Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine
Substructure due to familial-associated divisions exists in all large populations. Geographical heterogeneity in US ethnic minorities is a function of historical, social, political, and economic factors overlaying regional geographical biodiversity. Using geospatial, historical, demographic, genetic...
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fttexasmc:oai:digitalcommons.library.tmc.edu:jfs-1344 2023-12-24T10:23:10+01:00 Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine Jackson, Hasan Jackson, Fatimah L.C. 2017-05-01T07:00:00Z application/pdf https://digitalcommons.library.tmc.edu/jfs/vol17/iss1/12 https://doi.org/10.58464/2168-670X.1344 https://digitalcommons.library.tmc.edu/context/jfs/article/1344/viewcontent/auto_convert.pdf https://digitalcommons.library.tmc.edu/context/jfs/article/1344/filename/0/type/additional/viewcontent/Copyedits_MS_1344_REVISED.docx unknown DigitalCommons@TMC https://digitalcommons.library.tmc.edu/jfs/vol17/iss1/12 doi:10.58464/2168-670X.1344 https://digitalcommons.library.tmc.edu/context/jfs/article/1344/viewcontent/auto_convert.pdf https://digitalcommons.library.tmc.edu/context/jfs/article/1344/filename/0/type/additional/viewcontent/Copyedits_MS_1344_REVISED.docx Journal of Family Strengths Precision medicine ethnogenetic layering microethnic isolates text 2017 fttexasmc https://doi.org/10.58464/2168-670X.1344 2023-11-26T17:38:51Z Substructure due to familial-associated divisions exists in all large populations. Geographical heterogeneity in US ethnic minorities is a function of historical, social, political, and economic factors overlaying regional geographical biodiversity. Using geospatial, historical, demographic, genetic, and epidemiological databases, we identify 40 US microethnic isolates across the US, the “minorities within ethnic minorities” and locate their geospatial distributions within the US. Key components of the environment relevant to health disparities are identified and elaborated in terms of their impact on genomics. US ethnic minority microethnic isolates often have distinct genetic and social histories from the US ethnic majority that put these isolates at a disadvantage in the quest for access to relevant, precision medicine because of the magnitude of imbedded (North Atlantic Euro-American) bias in the existing databases. However, these microethnic isolates are also at a disadvantage when simply aggregated with their nearest ethnic minority macroethnic group (e.g., generic African American). The use of geospatial and ethnographic analyses has the potential to accelerate the accurate identification of heretofore disadvantaged subgroups of ethnic minority groups, bringing them into the mainstream of genomic diversity studies and healthcare access Text North Atlantic Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center Journal of Family Strengths 17 1 |
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Open Polar |
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Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center |
op_collection_id |
fttexasmc |
language |
unknown |
topic |
Precision medicine ethnogenetic layering microethnic isolates |
spellingShingle |
Precision medicine ethnogenetic layering microethnic isolates Jackson, Hasan Jackson, Fatimah L.C. Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
topic_facet |
Precision medicine ethnogenetic layering microethnic isolates |
description |
Substructure due to familial-associated divisions exists in all large populations. Geographical heterogeneity in US ethnic minorities is a function of historical, social, political, and economic factors overlaying regional geographical biodiversity. Using geospatial, historical, demographic, genetic, and epidemiological databases, we identify 40 US microethnic isolates across the US, the “minorities within ethnic minorities” and locate their geospatial distributions within the US. Key components of the environment relevant to health disparities are identified and elaborated in terms of their impact on genomics. US ethnic minority microethnic isolates often have distinct genetic and social histories from the US ethnic majority that put these isolates at a disadvantage in the quest for access to relevant, precision medicine because of the magnitude of imbedded (North Atlantic Euro-American) bias in the existing databases. However, these microethnic isolates are also at a disadvantage when simply aggregated with their nearest ethnic minority macroethnic group (e.g., generic African American). The use of geospatial and ethnographic analyses has the potential to accelerate the accurate identification of heretofore disadvantaged subgroups of ethnic minority groups, bringing them into the mainstream of genomic diversity studies and healthcare access |
format |
Text |
author |
Jackson, Hasan Jackson, Fatimah L.C. |
author_facet |
Jackson, Hasan Jackson, Fatimah L.C. |
author_sort |
Jackson, Hasan |
title |
Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
title_short |
Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
title_full |
Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
title_fullStr |
Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
title_full_unstemmed |
Geospatial distribution and population substructure of subgroups of US ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
title_sort |
geospatial distribution and population substructure of subgroups of us ethnic minorities: implications for perpetuation of health disparities and paucity of precision medicine |
publisher |
DigitalCommons@TMC |
publishDate |
2017 |
url |
https://digitalcommons.library.tmc.edu/jfs/vol17/iss1/12 https://doi.org/10.58464/2168-670X.1344 https://digitalcommons.library.tmc.edu/context/jfs/article/1344/viewcontent/auto_convert.pdf https://digitalcommons.library.tmc.edu/context/jfs/article/1344/filename/0/type/additional/viewcontent/Copyedits_MS_1344_REVISED.docx |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_source |
Journal of Family Strengths |
op_relation |
https://digitalcommons.library.tmc.edu/jfs/vol17/iss1/12 doi:10.58464/2168-670X.1344 https://digitalcommons.library.tmc.edu/context/jfs/article/1344/viewcontent/auto_convert.pdf https://digitalcommons.library.tmc.edu/context/jfs/article/1344/filename/0/type/additional/viewcontent/Copyedits_MS_1344_REVISED.docx |
op_doi |
https://doi.org/10.58464/2168-670X.1344 |
container_title |
Journal of Family Strengths |
container_volume |
17 |
container_issue |
1 |
_version_ |
1786196970490036224 |