Management of early onset neonatal sepsis differs in the north and south of Scandinavia
Aim: This study compared the management and outcomes of early-onset neonatal sepsis (EONS) in two tertiary neonatal units in Denmark and Norway. Methods: We retrospectively studied all infants diagnosed with EONS between April 2010 and March 2013 and managed at Odense University Hospital, Denmark, a...
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 https://doi.org/10.1111/apa.13698 |
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ftsydanskunivpub:oai:sdu.dk:publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 2024-09-15T18:24:50+00:00 Management of early onset neonatal sepsis differs in the north and south of Scandinavia Drageset, Martin Fjalstad, Jon Widding Mortensen, Sven Klingenberg, Claus 2017-03 https://portal.findresearcher.sdu.dk/da/publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 https://doi.org/10.1111/apa.13698 eng eng https://portal.findresearcher.sdu.dk/da/publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 info:eu-repo/semantics/closedAccess Drageset , M , Fjalstad , J W , Mortensen , S & Klingenberg , C 2017 , ' Management of early onset neonatal sepsis differs in the north and south of Scandinavia ' , Acta Paediatrica , vol. 106 , no. 3 , pp. 375–381 . https://doi.org/10.1111/apa.13698 Antibiotics C-reactive protein Early-onset neonatal sepsis Lumbar puncture Staphylococcus aureus Denmark/epidemiology Humans Norway/epidemiology Retrospective Studies Anti-Bacterial Agents/therapeutic use Infant Newborn Neonatal Sepsis/drug therapy article 2017 ftsydanskunivpub https://doi.org/10.1111/apa.13698 2024-08-05T23:48:16Z Aim: This study compared the management and outcomes of early-onset neonatal sepsis (EONS) in two tertiary neonatal units in Denmark and Norway. Methods: We retrospectively studied all infants diagnosed with EONS between April 2010 and March 2013 and managed at Odense University Hospital, Denmark, and the University Hospital of North Norway, Norway. Clinical and laboratory data were collected from patient records. Results: We identified 137 EONS cases in Denmark and 101 in Norway. There were 35 culture-confirmed EONS cases: 16% of the Danish cases and 13% of the Norwegian cases. Staphylococcus aureus was the most frequently detected pathogen in 11 cases (31%), followed by Group B streptococci in nine (26%) and Escherichia coli in six (17%). In 85% of the 238 cases, the empiric therapy comprised gentamicin and a beta-lactam, namely ampicillin in Denmark and benzylpenicillin in Norway. Patients with positive blood cultures had higher C-reactive protein levels than patients with negative blood cultures and higher sepsis-attributable mortality. Lumbar punctures were performed more frequently in Denmark. Conclusion: There were marginal differences in the management of EONS between units in Denmark and Norway, mainly in their choice of antibiotics and the use of lumbar punctures. Staphylococcus aureus was the most common pathogen. Article in Journal/Newspaper North Norway University of Southern Denmark Research Portal Acta Paediatrica 106 3 375 381 |
institution |
Open Polar |
collection |
University of Southern Denmark Research Portal |
op_collection_id |
ftsydanskunivpub |
language |
English |
topic |
Antibiotics C-reactive protein Early-onset neonatal sepsis Lumbar puncture Staphylococcus aureus Denmark/epidemiology Humans Norway/epidemiology Retrospective Studies Anti-Bacterial Agents/therapeutic use Infant Newborn Neonatal Sepsis/drug therapy |
spellingShingle |
Antibiotics C-reactive protein Early-onset neonatal sepsis Lumbar puncture Staphylococcus aureus Denmark/epidemiology Humans Norway/epidemiology Retrospective Studies Anti-Bacterial Agents/therapeutic use Infant Newborn Neonatal Sepsis/drug therapy Drageset, Martin Fjalstad, Jon Widding Mortensen, Sven Klingenberg, Claus Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
topic_facet |
Antibiotics C-reactive protein Early-onset neonatal sepsis Lumbar puncture Staphylococcus aureus Denmark/epidemiology Humans Norway/epidemiology Retrospective Studies Anti-Bacterial Agents/therapeutic use Infant Newborn Neonatal Sepsis/drug therapy |
description |
Aim: This study compared the management and outcomes of early-onset neonatal sepsis (EONS) in two tertiary neonatal units in Denmark and Norway. Methods: We retrospectively studied all infants diagnosed with EONS between April 2010 and March 2013 and managed at Odense University Hospital, Denmark, and the University Hospital of North Norway, Norway. Clinical and laboratory data were collected from patient records. Results: We identified 137 EONS cases in Denmark and 101 in Norway. There were 35 culture-confirmed EONS cases: 16% of the Danish cases and 13% of the Norwegian cases. Staphylococcus aureus was the most frequently detected pathogen in 11 cases (31%), followed by Group B streptococci in nine (26%) and Escherichia coli in six (17%). In 85% of the 238 cases, the empiric therapy comprised gentamicin and a beta-lactam, namely ampicillin in Denmark and benzylpenicillin in Norway. Patients with positive blood cultures had higher C-reactive protein levels than patients with negative blood cultures and higher sepsis-attributable mortality. Lumbar punctures were performed more frequently in Denmark. Conclusion: There were marginal differences in the management of EONS between units in Denmark and Norway, mainly in their choice of antibiotics and the use of lumbar punctures. Staphylococcus aureus was the most common pathogen. |
format |
Article in Journal/Newspaper |
author |
Drageset, Martin Fjalstad, Jon Widding Mortensen, Sven Klingenberg, Claus |
author_facet |
Drageset, Martin Fjalstad, Jon Widding Mortensen, Sven Klingenberg, Claus |
author_sort |
Drageset, Martin |
title |
Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
title_short |
Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
title_full |
Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
title_fullStr |
Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
title_full_unstemmed |
Management of early onset neonatal sepsis differs in the north and south of Scandinavia |
title_sort |
management of early onset neonatal sepsis differs in the north and south of scandinavia |
publishDate |
2017 |
url |
https://portal.findresearcher.sdu.dk/da/publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 https://doi.org/10.1111/apa.13698 |
genre |
North Norway |
genre_facet |
North Norway |
op_source |
Drageset , M , Fjalstad , J W , Mortensen , S & Klingenberg , C 2017 , ' Management of early onset neonatal sepsis differs in the north and south of Scandinavia ' , Acta Paediatrica , vol. 106 , no. 3 , pp. 375–381 . https://doi.org/10.1111/apa.13698 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/f0347e03-32df-4fb5-8746-2cd04e36ec62 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1111/apa.13698 |
container_title |
Acta Paediatrica |
container_volume |
106 |
container_issue |
3 |
container_start_page |
375 |
op_container_end_page |
381 |
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1810465247426772992 |