Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury
Few studies have examined the effects of mixed metal exposures in humans. We have evaluated the effect of prenatal lead exposure in a Faroese birth cohort in the presence of similar molar-level exposure to methylmercury. A cohort of 1022 singleton births was assembled in the Faroe Islands during 198...
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ftsydanskunivpub:oai:sdu.dk:publications/be25ae3d-4b54-42d8-8171-f9b89eec89d1 2024-09-15T18:05:42+00:00 Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury Yorifuji, Takashi Debes, Frodi Weihe, Pal Grandjean, Philippe 2011 https://portal.findresearcher.sdu.dk/da/publications/be25ae3d-4b54-42d8-8171-f9b89eec89d1 https://doi.org/10.1016/j.ntt.2010.09.004 eng eng https://portal.findresearcher.sdu.dk/da/publications/be25ae3d-4b54-42d8-8171-f9b89eec89d1 info:eu-repo/semantics/restrictedAccess Yorifuji , T , Debes , F , Weihe , P & Grandjean , P 2011 , ' Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury ' , Neurotoxicology and Teratology , vol. 33 , pp. 205-11 . https://doi.org/10.1016/j.ntt.2010.09.004 article 2011 ftsydanskunivpub https://doi.org/10.1016/j.ntt.2010.09.004 2024-07-08T23:46:59Z Few studies have examined the effects of mixed metal exposures in humans. We have evaluated the effect of prenatal lead exposure in a Faroese birth cohort in the presence of similar molar-level exposure to methylmercury. A cohort of 1022 singleton births was assembled in the Faroe Islands during 1986-1987 from whom lead was measured in cord-blood. A total of 896 cohort subjects participated in a clinical examination at age 7 and 808 subjects in a second examination at age 14. We evaluated the association between cord-blood lead concentrations and cognitive deficits (attention/working memory, language, visuospatial, and memory) using multiple regression models. Overall, the lead concentration showed no clear pattern of association. However, in subjects with a low methylmercury exposure, after inclusion of statistical interaction terms, lead-associated adverse effects on cognitive functions were observed. In particular, higher cord-blood lead was associated with a lower digit span forward score on the Wechsler Intelligence Scale for Children-Revised (WISC-R) [beta=-1.70, 95% confidence interval (CI): -3.12 to -0.28] at age 7 and a lower digit span backward score on the WISC-R (beta=-2.73, 95%CI: -4.32 to -1.14) at age 14. Some interaction terms between lead and methylmercury suggested that the combined effect of the exposures was less than additive. The present study indicates that adverse effects of exposure may be overlooked if the effects of a co-pollutant are ignored. The present study supports the existence of adverse effects on cognitive functions at prenatal lead exposures corresponding to an average cord-blood concentration of 16μg/L. Article in Journal/Newspaper Faroe Islands University of Southern Denmark Research Portal Neurotoxicology and Teratology 33 2 205 211 |
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University of Southern Denmark Research Portal |
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ftsydanskunivpub |
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English |
description |
Few studies have examined the effects of mixed metal exposures in humans. We have evaluated the effect of prenatal lead exposure in a Faroese birth cohort in the presence of similar molar-level exposure to methylmercury. A cohort of 1022 singleton births was assembled in the Faroe Islands during 1986-1987 from whom lead was measured in cord-blood. A total of 896 cohort subjects participated in a clinical examination at age 7 and 808 subjects in a second examination at age 14. We evaluated the association between cord-blood lead concentrations and cognitive deficits (attention/working memory, language, visuospatial, and memory) using multiple regression models. Overall, the lead concentration showed no clear pattern of association. However, in subjects with a low methylmercury exposure, after inclusion of statistical interaction terms, lead-associated adverse effects on cognitive functions were observed. In particular, higher cord-blood lead was associated with a lower digit span forward score on the Wechsler Intelligence Scale for Children-Revised (WISC-R) [beta=-1.70, 95% confidence interval (CI): -3.12 to -0.28] at age 7 and a lower digit span backward score on the WISC-R (beta=-2.73, 95%CI: -4.32 to -1.14) at age 14. Some interaction terms between lead and methylmercury suggested that the combined effect of the exposures was less than additive. The present study indicates that adverse effects of exposure may be overlooked if the effects of a co-pollutant are ignored. The present study supports the existence of adverse effects on cognitive functions at prenatal lead exposures corresponding to an average cord-blood concentration of 16μg/L. |
format |
Article in Journal/Newspaper |
author |
Yorifuji, Takashi Debes, Frodi Weihe, Pal Grandjean, Philippe |
spellingShingle |
Yorifuji, Takashi Debes, Frodi Weihe, Pal Grandjean, Philippe Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
author_facet |
Yorifuji, Takashi Debes, Frodi Weihe, Pal Grandjean, Philippe |
author_sort |
Yorifuji, Takashi |
title |
Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
title_short |
Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
title_full |
Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
title_fullStr |
Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
title_full_unstemmed |
Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
title_sort |
prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury |
publishDate |
2011 |
url |
https://portal.findresearcher.sdu.dk/da/publications/be25ae3d-4b54-42d8-8171-f9b89eec89d1 https://doi.org/10.1016/j.ntt.2010.09.004 |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Yorifuji , T , Debes , F , Weihe , P & Grandjean , P 2011 , ' Prenatal exposure to lead and cognitive deficit in 7- and 14-year-old children in the presence of concomitant exposure to similar molar concentration of methylmercury ' , Neurotoxicology and Teratology , vol. 33 , pp. 205-11 . https://doi.org/10.1016/j.ntt.2010.09.004 |
op_relation |
https://portal.findresearcher.sdu.dk/da/publications/be25ae3d-4b54-42d8-8171-f9b89eec89d1 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.ntt.2010.09.004 |
container_title |
Neurotoxicology and Teratology |
container_volume |
33 |
container_issue |
2 |
container_start_page |
205 |
op_container_end_page |
211 |
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1810443223505567744 |