Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression
© 2020, The Author(s). cc-by Growth hormone receptor (GHR) and prolactin receptor (PRLR) in jawed vertebrates were thought to arise after the divergence of gnathostomes from a basal vertebrate. In this study we have identified two genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marin...
Published in: | Scientific Reports |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/2346/92436 https://doi.org/10.1038/s41598-020-58344-5 |
id |
fttexastechuniv:oai:ttu-ir.tdl.org:2346/92436 |
---|---|
record_format |
openpolar |
spelling |
fttexastechuniv:oai:ttu-ir.tdl.org:2346/92436 2023-05-15T15:08:00+02:00 Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression Gong, Ningping (TTU) Ferreira-Martins, Diogo McCormick, Stephen D. Sheridan, Mark A. (TTU) 2020 application/pdf https://hdl.handle.net/2346/92436 https://doi.org/10.1038/s41598-020-58344-5 eng eng Gong, N., Ferreira-Martins, D., McCormick, S.D., & Sheridan, M.A. 2020. Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-58344-5 https://doi.org/10.1038/s41598-020-58344-5 https://hdl.handle.net/2346/92436 Article 2020 fttexastechuniv https://doi.org/10.1038/s41598-020-58344-5 2023-04-08T22:06:54Z © 2020, The Author(s). cc-by Growth hormone receptor (GHR) and prolactin receptor (PRLR) in jawed vertebrates were thought to arise after the divergence of gnathostomes from a basal vertebrate. In this study we have identified two genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marinus) and Arctic lamprey (Lethenteron camtschaticum), extant members of one of the oldest vertebrate groups, agnathans. Phylogenetic analysis revealed that lamprey GHR and PRLR cluster at the base of gnathostome GHR and PRLR clades, respectively. This indicates that distinct GHR and PRLR arose prior to the emergence of the lamprey branch of agnathans. In the sea lamprey, GHR and PRLR displayed a differential but overlapping pattern of expression; GHR had high expression in liver and heart tissues, whereas PRLR was expressed highly in the brain and moderately in osmoregulatory tissues. Branchial PRLR mRNA levels were significantly elevated by stage 5 of metamorphosis and remained elevated through stage 7, whereas levels of GHR mRNA were only elevated in the final stage (7). Branchial expression of GHR increased following seawater (SW) exposure of juveniles, but expression of PRLR was not significantly altered. The results indicate that GHR and PRLR may both participate in metamorphosis and that GHR may mediate SW acclimation. Article in Journal/Newspaper Arctic Texas Tech University: TTU DSpace Repository Arctic Scientific Reports 10 1 |
institution |
Open Polar |
collection |
Texas Tech University: TTU DSpace Repository |
op_collection_id |
fttexastechuniv |
language |
English |
description |
© 2020, The Author(s). cc-by Growth hormone receptor (GHR) and prolactin receptor (PRLR) in jawed vertebrates were thought to arise after the divergence of gnathostomes from a basal vertebrate. In this study we have identified two genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marinus) and Arctic lamprey (Lethenteron camtschaticum), extant members of one of the oldest vertebrate groups, agnathans. Phylogenetic analysis revealed that lamprey GHR and PRLR cluster at the base of gnathostome GHR and PRLR clades, respectively. This indicates that distinct GHR and PRLR arose prior to the emergence of the lamprey branch of agnathans. In the sea lamprey, GHR and PRLR displayed a differential but overlapping pattern of expression; GHR had high expression in liver and heart tissues, whereas PRLR was expressed highly in the brain and moderately in osmoregulatory tissues. Branchial PRLR mRNA levels were significantly elevated by stage 5 of metamorphosis and remained elevated through stage 7, whereas levels of GHR mRNA were only elevated in the final stage (7). Branchial expression of GHR increased following seawater (SW) exposure of juveniles, but expression of PRLR was not significantly altered. The results indicate that GHR and PRLR may both participate in metamorphosis and that GHR may mediate SW acclimation. |
format |
Article in Journal/Newspaper |
author |
Gong, Ningping (TTU) Ferreira-Martins, Diogo McCormick, Stephen D. Sheridan, Mark A. (TTU) |
spellingShingle |
Gong, Ningping (TTU) Ferreira-Martins, Diogo McCormick, Stephen D. Sheridan, Mark A. (TTU) Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
author_facet |
Gong, Ningping (TTU) Ferreira-Martins, Diogo McCormick, Stephen D. Sheridan, Mark A. (TTU) |
author_sort |
Gong, Ningping (TTU) |
title |
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
title_short |
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
title_full |
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
title_fullStr |
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
title_full_unstemmed |
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
title_sort |
divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression |
publishDate |
2020 |
url |
https://hdl.handle.net/2346/92436 https://doi.org/10.1038/s41598-020-58344-5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
Gong, N., Ferreira-Martins, D., McCormick, S.D., & Sheridan, M.A. 2020. Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-58344-5 https://doi.org/10.1038/s41598-020-58344-5 https://hdl.handle.net/2346/92436 |
op_doi |
https://doi.org/10.1038/s41598-020-58344-5 |
container_title |
Scientific Reports |
container_volume |
10 |
container_issue |
1 |
_version_ |
1766339427034988544 |