Genetic predisposition to Parkinson's disease:CYP2D6 and HFE in the Faroe Islands
OBJECTIVE: To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased. METHODS: Blood samples were collected from 79 PD patients and 154 c...
| Published in: | Pharmacogenetics and Genomics |
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| Main Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://portal.findresearcher.sdu.dk/da/publications/fffe6f80-fc45-11dc-86ef-000ea68e967b https://doi.org/10.1097/FPC.0b013e3282f5106e https://findresearcher.sdu.dk/ws/files/200413868/grandjean_genetic_2008.pdf http://www.jpharmacogenetics.com/pt/re/pharmgen/abstract.01213011-200803000-00005.htm;jsessionid=HsQhQwC84jVbKzK0BRypKXy7PGMhLHjKpKpqWsYml2JWs82NytyC!923867264!181195629!8091!-1 |
| Summary: | OBJECTIVE: To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased. METHODS: Blood samples were collected from 79 PD patients and 154 controls in the Faroe Islands. Genotyping for the 'CYP2D6*3, *4, *6 and *9' alleles and for the C282Y and H63D mutations were performed by real-time polymerase chain reaction before Taqman assessment. RESULTS: The frequency of CYP2D6 poor metabolizers among the patients was not higher compared with the frequency found in the control group (χ test, P=0.86). The odds ratio was 0.92 (95% confidence interval: 0.44-1.90). Neither was a difference in HFE genotype or allele frequencies found between the patients and the controls, and the C282Y and H63D mutation carrier frequencies did not reveal any difference (χ test, P=0.50 and 0.60, respectively). CONCLUSION: This study does not support an association between PD and mutations of the CYP2D6 and HFE genes, although a weak association cannot be excluded. The high frequency of PD in the Faroes is most likely the result of interactions between multiple genetic and environmental factors, still to be identified. |
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