Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men

• Published in: Scientific Reports
• Main Authors: Brovold, Henrik, Lund, Trine, Svistounov, Dmitri, Solbu, Marit Dahl, Jenssen, Trond Geir, Ytrehus, Kirsti, Zykova, Svetlana
• Format: Report
• Language: English
• Published: Springer Nature 2019
• Subjects: Andreassen; Arctic; Norway; Steinnes; Tromsø; Arctic University of Norway; UiT The Arctic University of Norway
• Online Access: http://hdl.handle.net/11250/2634513; https://doi.org/10.1038/s41598-019-46935-w

Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus cre...