Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark
BACKGROUND: Uncertainty in the risk of reproductive complications (pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility) following chlamydia infection and repeat infection hampers the design of evidence-based chlamydia control programmes. We estimate the association between d...
Published in: | The Lancet Infectious Diseases |
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Online Access: | https://portal.findresearcher.sdu.dk/da/publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 https://doi.org/10.1016/S1473-3099(16)30092-5 https://findresearcher.sdu.dk/ws/files/123253051/Risk_of_reproductive_complications_following_chlamydia_testing.pdf |
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ftsydanskunivpub:oai:sdu.dk:publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 2024-09-15T18:10:08+00:00 Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark Davies, Bethan Turner, Katy M E Frølund, Maria Ward, Helen May, Margaret T Rasmussen, Steen Benfield, Thomas Westh, Henrik Søgaard, Per 2016 application/pdf https://portal.findresearcher.sdu.dk/da/publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 https://doi.org/10.1016/S1473-3099(16)30092-5 https://findresearcher.sdu.dk/ws/files/123253051/Risk_of_reproductive_complications_following_chlamydia_testing.pdf eng eng https://portal.findresearcher.sdu.dk/da/publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 info:eu-repo/semantics/openAccess Davies , B , Turner , K M E , Frølund , M , Ward , H , May , M T , Rasmussen , S , Benfield , T , Westh , H , Danish Chlamydia Study Group & Søgaard , P 2016 , ' Risk of reproductive complications following chlamydia testing : a population-based retrospective cohort study in Denmark ' , The Lancet Infectious Diseases , vol. 16 , no. 9 , pp. 1057–1064 . https://doi.org/10.1016/S1473-3099(16)30092-5 article 2016 ftsydanskunivpub https://doi.org/10.1016/S1473-3099(16)30092-5 2024-07-22T23:48:46Z BACKGROUND: Uncertainty in the risk of reproductive complications (pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility) following chlamydia infection and repeat infection hampers the design of evidence-based chlamydia control programmes. We estimate the association between diagnosed chlamydia and episodes of hospital health care (inpatient, outpatient, and emergency department) for a reproductive complication. METHODS: We constructed and analysed a retrospective population-based cohort of women aged 15-44 years from administrative records in Denmark (1995-2012). We used a subset of the national Danish Chlamydia Study. The master dataset contains all residents of Denmark (including Greenland) who had a positive chlamydia test recorded by a public health microbiology laboratory from Jan 1, 1992, to Nov 2, 2011. Individuals were randomly matched (by age and sex) to four individuals drawn from the population register (Danish Civil Registration System) who did not have a positive chlamydia test during this interval. The outcomes in the study were hospital episodes of health-care (inpatient, outpatient, and emergency department) with a diagnosis of pelvic inflammatory disease, ectopic pregnancy, or tubal factor infertility. FINDINGS: The 516 720 women (103 344 positive, 182 879 negative, 230 497 never-tested) had a mean follow-up of 7·96 years. Compared with women with only negative tests, the risk of each complication was 30% higher in women with one or more positive tests (pelvic inflammatory disease, adjusted hazard ratio [AHR] 1·50 [95% CI 1·43-1·57]; ectopic pregnancy, AHR 1·31 [1·25-1·38]; tubal factor infertility, AHR 1·37 [1·24-1·52]) and 60% lower in women who were never-tested (pelvic inflammatory disease, AHR 0·33 [0·31-0·35]; ectopic pregnancy, AHR 0·42 [0·39-0·44]; tubal factor infertility AHR 0·29 [0·25-0·33]). A positive test had a minor absolute impact on health as the difference in the lifetime incidence of complications was small between women who tested positive and those ... Article in Journal/Newspaper Greenland University of Southern Denmark Research Portal The Lancet Infectious Diseases 16 9 1057 1064 |
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Open Polar |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
language |
English |
description |
BACKGROUND: Uncertainty in the risk of reproductive complications (pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility) following chlamydia infection and repeat infection hampers the design of evidence-based chlamydia control programmes. We estimate the association between diagnosed chlamydia and episodes of hospital health care (inpatient, outpatient, and emergency department) for a reproductive complication. METHODS: We constructed and analysed a retrospective population-based cohort of women aged 15-44 years from administrative records in Denmark (1995-2012). We used a subset of the national Danish Chlamydia Study. The master dataset contains all residents of Denmark (including Greenland) who had a positive chlamydia test recorded by a public health microbiology laboratory from Jan 1, 1992, to Nov 2, 2011. Individuals were randomly matched (by age and sex) to four individuals drawn from the population register (Danish Civil Registration System) who did not have a positive chlamydia test during this interval. The outcomes in the study were hospital episodes of health-care (inpatient, outpatient, and emergency department) with a diagnosis of pelvic inflammatory disease, ectopic pregnancy, or tubal factor infertility. FINDINGS: The 516 720 women (103 344 positive, 182 879 negative, 230 497 never-tested) had a mean follow-up of 7·96 years. Compared with women with only negative tests, the risk of each complication was 30% higher in women with one or more positive tests (pelvic inflammatory disease, adjusted hazard ratio [AHR] 1·50 [95% CI 1·43-1·57]; ectopic pregnancy, AHR 1·31 [1·25-1·38]; tubal factor infertility, AHR 1·37 [1·24-1·52]) and 60% lower in women who were never-tested (pelvic inflammatory disease, AHR 0·33 [0·31-0·35]; ectopic pregnancy, AHR 0·42 [0·39-0·44]; tubal factor infertility AHR 0·29 [0·25-0·33]). A positive test had a minor absolute impact on health as the difference in the lifetime incidence of complications was small between women who tested positive and those ... |
format |
Article in Journal/Newspaper |
author |
Davies, Bethan Turner, Katy M E Frølund, Maria Ward, Helen May, Margaret T Rasmussen, Steen Benfield, Thomas Westh, Henrik Søgaard, Per |
spellingShingle |
Davies, Bethan Turner, Katy M E Frølund, Maria Ward, Helen May, Margaret T Rasmussen, Steen Benfield, Thomas Westh, Henrik Søgaard, Per Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
author_facet |
Davies, Bethan Turner, Katy M E Frølund, Maria Ward, Helen May, Margaret T Rasmussen, Steen Benfield, Thomas Westh, Henrik Søgaard, Per |
author_sort |
Davies, Bethan |
title |
Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
title_short |
Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
title_full |
Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
title_fullStr |
Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
title_full_unstemmed |
Risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in Denmark |
title_sort |
risk of reproductive complications following chlamydia testing:a population-based retrospective cohort study in denmark |
publishDate |
2016 |
url |
https://portal.findresearcher.sdu.dk/da/publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 https://doi.org/10.1016/S1473-3099(16)30092-5 https://findresearcher.sdu.dk/ws/files/123253051/Risk_of_reproductive_complications_following_chlamydia_testing.pdf |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Davies , B , Turner , K M E , Frølund , M , Ward , H , May , M T , Rasmussen , S , Benfield , T , Westh , H , Danish Chlamydia Study Group & Søgaard , P 2016 , ' Risk of reproductive complications following chlamydia testing : a population-based retrospective cohort study in Denmark ' , The Lancet Infectious Diseases , vol. 16 , no. 9 , pp. 1057–1064 . https://doi.org/10.1016/S1473-3099(16)30092-5 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/c78283a5-190a-4fcf-a10d-0a444da5bda6 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/S1473-3099(16)30092-5 |
container_title |
The Lancet Infectious Diseases |
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16 |
container_issue |
9 |
container_start_page |
1057 |
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1064 |
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1810447738922336256 |