombosis, and Vascular Biology, 7, 15, 856-860 |
op_relation |
uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 232841 http://resolver.tudelft.nl/uuid:7b1bc59a-38e8-4fc7-995d-070bea04fa38 |
_version_ |
1766402612983234560 |