PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS
The aim of the work. To study the venotropic and anticoagulant activity of the dry extract of Sakhalin willowshoots (DESWS). Materials and Methods. The anticoagulant activity was determined in an «in vitro» experiment by the Burker method. To further study the anticoagulant activity of DESWS, we pro...
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Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
2023
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Online Access: | https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055 https://doi.org/10.11603/2312-0967.2023.2.14055 |
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ftternopilstmuni:oai:ojs.tdmu.edu.ua:article/14055 2023-10-09T21:55:41+02:00 PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS ФАРМАКОЛОГІЧНЕ ВИВЧЕННЯ ВЕНОТРОПНОЇ АКТИВНОСТІ СУХОГО ЕКСТРАКТУ ПАГОНІВ ВЕРБИ САХАЛІНСЬКОЇ Maloshtan, L. M. Artemova, K. O. 2023-06-30 application/pdf https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055 https://doi.org/10.11603/2312-0967.2023.2.14055 ukr ukr Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055/12986 https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055 doi:10.11603/2312-0967.2023.2.14055 Авторське право (c) 2023 Фармацевтичний часопис https://creativecommons.org/licenses/by-nc/4.0 Pharmaceutical Review / Farmacevtičnij časopis; No. 2 (2023); 46-53 Фармацевтичний часопис; № 2 (2023); 46-53 2414-9926 2312-0967 10.11603/2312-0967.2023.2 DESWS venotropic activity anticoagulant activity rats escuvit chronic venous insufficiency сухий екстракт пагонів верби сахалінської венотропна активність антикоагулянтна активність щури ескувіт хронічна венозна недостатність info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftternopilstmuni https://doi.org/10.11603/2312-0967.2023.2.1405510.11603/2312-0967.2023.2 2023-09-18T23:42:08Z The aim of the work. To study the venotropic and anticoagulant activity of the dry extract of Sakhalin willowshoots (DESWS). Materials and Methods. The anticoagulant activity was determined in an «in vitro» experiment by the Burker method. To further study the anticoagulant activity of DESWS, we proceeded to an «in vivo» experiment, where we used doses of 30 mg/kg, 60 mg/kg, and 90 mg/kg. For 4 days, once a day the animals were administered intragastrically with the studied DESWS in the form of an aqueous solution at the rate of 0.5 ml per 100 g of body weight. On the 4th day, blood was taken from the tail of the rats after the injection of the test samples in 60 min and the blood clotting time was determined. The next stage of our research was to study the effect of DESWS on the course of edema in venous stasis of the tail in rats. The object of the study was a dry extract of Sakhalin willow shoots, conventionally designated DESWS. Results and Discussion. DESWS was used in three test doses in the form of aqueous solutions. The study was carried out on white non-breeding rats weighing 200–250 g, 5 rats per group: group 1 – intact control, which was administered distilled water; group 2 – rats receiving the test extract at a dose of 20 mg/kg, group 3 – rats receiving DESWS at a dose of 30 mg/kg, group 4 – rats receiving DESWS at a dose of 40 mg/kg. According to the data obtained, DESWS at a dose of 20 mg/kg significantly increased the blood clotting time by 1.15 times compared to the control. The anticoagulant activity of DESWS at a dose of 30 mg/kg and 40 mg/kg was almost at the same level, as evidenced by a significant slowing of blood clotting time compared to the control by 1.47 and 1.5 times, respectively. The comparison drug Escuvit increased the blood clotting time by 1.26 times compared to the control. Conclusions. DESWS has shown anticoagulant activity in «in vitro» and «in vivo» studies. The conditionally therapeutic dose of DESWS-30 mg/kg was established in the study of anticoagulant activity in ... Article in Journal/Newspaper Sakhalin Scientific Journals of Ternopil State Medical University |
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Scientific Journals of Ternopil State Medical University |
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ftternopilstmuni |
language |
Ukrainian |
topic |
DESWS venotropic activity anticoagulant activity rats escuvit chronic venous insufficiency сухий екстракт пагонів верби сахалінської венотропна активність антикоагулянтна активність щури ескувіт хронічна венозна недостатність |
spellingShingle |
DESWS venotropic activity anticoagulant activity rats escuvit chronic venous insufficiency сухий екстракт пагонів верби сахалінської венотропна активність антикоагулянтна активність щури ескувіт хронічна венозна недостатність Maloshtan, L. M. Artemova, K. O. PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
topic_facet |
DESWS venotropic activity anticoagulant activity rats escuvit chronic venous insufficiency сухий екстракт пагонів верби сахалінської венотропна активність антикоагулянтна активність щури ескувіт хронічна венозна недостатність |
description |
The aim of the work. To study the venotropic and anticoagulant activity of the dry extract of Sakhalin willowshoots (DESWS). Materials and Methods. The anticoagulant activity was determined in an «in vitro» experiment by the Burker method. To further study the anticoagulant activity of DESWS, we proceeded to an «in vivo» experiment, where we used doses of 30 mg/kg, 60 mg/kg, and 90 mg/kg. For 4 days, once a day the animals were administered intragastrically with the studied DESWS in the form of an aqueous solution at the rate of 0.5 ml per 100 g of body weight. On the 4th day, blood was taken from the tail of the rats after the injection of the test samples in 60 min and the blood clotting time was determined. The next stage of our research was to study the effect of DESWS on the course of edema in venous stasis of the tail in rats. The object of the study was a dry extract of Sakhalin willow shoots, conventionally designated DESWS. Results and Discussion. DESWS was used in three test doses in the form of aqueous solutions. The study was carried out on white non-breeding rats weighing 200–250 g, 5 rats per group: group 1 – intact control, which was administered distilled water; group 2 – rats receiving the test extract at a dose of 20 mg/kg, group 3 – rats receiving DESWS at a dose of 30 mg/kg, group 4 – rats receiving DESWS at a dose of 40 mg/kg. According to the data obtained, DESWS at a dose of 20 mg/kg significantly increased the blood clotting time by 1.15 times compared to the control. The anticoagulant activity of DESWS at a dose of 30 mg/kg and 40 mg/kg was almost at the same level, as evidenced by a significant slowing of blood clotting time compared to the control by 1.47 and 1.5 times, respectively. The comparison drug Escuvit increased the blood clotting time by 1.26 times compared to the control. Conclusions. DESWS has shown anticoagulant activity in «in vitro» and «in vivo» studies. The conditionally therapeutic dose of DESWS-30 mg/kg was established in the study of anticoagulant activity in ... |
format |
Article in Journal/Newspaper |
author |
Maloshtan, L. M. Artemova, K. O. |
author_facet |
Maloshtan, L. M. Artemova, K. O. |
author_sort |
Maloshtan, L. M. |
title |
PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
title_short |
PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
title_full |
PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
title_fullStr |
PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
title_full_unstemmed |
PHARMACOLOGICAL STUDY OF VENOTROPIC ACTIVITY OF DRY EXTRACT OF SAKHALIN WILLOW SHOOTS |
title_sort |
pharmacological study of venotropic activity of dry extract of sakhalin willow shoots |
publisher |
Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України |
publishDate |
2023 |
url |
https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055 https://doi.org/10.11603/2312-0967.2023.2.14055 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
Pharmaceutical Review / Farmacevtičnij časopis; No. 2 (2023); 46-53 Фармацевтичний часопис; № 2 (2023); 46-53 2414-9926 2312-0967 10.11603/2312-0967.2023.2 |
op_relation |
https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055/12986 https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/14055 doi:10.11603/2312-0967.2023.2.14055 |
op_rights |
Авторське право (c) 2023 Фармацевтичний часопис https://creativecommons.org/licenses/by-nc/4.0 |
op_doi |
https://doi.org/10.11603/2312-0967.2023.2.1405510.11603/2312-0967.2023.2 |
_version_ |
1779319676831006720 |