Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses
Both, oral and intravenous (IV) testing protocols, are recommended and still used to detect insulin dysregulation (ID) in equids. However, IV tests mainly focus on peripheral insulin resistance (IR), while oral tests assess hyperinsulinemia (HI), which are different aspects of ID. The objective of t...
Published in: | The Veterinary Journal |
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Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2023
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Online Access: | https://doi.org/10.1016/j.tvjl.2023.106012 https://elib.tiho-hannover.de/receive/tiho_mods_00010841 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002725/1-s2.0-S1090023323000631-main.pdf https://www.sciencedirect.com/science/article/pii/S1090023323000631? |
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fttihohannover:oai:elib.tiho-hannover.de:tiho_mods_00010841 2024-09-15T18:14:36+00:00 Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses Frers, Florian Delarocque, Julien Huber, K. Feige, Karsten Warnken, Tobias 2023 https://doi.org/10.1016/j.tvjl.2023.106012 https://elib.tiho-hannover.de/receive/tiho_mods_00010841 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002725/1-s2.0-S1090023323000631-main.pdf https://www.sciencedirect.com/science/article/pii/S1090023323000631? eng eng The veterinary journal -- Vet J -- http://www.sciencedirect.com/science/journal/10900233 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2002624 -- 2002624-9 -- 1532-2971 -- 1090-0233 https://doi.org/10.1016/j.tvjl.2023.106012 https://elib.tiho-hannover.de/receive/tiho_mods_00010841 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002725/1-s2.0-S1090023323000631-main.pdf https://www.sciencedirect.com/science/article/pii/S1090023323000631? all rights reserved info:eu-repo/semantics/openAccess article ddc:630 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Animals Swine Horses Insulin Resistance Horse Diseases Swine Diseases Zinc Insulin Glucose Blood Glucose Glucose Tolerance Test Cross-Over Studies Iceland Equine Metabolic Syndrome Oral Glucose Test Insulin Dysregulation Insulin Response Test Porcine Zinc Insulin article Text doc-type:article 2023 fttihohannover https://doi.org/10.1016/j.tvjl.2023.106012 2024-09-05T14:00:10Z Both, oral and intravenous (IV) testing protocols, are recommended and still used to detect insulin dysregulation (ID) in equids. However, IV tests mainly focus on peripheral insulin resistance (IR), while oral tests assess hyperinsulinemia (HI), which are different aspects of ID. The objective of this study was to describe if horses with HI also demonstrate IR and consequently can be detected by a modified 2-step insulin response test (2-step IRT) performed with a veterinary approved porcine zinc insulin (PZI). Twelve Icelandic horses were subjected to an OGT and 2-step IRT in a crossover study. Serum insulin concentrations during the OGT revealed that six horses were hyperinsulinemic (HI) while six were not (NON-HI). To describe the glucose response to IV injected PZI, the decline of plasma glucose concentration within the first 30 min was analyzed. Glucose reduction was similar in horses with and without HI during the 2-step IRT over time. Additionally, none of the horses reached a glucose reduction of ≥ 50% at 30 min. The results of the present study indicated that a comparable insulin mediated glucose uptake may be observed in horses with and without HI during a modified 2-step IRT. While six out of twelve horses were identified as HI by the OGT, all twelve horses were identified as IR by the modified 2-step IRT performed with PZI underlining the importance, but difficulty in choosing the right diagnostic tool in clinical settings to assess ID. Article in Journal/Newspaper Iceland TiHo eLib (University of Veterinary Medicine Hannover) The Veterinary Journal 298-299 106012 |
institution |
Open Polar |
collection |
TiHo eLib (University of Veterinary Medicine Hannover) |
op_collection_id |
fttihohannover |
language |
English |
topic |
article ddc:630 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Animals Swine Horses Insulin Resistance Horse Diseases Swine Diseases Zinc Insulin Glucose Blood Glucose Glucose Tolerance Test Cross-Over Studies Iceland Equine Metabolic Syndrome Oral Glucose Test Insulin Dysregulation Insulin Response Test Porcine Zinc Insulin |
spellingShingle |
article ddc:630 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Animals Swine Horses Insulin Resistance Horse Diseases Swine Diseases Zinc Insulin Glucose Blood Glucose Glucose Tolerance Test Cross-Over Studies Iceland Equine Metabolic Syndrome Oral Glucose Test Insulin Dysregulation Insulin Response Test Porcine Zinc Insulin Frers, Florian Delarocque, Julien Huber, K. Feige, Karsten Warnken, Tobias Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
topic_facet |
article ddc:630 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Animals Swine Horses Insulin Resistance Horse Diseases Swine Diseases Zinc Insulin Glucose Blood Glucose Glucose Tolerance Test Cross-Over Studies Iceland Equine Metabolic Syndrome Oral Glucose Test Insulin Dysregulation Insulin Response Test Porcine Zinc Insulin |
description |
Both, oral and intravenous (IV) testing protocols, are recommended and still used to detect insulin dysregulation (ID) in equids. However, IV tests mainly focus on peripheral insulin resistance (IR), while oral tests assess hyperinsulinemia (HI), which are different aspects of ID. The objective of this study was to describe if horses with HI also demonstrate IR and consequently can be detected by a modified 2-step insulin response test (2-step IRT) performed with a veterinary approved porcine zinc insulin (PZI). Twelve Icelandic horses were subjected to an OGT and 2-step IRT in a crossover study. Serum insulin concentrations during the OGT revealed that six horses were hyperinsulinemic (HI) while six were not (NON-HI). To describe the glucose response to IV injected PZI, the decline of plasma glucose concentration within the first 30 min was analyzed. Glucose reduction was similar in horses with and without HI during the 2-step IRT over time. Additionally, none of the horses reached a glucose reduction of ≥ 50% at 30 min. The results of the present study indicated that a comparable insulin mediated glucose uptake may be observed in horses with and without HI during a modified 2-step IRT. While six out of twelve horses were identified as HI by the OGT, all twelve horses were identified as IR by the modified 2-step IRT performed with PZI underlining the importance, but difficulty in choosing the right diagnostic tool in clinical settings to assess ID. |
format |
Article in Journal/Newspaper |
author |
Frers, Florian Delarocque, Julien Huber, K. Feige, Karsten Warnken, Tobias |
author_facet |
Frers, Florian Delarocque, Julien Huber, K. Feige, Karsten Warnken, Tobias |
author_sort |
Frers, Florian |
title |
Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
title_short |
Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
title_full |
Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
title_fullStr |
Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
title_full_unstemmed |
Comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic Icelandic horses |
title_sort |
comparison of a modified 2-step insulin response test performed with porcine zinc insulin and an oral glucose test to detect hyperinsulinemic icelandic horses |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.tvjl.2023.106012 https://elib.tiho-hannover.de/receive/tiho_mods_00010841 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002725/1-s2.0-S1090023323000631-main.pdf https://www.sciencedirect.com/science/article/pii/S1090023323000631? |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
The veterinary journal -- Vet J -- http://www.sciencedirect.com/science/journal/10900233 -- http://www.bibliothek.uni-regensburg.de/ezeit/?2002624 -- 2002624-9 -- 1532-2971 -- 1090-0233 https://doi.org/10.1016/j.tvjl.2023.106012 https://elib.tiho-hannover.de/receive/tiho_mods_00010841 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002725/1-s2.0-S1090023323000631-main.pdf https://www.sciencedirect.com/science/article/pii/S1090023323000631? |
op_rights |
all rights reserved info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.tvjl.2023.106012 |
container_title |
The Veterinary Journal |
container_volume |
298-299 |
container_start_page |
106012 |
_version_ |
1810452368958947328 |