Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species
The relevance of emerging infectious diseases continues to grow worldwide as human activities increasingly extend into formerly remote natural areas. This is particularly noticeable on the island of Madagascar. As closest relatives to humans on the island, lemurs are of particular relevance as a pot...
Published in: | American Journal of Primatology |
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2023
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Online Access: | https://doi.org/10.1002/ajp.23458 https://elib.tiho-hannover.de/receive/tiho_mods_00008029 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001972/American%20J%20Primatol%20-%202022%20-%20Kiene%20-%20Filarial%20infections%20in%20lemurs%20Evidence%20for%20a%20wide%20geographical%20distribution%20and%20low.pdf https://onlinelibrary.wiley.com/doi/10.1002/ajp.23458 |
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fttihohannover:oai:elib.tiho-hannover.de:tiho_mods_00008029 2024-06-23T07:56:25+00:00 Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species Kiene, Frederik Springer, Andrea Andriatsitohaina, Bertrand Ramsay, Malcolm S. Rakotondravony, Romule Strube, Christina Radespiel, Ute 2023 https://doi.org/10.1002/ajp.23458 https://elib.tiho-hannover.de/receive/tiho_mods_00008029 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001972/American%20J%20Primatol%20-%202022%20-%20Kiene%20-%20Filarial%20infections%20in%20lemurs%20Evidence%20for%20a%20wide%20geographical%20distribution%20and%20low.pdf https://onlinelibrary.wiley.com/doi/10.1002/ajp.23458 eng eng American journal of primatology -- Am. J. Primatol. -- 1495834-X -- 1098-2345 -- 0275-2565 -- https://onlinelibrary.wiley.com/journal/10982345 -- http://ezb.uni-regensburg.de/ezeit/?1495834 https://doi.org/10.1002/ajp.23458 https://elib.tiho-hannover.de/receive/tiho_mods_00008029 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001972/American%20J%20Primatol%20-%202022%20-%20Kiene%20-%20Filarial%20infections%20in%20lemurs%20Evidence%20for%20a%20wide%20geographical%20distribution%20and%20low.pdf https://onlinelibrary.wiley.com/doi/10.1002/ajp.23458 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess article Verzeichnis wissenschaftlicher Veröffentlichungen Hochschulbibliographie allgemein ddc:590 ddc:630 2023 article Text doc-type:article 2023 fttihohannover https://doi.org/10.1002/ajp.23458 2024-05-29T23:30:25Z The relevance of emerging infectious diseases continues to grow worldwide as human activities increasingly extend into formerly remote natural areas. This is particularly noticeable on the island of Madagascar. As closest relatives to humans on the island, lemurs are of particular relevance as a potential origin of zoonotic pathogen spillover. Knowledge of pathogens circulating in lemur populations is, however, very poor. Particularly little is known about lemur hemoparasites. To infer host range, ecological and geographic spread of the recently described hemoparasitic nematode Lemurfilaria lemuris in northwestern Madagascar, a total of 942 individuals of two mouse lemur species (Microcebus murinus [n = 207] and Microcebus ravelobensis [n = 433]) and two rodent species (the endemic Eliurus myoxinus [n = 118] and the invasive Rattus rattus [n = 184]) were captured in two fragmented forest landscapes (Ankarafantsika National Park and Mariarano Classified Forest) in northwestern Madagascar for blood sample examination. No protozoan hemoparasites were detected by microscopic blood smear screening. Microfilaria were present in 1.0% (2/207) of M. murinus and 2.1% (9/433) of M. ravelobensis blood samples but not in rodent samples. Internal transcribed spacer 1 (ITS-1) sequences were identical to an unnamed Onchocercidae species previously described to infect a larger lemur species, Propithecus verreauxi, about 650 km further south. In contrast to expectations, L. lemuris was not detected. The finding of a pathogen in a distantly related host species, at a considerable geographic distance from the location of its original detection, instead of a microfilaria species previously described for one of the studied host species in the same region, illustrates our low level of knowledge of lemur hemoparasites, their host ranges, distribution, modes of transmission, and their zoonotic potential. Our findings shall stimulate new research that will be of relevance for both conservation medicine and human epidemiology. Article in Journal/Newspaper Rattus rattus TiHo eLib (University of Veterinary Medicine Hannover) American Journal of Primatology 85 2 |
institution |
Open Polar |
collection |
TiHo eLib (University of Veterinary Medicine Hannover) |
op_collection_id |
fttihohannover |
language |
English |
topic |
article Verzeichnis wissenschaftlicher Veröffentlichungen Hochschulbibliographie allgemein ddc:590 ddc:630 2023 |
spellingShingle |
article Verzeichnis wissenschaftlicher Veröffentlichungen Hochschulbibliographie allgemein ddc:590 ddc:630 2023 Kiene, Frederik Springer, Andrea Andriatsitohaina, Bertrand Ramsay, Malcolm S. Rakotondravony, Romule Strube, Christina Radespiel, Ute Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
topic_facet |
article Verzeichnis wissenschaftlicher Veröffentlichungen Hochschulbibliographie allgemein ddc:590 ddc:630 2023 |
description |
The relevance of emerging infectious diseases continues to grow worldwide as human activities increasingly extend into formerly remote natural areas. This is particularly noticeable on the island of Madagascar. As closest relatives to humans on the island, lemurs are of particular relevance as a potential origin of zoonotic pathogen spillover. Knowledge of pathogens circulating in lemur populations is, however, very poor. Particularly little is known about lemur hemoparasites. To infer host range, ecological and geographic spread of the recently described hemoparasitic nematode Lemurfilaria lemuris in northwestern Madagascar, a total of 942 individuals of two mouse lemur species (Microcebus murinus [n = 207] and Microcebus ravelobensis [n = 433]) and two rodent species (the endemic Eliurus myoxinus [n = 118] and the invasive Rattus rattus [n = 184]) were captured in two fragmented forest landscapes (Ankarafantsika National Park and Mariarano Classified Forest) in northwestern Madagascar for blood sample examination. No protozoan hemoparasites were detected by microscopic blood smear screening. Microfilaria were present in 1.0% (2/207) of M. murinus and 2.1% (9/433) of M. ravelobensis blood samples but not in rodent samples. Internal transcribed spacer 1 (ITS-1) sequences were identical to an unnamed Onchocercidae species previously described to infect a larger lemur species, Propithecus verreauxi, about 650 km further south. In contrast to expectations, L. lemuris was not detected. The finding of a pathogen in a distantly related host species, at a considerable geographic distance from the location of its original detection, instead of a microfilaria species previously described for one of the studied host species in the same region, illustrates our low level of knowledge of lemur hemoparasites, their host ranges, distribution, modes of transmission, and their zoonotic potential. Our findings shall stimulate new research that will be of relevance for both conservation medicine and human epidemiology. |
format |
Article in Journal/Newspaper |
author |
Kiene, Frederik Springer, Andrea Andriatsitohaina, Bertrand Ramsay, Malcolm S. Rakotondravony, Romule Strube, Christina Radespiel, Ute |
author_facet |
Kiene, Frederik Springer, Andrea Andriatsitohaina, Bertrand Ramsay, Malcolm S. Rakotondravony, Romule Strube, Christina Radespiel, Ute |
author_sort |
Kiene, Frederik |
title |
Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
title_short |
Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
title_full |
Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
title_fullStr |
Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
title_full_unstemmed |
Filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
title_sort |
filarial infections in lemurs: evidence for a wide geographical distribution and low host specificity among lemur species |
publishDate |
2023 |
url |
https://doi.org/10.1002/ajp.23458 https://elib.tiho-hannover.de/receive/tiho_mods_00008029 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001972/American%20J%20Primatol%20-%202022%20-%20Kiene%20-%20Filarial%20infections%20in%20lemurs%20Evidence%20for%20a%20wide%20geographical%20distribution%20and%20low.pdf https://onlinelibrary.wiley.com/doi/10.1002/ajp.23458 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
American journal of primatology -- Am. J. Primatol. -- 1495834-X -- 1098-2345 -- 0275-2565 -- https://onlinelibrary.wiley.com/journal/10982345 -- http://ezb.uni-regensburg.de/ezeit/?1495834 https://doi.org/10.1002/ajp.23458 https://elib.tiho-hannover.de/receive/tiho_mods_00008029 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00001972/American%20J%20Primatol%20-%202022%20-%20Kiene%20-%20Filarial%20infections%20in%20lemurs%20Evidence%20for%20a%20wide%20geographical%20distribution%20and%20low.pdf https://onlinelibrary.wiley.com/doi/10.1002/ajp.23458 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1002/ajp.23458 |
container_title |
American Journal of Primatology |
container_volume |
85 |
container_issue |
2 |
_version_ |
1802649484586385408 |