Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration
BACKGROUND: The reputed low prevalence of cardiovascular disease among the Inuit has recently been challenged. Studies have shown total cholesterol among the Inuit to differ little from that of western populations and the association between cholesterol and atherosclerosis to be inconsistent. METHOD...
Published in: | Atherosclerosis |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2004
|
Subjects: | |
Online Access: | https://portal.findresearcher.sdu.dk/da/publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 https://doi.org/10.1016/j.atherosclerosis.2004.02.010 |
id |
ftsydanskunivpub:oai:sdu.dk:publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 |
---|---|
record_format |
openpolar |
spelling |
ftsydanskunivpub:oai:sdu.dk:publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 2024-06-23T07:53:13+00:00 Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration 2004-06 https://portal.findresearcher.sdu.dk/da/publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 https://doi.org/10.1016/j.atherosclerosis.2004.02.010 eng eng https://portal.findresearcher.sdu.dk/da/publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 info:eu-repo/semantics/closedAccess The Greenland Population Study Group 2004 , ' Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration ' , Atherosclerosis , vol. 174 , no. 2 , pp. 391-398 . https://doi.org/10.1016/j.atherosclerosis.2004.02.010 Adolescent Adult Age Factors Analysis of Variance Cross-Sectional Studies Denmark/epidemiology Emigration and Immigration Female Genetic Predisposition to Disease Greenland/epidemiology Humans Hyperlipidemias/ethnology Inuits/genetics Lipids/blood Male Middle Aged Population Surveillance Probability Risk Factors Surveys and Questionnaires Triglycerides/blood article 2004 ftsydanskunivpub https://doi.org/10.1016/j.atherosclerosis.2004.02.010 2024-06-04T14:47:44Z BACKGROUND: The reputed low prevalence of cardiovascular disease among the Inuit has recently been challenged. Studies have shown total cholesterol among the Inuit to differ little from that of western populations and the association between cholesterol and atherosclerosis to be inconsistent. METHODS: We studied serum lipids in a population survey among 2114 Inuit living in Denmark or in West Greenland. Blood tests were supplemented by structured interviews, anthropometry and measurements of blood pressure. FINDINGS: Compared with the general population of Denmark, total cholesterol was higher among Inuit women, while HDL-cholesterol was higher among Inuit men. Triglyceride was lower among Inuit of both sexes. Cholesterol and triglyceride varied according to westernisation, diet, alcohol consumption and smoking. In a multivariate analysis, serum lipids also differed significantly between pure and genetically mixed Inuit: HDL-cholesterol was higher among the genetically pure Inuit, while among men triglyceride was lower and among women total and LDL-cholesterol were higher. INTERPRETATION: Among the Inuit, serum lipids are significantly associated with westernisation and genetic heritage. The effect of westernisation is to some extent due to dietary changes. From a cardiovascular health point of view, westernisation within Greenland is associated with unfavourable lipid changes while migration to Denmark is associated with favourable lipid changes. Article in Journal/Newspaper Greenland inuit inuits University of Southern Denmark Research Portal Greenland Atherosclerosis 174 2 391 398 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Adolescent Adult Age Factors Analysis of Variance Cross-Sectional Studies Denmark/epidemiology Emigration and Immigration Female Genetic Predisposition to Disease Greenland/epidemiology Humans Hyperlipidemias/ethnology Inuits/genetics Lipids/blood Male Middle Aged Population Surveillance Probability Risk Factors Surveys and Questionnaires Triglycerides/blood |
spellingShingle |
Adolescent Adult Age Factors Analysis of Variance Cross-Sectional Studies Denmark/epidemiology Emigration and Immigration Female Genetic Predisposition to Disease Greenland/epidemiology Humans Hyperlipidemias/ethnology Inuits/genetics Lipids/blood Male Middle Aged Population Surveillance Probability Risk Factors Surveys and Questionnaires Triglycerides/blood Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
topic_facet |
Adolescent Adult Age Factors Analysis of Variance Cross-Sectional Studies Denmark/epidemiology Emigration and Immigration Female Genetic Predisposition to Disease Greenland/epidemiology Humans Hyperlipidemias/ethnology Inuits/genetics Lipids/blood Male Middle Aged Population Surveillance Probability Risk Factors Surveys and Questionnaires Triglycerides/blood |
description |
BACKGROUND: The reputed low prevalence of cardiovascular disease among the Inuit has recently been challenged. Studies have shown total cholesterol among the Inuit to differ little from that of western populations and the association between cholesterol and atherosclerosis to be inconsistent. METHODS: We studied serum lipids in a population survey among 2114 Inuit living in Denmark or in West Greenland. Blood tests were supplemented by structured interviews, anthropometry and measurements of blood pressure. FINDINGS: Compared with the general population of Denmark, total cholesterol was higher among Inuit women, while HDL-cholesterol was higher among Inuit men. Triglyceride was lower among Inuit of both sexes. Cholesterol and triglyceride varied according to westernisation, diet, alcohol consumption and smoking. In a multivariate analysis, serum lipids also differed significantly between pure and genetically mixed Inuit: HDL-cholesterol was higher among the genetically pure Inuit, while among men triglyceride was lower and among women total and LDL-cholesterol were higher. INTERPRETATION: Among the Inuit, serum lipids are significantly associated with westernisation and genetic heritage. The effect of westernisation is to some extent due to dietary changes. From a cardiovascular health point of view, westernisation within Greenland is associated with unfavourable lipid changes while migration to Denmark is associated with favourable lipid changes. |
format |
Article in Journal/Newspaper |
title |
Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
title_short |
Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
title_full |
Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
title_fullStr |
Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
title_full_unstemmed |
Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration |
title_sort |
serum lipids of greenland inuit in relation to inuit genetic heritage, westernisation and migration |
publishDate |
2004 |
url |
https://portal.findresearcher.sdu.dk/da/publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 https://doi.org/10.1016/j.atherosclerosis.2004.02.010 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
The Greenland Population Study Group 2004 , ' Serum lipids of Greenland Inuit in relation to Inuit genetic heritage, westernisation and migration ' , Atherosclerosis , vol. 174 , no. 2 , pp. 391-398 . https://doi.org/10.1016/j.atherosclerosis.2004.02.010 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/f2b63d11-48fd-40c8-b241-d8f3b650a222 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.atherosclerosis.2004.02.010 |
container_title |
Atherosclerosis |
container_volume |
174 |
container_issue |
2 |
container_start_page |
391 |
op_container_end_page |
398 |
_version_ |
1802644787819446272 |