Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold
Background: Cold-induced peripheral neuropathy has been described in individuals exposed to severe cold resulting in pain, hypersensitivity to cold, hyperhidrosis, numbness, and skin changes. Nerve conduction studies and thermal detection thresholds are abnormal in symptomatic patients, and intraepi...
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/f9681749-c2d7-441e-b9ba-c6c806606dea https://doi.org/10.1002/brb3.917 https://findresearcher.sdu.dk/ws/files/137592101/Asymptomatic_loss_of_intraepidermal_nerve_fibers_with_preserved_thermal_detection_thresholds_after_repeated_exposure_to_severe_cold.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/f9681749-c2d7-441e-b9ba-c6c806606dea 2024-04-21T08:03:33+00:00 Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold Krøigård, Thomas Wirenfeldt, Martin Svendsen, Toke K. Sindrup, Søren H. 2018-03 application/pdf https://portal.findresearcher.sdu.dk/da/publications/f9681749-c2d7-441e-b9ba-c6c806606dea https://doi.org/10.1002/brb3.917 https://findresearcher.sdu.dk/ws/files/137592101/Asymptomatic_loss_of_intraepidermal_nerve_fibers_with_preserved_thermal_detection_thresholds_after_repeated_exposure_to_severe_cold.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/f9681749-c2d7-441e-b9ba-c6c806606dea info:eu-repo/semantics/openAccess Krøigård , T , Wirenfeldt , M , Svendsen , T K & Sindrup , S H 2018 , ' Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold ' , Brain and Behavior , vol. 8 , no. 3 , e009147 . https://doi.org/10.1002/brb3.917 Adult Cold Temperature/adverse effects Greenland Humans Male Nerve Fibers/physiology Neurologic Examination/methods Norway Pain Threshold/physiology Peripheral Nervous System Diseases/diagnosis Skin/innervation article 2018 ftsydanskunivpub https://doi.org/10.1002/brb3.917 2024-03-27T15:37:21Z Background: Cold-induced peripheral neuropathy has been described in individuals exposed to severe cold resulting in pain, hypersensitivity to cold, hyperhidrosis, numbness, and skin changes. Nerve conduction studies and thermal detection thresholds are abnormal in symptomatic patients, and intraepidermal nerve fiber density (IENFD) in skin biopsies is reduced. Case presentation: A 41-year-old male was included as a healthy subject in a study of the spontaneous variability of quantitative sensory testing (QST), nerve conduction studies (NCS), and IENFD. Unexpectedly, IENFD was significantly reduced, whereas the rest of the examination was normal except for reduced vibration detection threshold. The results were confirmed at follow-up examination. The subject had been repeatedly exposed to severe cold resulting in short lasting numbness and paresthesia while living in the eastern part of Greenland and the northern part of Norway. Conclusion: Loss of intraepidermal nerve fibers caused by exposure to severe cold may be asymptomatic, and their function assessed by thermal detection thresholds may be preserved. This case illustrates that QST and IENFD are complementary tests and that subclinical cold-induced peripheral neuropathy may be prevalent in subjects living in or near polar regions which could have implications for the recruitment of healthy subjects. Article in Journal/Newspaper Greenland University of Southern Denmark Research Portal Brain and Behavior 8 3 e009147 |
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Open Polar |
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University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Adult Cold Temperature/adverse effects Greenland Humans Male Nerve Fibers/physiology Neurologic Examination/methods Norway Pain Threshold/physiology Peripheral Nervous System Diseases/diagnosis Skin/innervation |
spellingShingle |
Adult Cold Temperature/adverse effects Greenland Humans Male Nerve Fibers/physiology Neurologic Examination/methods Norway Pain Threshold/physiology Peripheral Nervous System Diseases/diagnosis Skin/innervation Krøigård, Thomas Wirenfeldt, Martin Svendsen, Toke K. Sindrup, Søren H. Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
topic_facet |
Adult Cold Temperature/adverse effects Greenland Humans Male Nerve Fibers/physiology Neurologic Examination/methods Norway Pain Threshold/physiology Peripheral Nervous System Diseases/diagnosis Skin/innervation |
description |
Background: Cold-induced peripheral neuropathy has been described in individuals exposed to severe cold resulting in pain, hypersensitivity to cold, hyperhidrosis, numbness, and skin changes. Nerve conduction studies and thermal detection thresholds are abnormal in symptomatic patients, and intraepidermal nerve fiber density (IENFD) in skin biopsies is reduced. Case presentation: A 41-year-old male was included as a healthy subject in a study of the spontaneous variability of quantitative sensory testing (QST), nerve conduction studies (NCS), and IENFD. Unexpectedly, IENFD was significantly reduced, whereas the rest of the examination was normal except for reduced vibration detection threshold. The results were confirmed at follow-up examination. The subject had been repeatedly exposed to severe cold resulting in short lasting numbness and paresthesia while living in the eastern part of Greenland and the northern part of Norway. Conclusion: Loss of intraepidermal nerve fibers caused by exposure to severe cold may be asymptomatic, and their function assessed by thermal detection thresholds may be preserved. This case illustrates that QST and IENFD are complementary tests and that subclinical cold-induced peripheral neuropathy may be prevalent in subjects living in or near polar regions which could have implications for the recruitment of healthy subjects. |
format |
Article in Journal/Newspaper |
author |
Krøigård, Thomas Wirenfeldt, Martin Svendsen, Toke K. Sindrup, Søren H. |
author_facet |
Krøigård, Thomas Wirenfeldt, Martin Svendsen, Toke K. Sindrup, Søren H. |
author_sort |
Krøigård, Thomas |
title |
Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
title_short |
Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
title_full |
Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
title_fullStr |
Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
title_full_unstemmed |
Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
title_sort |
asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold |
publishDate |
2018 |
url |
https://portal.findresearcher.sdu.dk/da/publications/f9681749-c2d7-441e-b9ba-c6c806606dea https://doi.org/10.1002/brb3.917 https://findresearcher.sdu.dk/ws/files/137592101/Asymptomatic_loss_of_intraepidermal_nerve_fibers_with_preserved_thermal_detection_thresholds_after_repeated_exposure_to_severe_cold.pdf |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Krøigård , T , Wirenfeldt , M , Svendsen , T K & Sindrup , S H 2018 , ' Asymptomatic loss of intraepidermal nerve fibers with preserved thermal detection thresholds after repeated exposure to severe cold ' , Brain and Behavior , vol. 8 , no. 3 , e009147 . https://doi.org/10.1002/brb3.917 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/f9681749-c2d7-441e-b9ba-c6c806606dea |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1002/brb3.917 |
container_title |
Brain and Behavior |
container_volume |
8 |
container_issue |
3 |
container_start_page |
e009147 |
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1796943358370775040 |