Gene expression and trace elements in greenlandic ringed seals (Pusa hispida)
Marine top predators such as ringed seals biomagnify environmental contaminants; and with the increasing human activities in the Arctic, ringed seals are exposed to biologically significant concentrations of trace elements resulting in reproductive impairment, immunosuppression, and neurological dam...
Published in: | Environmental Research |
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2023
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fttihohannover:oai:elib.tiho-hannover.de:tiho_mods_00010344 2024-05-19T07:35:52+00:00 Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) Boyi, Joy Ometere Sonne, Christian Dietz, Rune Rigét, Frank Siebert, Ursula Lehnert, Kristina 2023 https://doi.org/10.1016/j.envres.2023.117839 https://elib.tiho-hannover.de/receive/tiho_mods_00010344 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002616/1-s2.0-S0013935123026439-main.pdf https://www.sciencedirect.com/science/article/pii/S0013935123026439?via%3Dihub eng eng Environmental research -- Environ. Res. -- ER -- 1467489-0 -- 0013-9351 -- 1096-0953 -- https://www.sciencedirect.com/journal/environmental-research -- http://ezb.uni-regensburg.de/ezeit/detail.phtml?bibid=TIHO&colors=7&lang=de&jour_id=1579 https://doi.org/10.1016/j.envres.2023.117839 https://elib.tiho-hannover.de/receive/tiho_mods_00010344 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002616/1-s2.0-S0013935123026439-main.pdf https://www.sciencedirect.com/science/article/pii/S0013935123026439?via%3Dihub https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess article ddc:570 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Metals Mercury Cytokines Immune response Biomarkers Endocrine system article Text doc-type:article 2023 fttihohannover https://doi.org/10.1016/j.envres.2023.117839 2024-04-19T02:30:19Z Marine top predators such as ringed seals biomagnify environmental contaminants; and with the increasing human activities in the Arctic, ringed seals are exposed to biologically significant concentrations of trace elements resulting in reproductive impairment, immunosuppression, and neurological damages. Little is known about the molecular effects of heavy metals on these vulnerable apex predators suffering from a rapidly changing Arctic with significant loss of sea-ice. In the present study, concentrations of cadmium (Cd), mercury (Hg) and selenium (Se) were measured in liver of sixteen Greenlandic ringed seals (nine adults and seven subadults) together with molecular biomarkers involved in bio-transformation, oxidative stress, endocrine disruption and immune activity in blood and blubber. The concentrations of trace elements increased in the following order: Hg > Se > Cd with levels of mercury and selenium being highest in adults. Aryl hydrocarbon receptor nuclear translocator (ARNT), peroxisome proliferator activated receptor alpha (PPARα, estrogen receptor alpha (ESR1), thyroid hormone receptor alpha (TRα) and interleukin - 2 (IL-2) mRNA transcript levels were highest in blubber, while heat shock protein 70 (HSP70) and interleukin - 10 (IL-10) were significantly higher in blood. There were no significant correlations between the concentrations of trace elements and mRNA transcript levels suggesting that stressors other than the trace elements investigated are responsible for the changes in gene expression levels. Since Hg seems to increase in Greenlandic ringed seals, there is a need to re-enforce health monitoring of this ringed seal population. Article in Journal/Newspaper Arctic greenlandic Pusa hispida ringed seal Sea ice TiHo eLib (University of Veterinary Medicine Hannover) Environmental Research 244 117839 |
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Open Polar |
collection |
TiHo eLib (University of Veterinary Medicine Hannover) |
op_collection_id |
fttihohannover |
language |
English |
topic |
article ddc:570 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Metals Mercury Cytokines Immune response Biomarkers Endocrine system |
spellingShingle |
article ddc:570 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Metals Mercury Cytokines Immune response Biomarkers Endocrine system Boyi, Joy Ometere Sonne, Christian Dietz, Rune Rigét, Frank Siebert, Ursula Lehnert, Kristina Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
topic_facet |
article ddc:570 Hochschulbibliographie allgemein Verzeichnis wissenschaftlicher Veröffentlichungen 2023 Metals Mercury Cytokines Immune response Biomarkers Endocrine system |
description |
Marine top predators such as ringed seals biomagnify environmental contaminants; and with the increasing human activities in the Arctic, ringed seals are exposed to biologically significant concentrations of trace elements resulting in reproductive impairment, immunosuppression, and neurological damages. Little is known about the molecular effects of heavy metals on these vulnerable apex predators suffering from a rapidly changing Arctic with significant loss of sea-ice. In the present study, concentrations of cadmium (Cd), mercury (Hg) and selenium (Se) were measured in liver of sixteen Greenlandic ringed seals (nine adults and seven subadults) together with molecular biomarkers involved in bio-transformation, oxidative stress, endocrine disruption and immune activity in blood and blubber. The concentrations of trace elements increased in the following order: Hg > Se > Cd with levels of mercury and selenium being highest in adults. Aryl hydrocarbon receptor nuclear translocator (ARNT), peroxisome proliferator activated receptor alpha (PPARα, estrogen receptor alpha (ESR1), thyroid hormone receptor alpha (TRα) and interleukin - 2 (IL-2) mRNA transcript levels were highest in blubber, while heat shock protein 70 (HSP70) and interleukin - 10 (IL-10) were significantly higher in blood. There were no significant correlations between the concentrations of trace elements and mRNA transcript levels suggesting that stressors other than the trace elements investigated are responsible for the changes in gene expression levels. Since Hg seems to increase in Greenlandic ringed seals, there is a need to re-enforce health monitoring of this ringed seal population. |
format |
Article in Journal/Newspaper |
author |
Boyi, Joy Ometere Sonne, Christian Dietz, Rune Rigét, Frank Siebert, Ursula Lehnert, Kristina |
author_facet |
Boyi, Joy Ometere Sonne, Christian Dietz, Rune Rigét, Frank Siebert, Ursula Lehnert, Kristina |
author_sort |
Boyi, Joy Ometere |
title |
Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
title_short |
Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
title_full |
Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
title_fullStr |
Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
title_full_unstemmed |
Gene expression and trace elements in greenlandic ringed seals (Pusa hispida) |
title_sort |
gene expression and trace elements in greenlandic ringed seals (pusa hispida) |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.envres.2023.117839 https://elib.tiho-hannover.de/receive/tiho_mods_00010344 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002616/1-s2.0-S0013935123026439-main.pdf https://www.sciencedirect.com/science/article/pii/S0013935123026439?via%3Dihub |
genre |
Arctic greenlandic Pusa hispida ringed seal Sea ice |
genre_facet |
Arctic greenlandic Pusa hispida ringed seal Sea ice |
op_relation |
Environmental research -- Environ. Res. -- ER -- 1467489-0 -- 0013-9351 -- 1096-0953 -- https://www.sciencedirect.com/journal/environmental-research -- http://ezb.uni-regensburg.de/ezeit/detail.phtml?bibid=TIHO&colors=7&lang=de&jour_id=1579 https://doi.org/10.1016/j.envres.2023.117839 https://elib.tiho-hannover.de/receive/tiho_mods_00010344 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00002616/1-s2.0-S0013935123026439-main.pdf https://www.sciencedirect.com/science/article/pii/S0013935123026439?via%3Dihub |
op_rights |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.envres.2023.117839 |
container_title |
Environmental Research |
container_volume |
244 |
container_start_page |
117839 |
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1799474882733408256 |