Population studies of the human V kappa A18 gene polymorphism in Caucasians, blacks and Eskimos. New functional alleles and evidence for evolutionary selection of a more restricted antibody repertoire

• Main Authors: Juul, L, Hougs, L, Andersen, V, Garred, P, Ryder, L, Svejgaard, A, Høgh, B, Lamm, L, Graugaard, B, Barington, T
• Format: Article in Journal/Newspaper
• Language: English
• Published: 1997
• Subjects: African Continental Ancestry Group; Alleles; Amino Acid Sequence; Base Sequence; Cloning; Molecular; DNA; Complementary; Denmark; European Continental Ancestry Group; Gene Expression; Humans; Immunoglobulin Variable Region; Immunoglobulin kappa-Chains; Inuits; Molecular Sequence Data; Mozambique; Polymerase Chain Reaction; Polymorphism; Genetic; Restriction Fragment Length; RNA; Messenger; Atkinson; Greenland; eskimo*; inuits
• Online Access: https://portal.findresearcher.sdu.dk/da/publications/f42920e0-a290-11de-9743-000ea68e967b

Udgivelsesdato: 1997-Jun Immunoglobulin gene polymorphisms are interesting because they reflect differences in the available antibody repertoire which may affect the susceptibility to specific infections. Until recently, the human V kappa gene, A18, was known as a nonfunctional gene only. In this st...