Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina)
Detailed knowledge of age-related changes in the structure and mineralization of bones is important for interpreting osseous changes in wild mammals caused by exposure to environmental contaminants. This study analyzed mandibular size, microarchitecture and volumetric bone mineral density (vBMD) in...
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Online Access: | https://doi.org/10.1371/journal.pone.0224480 https://elib.tiho-hannover.de/receive/tiho_mods_00001998 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000510/journal.pone.0224480.pdf https://europepmc.org/articles/PMC6812799 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224480 |
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fttihohannover:oai:elib.tiho-hannover.de:tiho_mods_00001998 2024-04-28T08:22:54+00:00 Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) Kahle, Patricia Rolvien, Tim Kierdorf, Horst Roos, Anna Siebert, Ursula Kierdorf, Uwe 2019 https://doi.org/10.1371/journal.pone.0224480 https://elib.tiho-hannover.de/receive/tiho_mods_00001998 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000510/journal.pone.0224480.pdf https://europepmc.org/articles/PMC6812799 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224480 eng eng PLoS ONE -- http://www.bibliothek.uni-regensburg.de/ezeit/?2267670 -- http://www.plosone.org/home.action -- https://journals.plos.org/plosone/ -- https://www.ncbi.nlm.nih.gov/pmc/journals/440/ -- 1932-6203 -- 2267670-3 -- PLOS ONE https://doi.org/10.1371/journal.pone.0224480 https://elib.tiho-hannover.de/receive/tiho_mods_00001998 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000510/journal.pone.0224480.pdf https://europepmc.org/articles/PMC6812799 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224480 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess article Verzeichnis wissenschaftlicher Veröffentlichungen ddc:630 2019 Hochschulbibliographie allgemein Mandible Animals Phoca Organ Size Aging Bone Density article Text doc-type:article 2019 fttihohannover https://doi.org/10.1371/journal.pone.0224480 2024-04-11T16:57:37Z Detailed knowledge of age-related changes in the structure and mineralization of bones is important for interpreting osseous changes in wild mammals caused by exposure to environmental contaminants. This study analyzed mandibular size, microarchitecture and volumetric bone mineral density (vBMD) in harbor seals (n = 93, age range 0.5 months to 25 years) from the German North Sea. Bone microarchitecture and vBMD were assessed using high-resolution peripheral quantitative computed tomography (HR-pQCT). Significant differences were observed between the analyzed age classes (i) young juveniles (0.5-10 months), (ii) yearlings (12-23 months), and (iii) adults (12-25 years) for several of the variables, indicating an overall increase in cortical and trabecular area, cortical thickness and total and cortical vBMD with age. Furthermore, for juvenile animals (≤ 23 months), significant positive correlations with age were observed for mandible length and perimeter, cortical area, cortical thickness, trabecular separation, and total and cortical vBMD. The findings demonstrate a rapid increase in overall size, cortical dimensions and the degree of mineralization of the harbor seal mandible during the first two years after birth. Negative correlations with age existed for trabecular number and thickness as well as for trabecular bone volume fraction in the juveniles. The findings suggest a reduction in trabecular bone volume fraction with age, due to the bone trabeculae becoming thinner, less numerous and more widely spaced. Given the strong age dependence of most analyzed parameters, it is recommended to standardize samples with respect to age in future studies comparing microarchitecture and mineralization of harbor seal mandibles from different populations or different collection periods. Article in Journal/Newspaper harbor seal Phoca vitulina TiHo eLib (University of Veterinary Medicine Hannover) PLOS ONE 14 10 e0224480 |
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TiHo eLib (University of Veterinary Medicine Hannover) |
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language |
English |
topic |
article Verzeichnis wissenschaftlicher Veröffentlichungen ddc:630 2019 Hochschulbibliographie allgemein Mandible Animals Phoca Organ Size Aging Bone Density |
spellingShingle |
article Verzeichnis wissenschaftlicher Veröffentlichungen ddc:630 2019 Hochschulbibliographie allgemein Mandible Animals Phoca Organ Size Aging Bone Density Kahle, Patricia Rolvien, Tim Kierdorf, Horst Roos, Anna Siebert, Ursula Kierdorf, Uwe Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
topic_facet |
article Verzeichnis wissenschaftlicher Veröffentlichungen ddc:630 2019 Hochschulbibliographie allgemein Mandible Animals Phoca Organ Size Aging Bone Density |
description |
Detailed knowledge of age-related changes in the structure and mineralization of bones is important for interpreting osseous changes in wild mammals caused by exposure to environmental contaminants. This study analyzed mandibular size, microarchitecture and volumetric bone mineral density (vBMD) in harbor seals (n = 93, age range 0.5 months to 25 years) from the German North Sea. Bone microarchitecture and vBMD were assessed using high-resolution peripheral quantitative computed tomography (HR-pQCT). Significant differences were observed between the analyzed age classes (i) young juveniles (0.5-10 months), (ii) yearlings (12-23 months), and (iii) adults (12-25 years) for several of the variables, indicating an overall increase in cortical and trabecular area, cortical thickness and total and cortical vBMD with age. Furthermore, for juvenile animals (≤ 23 months), significant positive correlations with age were observed for mandible length and perimeter, cortical area, cortical thickness, trabecular separation, and total and cortical vBMD. The findings demonstrate a rapid increase in overall size, cortical dimensions and the degree of mineralization of the harbor seal mandible during the first two years after birth. Negative correlations with age existed for trabecular number and thickness as well as for trabecular bone volume fraction in the juveniles. The findings suggest a reduction in trabecular bone volume fraction with age, due to the bone trabeculae becoming thinner, less numerous and more widely spaced. Given the strong age dependence of most analyzed parameters, it is recommended to standardize samples with respect to age in future studies comparing microarchitecture and mineralization of harbor seal mandibles from different populations or different collection periods. |
format |
Article in Journal/Newspaper |
author |
Kahle, Patricia Rolvien, Tim Kierdorf, Horst Roos, Anna Siebert, Ursula Kierdorf, Uwe |
author_facet |
Kahle, Patricia Rolvien, Tim Kierdorf, Horst Roos, Anna Siebert, Ursula Kierdorf, Uwe |
author_sort |
Kahle, Patricia |
title |
Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
title_short |
Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
title_full |
Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
title_fullStr |
Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
title_full_unstemmed |
Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina) |
title_sort |
age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (phoca vitulina) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pone.0224480 https://elib.tiho-hannover.de/receive/tiho_mods_00001998 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000510/journal.pone.0224480.pdf https://europepmc.org/articles/PMC6812799 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224480 |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_relation |
PLoS ONE -- http://www.bibliothek.uni-regensburg.de/ezeit/?2267670 -- http://www.plosone.org/home.action -- https://journals.plos.org/plosone/ -- https://www.ncbi.nlm.nih.gov/pmc/journals/440/ -- 1932-6203 -- 2267670-3 -- PLOS ONE https://doi.org/10.1371/journal.pone.0224480 https://elib.tiho-hannover.de/receive/tiho_mods_00001998 https://elib.tiho-hannover.de/servlets/MCRFileNodeServlet/tiho_derivate_00000510/journal.pone.0224480.pdf https://europepmc.org/articles/PMC6812799 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224480 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0224480 |
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PLOS ONE |
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